CAS: 37440-01-0; Ac-D-2-Nal-Oh

上下游产品

CAS号37447-33-9 acetylamino-[2]... | CAS号939-26-4 2-(溴甲基)萘 | CAS号37439-99-9 (S)-2-乙酰氨基-3-(萘...

(Z)-2-Acetamido-3-(Naphthalen-2-yl)Acrylic Acid置于bf4*(Ps,Ps)-1,1'-Bis(Diphenylphosphino)-2,2'-Di-3-Pentylferrocene 氢气体系中,用 乙醇 用作溶剂,化学反应生成(R)-N-乙酰基-Beta-萘基丙氨酸
参考文献:新型圆柱形手性和空气稳定的二茂铁基二膦的不对称合成及其在铑催化的不对称加氢中的应用
标题:新型圆柱形手性和空气稳定的二茂铁基二膦的不对称合成及其在铑催化的不对称加氢中的应用
摘要:合成了一种新颖的圆柱形手性空气稳定的二茂铁基二膦配体,并将其铑配合物用于不对称氢化.在各种脱氢氨基酸衍生物的氢化中已经实现了高反应性和选择性.
Doi:10.1016/s0040-4039(98)01089-2

专利信息

专利号:US-12098218-B2
优先权日:2015-12-17
标题 :Process for the manufacture of degarelix and its intermediates
发明人：RICCI ANTONIO; ZANON JACOPO; CABRI WALTER; GURYANOV IVAN; ORLANDIN ANDREA; BIONDI BARBARA; FORMAGGIO FERNANDO; VISENTINI DARIO
权利人:FRESENIUS KABI IPSUM S R L
摘要:The present invention provides a manufacturing process for preparing a peptide, preferably a decapeptide, such as degarelix, by incorporating p-nitro-phenylalanin in the amino acid sequence preferably during stepwise solid phase synthesis, and converting these into the required amino acids Aph(Hor) and/or D-Aph(Cbm), preferably while attached to a solid phase. The invention further provides intermediates useful in the manufacturing process.

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