CAS: 37517-81-0; Methyl 3-Chloro-3-Oxopropanoate

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36239-09-5 108-59-8 6001-87-2

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Malonic acid monomethyl ester monomethyl monopotassium malonate methyl hydrogen succinateMethyl 2-(N-phenylamin°Carbonyl)acetate N-{3-[(2-Methoxycarbonyl-acetylamino)-methyl]-benzyl}-malonamic acid methyl ester N-{4-[(2-Methoxycarbonyl-acetylamino)-methyl]-benzyl}-malonamic acid methyl ester N-(Methoxycarbonylacetyl)glycin-ethylester

丁二酸单甲酯置于氯化亚砜体系中,用 苯 作为反应溶剂,化学反应 1.5H,反应生成 丙二酸甲酯酰氯
参考文献:用于促进癌细胞凋亡的化合物,其医药组合物 及其用途
标题:用于促进癌细胞凋亡的化合物,其医药组合物 及其用途
摘要:本发明公开了用于促进癌细胞凋亡的化合物,其医药组合物及其用途.具体地,本发明提供一种式(I)化合物或其盐,其中,M为2至7的整数,以及r独立选自由氢及c1‑c20烷基所组成组的至少一者.该化合物用以促进癌细胞的细胞凋亡,以抑制癌细胞的生长.本发明进一步提供一种医药组合物,该医药组合物包含式(I)的化合物或其盐以及医药上可接受的载剂.本发明再进一步提供一种包含式(I)的化合物或其盐的用途,用于制造治疗癌症的药物.

专利信息

专利号:US-12240835-B2
优先权日:2018-09-18
标题:Substituted benzamides as intermediates in the synthesis of inhibitors of tyrosine kinase enzymatic activity
发明人：ROMERO F ANTHONY; KIRSCHBERG THORSTEN A; HALCOMB RANDALL; XU YINGZI
权利人:TERNS PHARMACEUTICALS INC
摘要:Provided herein are compounds, preferably compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, compositions thereof, and methods of their preparation, and methods of inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, and methods for treating diseases wherein modulation of BCR-ABL1 activity prevents, inhibits, or ameliorates the pathology and/or symptomology of the disease. Intermediates such as compounds of Formula (S23), which are useful in the synthesis of compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, are also provided.

专利号:US-2006047167-A1
优先权日:2004-09-02
标题 :Method of synthesis of water soluble fullerene polyacids using a malonate reactant
发明人：HIRSCH ANDREAS; BEUERLE FLORIAN; CHRONAKIS NIKOS
权利人:HIRSCH ANDREAS; BEUERLE FLORIAN; CHRONAKIS NIKOS
摘要:In one embodiment, the present invention is directed to a method for synthesizing compounds of the formula n n nwhere C m is a fullerene having m carbon atoms, the method comprising the steps of forming a linear malonate compound of the formula n n nwhere each Z is the same or different and is a straight-chain or branched-chain aliphatic radical having from 1-30 carbon atoms which may be unsubstituted or monosubstituted or polysubstituted by identical or different substitutents, in which radicals up to every third —CH 2 — unit can be replaced by O or NR″, n is an integer from 2 to 10, and the unfilled valences of the first and nth malonate groups are filled with bonds to hydrogen, a hydrocarbon group or substituted hydrocarbon group having 1-20 carbon atoms, or a chain containing unsubstituted or substituted aryl or other cyclic groups; or (ii) a branched malonate compound of the formula n n nwhere Z′ is an aliphatic radical having from 1-30 carbon atoms which may be unsubstituted or monosubstituted or polysubstituted by identical or different substitutents, in which radicals up to every third —CH 2 — unit can be replaced by O or NR″; and n is an integer from 2 to 10; n n reacting said malonate compound with C m to form an adduct of the formula n neach Z is bonded to both one carboxylate group of a first malonate moiety and one carboxylate group of a second malonate moiety and the unfilled valences of the first and nth malonate groups are filled with bonds to hydrogen, a hydrocarbon group or substituted hydrocarbon group having 1-20 carbon atoms, or a chain containing unsubstituted or substituted aryl or other cyclic groups; and hydrolyzing said adduct to form the compound.

专利号:WO-2006028776-A1
优先权日:2004-09-02
标题:Method of synthesis of water soluble fullerene polyacids using a malonate reactant
发明人：HIRSCH ANDREAS
权利人:SIXTY INC C; HIRSCH ANDREAS
摘要:A method for synthesizing compounds of the formula (I) where Cm is a fullerene having m carbon atoms and each R is independently -H or -Râ€? COOH where R is alkyl having 1-20 carbon atoms, substituted alkyl having 1-20 carbon atoms, alkenyl having 1-20 carbon atoms, substituted alkenyl having 1-20 carbon atoms, or a chain containing unsubstituted or substituted aryl or other cyclic groups, the method comprising the steps of forming a linear or branched malonate compound and hydrolyzing said adduct to form the compound.

专利号:US-9402842-B2
优先权日:2012-04-13
标题:Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (Tdp1)—topoisomerase I (Top1) inhibitors
发明人：CUSHMAN MARK S; NGUYEN TRUNG X; CONDA-SHERIDAN MARTIN M; POMMIER YVES GEORGE
权利人:PURDUE RESEARCH FOUNDATION
摘要:The invention described herein pertains to the synthesis and use of certain N-substituted indenoisoquinoline compounds which inhibit the activity Tyrosyl-DNA Phosphodiesterase I (Tdp1) or Topoisomerase I (Top1) or both, or otherwise demonstrate anticancer activity. Also disclosed are novel N-substituted indenoisoquinoline compounds and pharmaceutical compositions comprising the novel N-substituted indenoisoquinoline compounds.

专利号:US-2023192718-A1
优先权日:2018-03-30
标 题 :Bicyclic enone carboxylates as modulators of transporters and uses thereof
发明人：SANDANAYAKA VINCENT
权利人:NIROGY THERAPEUTICS INC
摘要:The invention generally relates to the field of monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate enone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.

专利号:US-11027027-B2
优先权日:2015-01-30
标 题:Pyridazinoindole compounds and methods for PET imaging
发明人：MANNING H CHARLES; CHEUNG YIU-YIN; BUCK JASON R; LI JUN
权利人:UNIV VANDERBILT
摘要:Embodiments of the invention include a novel synthesis of the translocator protein (TSPO) ligands, and methods of imaging a molecular events. Also disclosed are compounds for treatment of diseases, including cancer.