专利号:US-6033882-A 优先权日:1994-07-07 标题:Chiral synthesis of 2-hydroxy carboxylic acids with a dehydrogenase 发明人:HOLBROOK JOSEPH JOHN; WILLIS CHRISTINE LOUISE; JOHNSEN KEYJI; HATELEY MARTIN JOHN 权利人:GENZYME CORP 摘要:PCT No. PCT/EP95/02692 Sec. 371 Date May 29, 1997 Sec. 102(e) Date May 29, 1997 PCT Filed Jul. 7, 1995 PCT Pub. No. WO96/01892 PCT Pub. Date Jan. 25, 1996Inter alia, an enzyme, a 2-hydroxy carboxylic acid dehydrogenase, characterised in that it is obtainable from Lactobacillus delbrueckii ssp. Bulgaricus and in that it catalyses the production of (R)-hydroxy derivatives of 2-keto acids, which are unsubstituted in the 3-position, but which may be substituted in the 4-position or beyond is disclosed.
专利号:WO-9601892-A1 优先权日:1994-07-07 标 题 :Chiral synthesis of 2-hydroxy carboxylic acids with a dehydrogenase
专利号:EP-0767832-A1 优先权日:1994-07-07 标题:Chiral synthesis of 2-hydroxy carboxylic acids with a dehydrogenase
专利号:US-9249154-B2 优先权日:2008-01-08 标题:Compounds and therapeutic use thereof for protein kinase inhibition 发明人:WU ZHANGGUI 权利人:WU ZHANGGUI 摘要:Novel compound having the following formula: n nAlso disclosed are a pharmaceutical compositions comprising the same, methods for treating cancer using the same, and methods for the synthesis of the same. The novel compounds of the present invention are found to inhibit protein kinases, especially Checkpoint kinase Chk1/Chk2.
专利号:US-4970215-A 优先权日:1988-05-31 标 题:Substituted 4-(quinolin-2-yl-methoxy)phenyl-acetic acid derivatives and anti-allergic use thereof 发明人:MOHRS KLAUS; RADDATZ SIEGFRIED; PERZBORN ELISABETH; FRUCHTMANN ROMANIS; KOHLSDORFER CHRISTIAN; MUELLER-PEDDINGHAUS REINER; THEISEN PIA 权利人:BAYER AG 摘要:Leucotriene synthesis inhibiting substituted 4-(quinolin-2-yl-methoxy)phenyl-acetic acid derivatives of the formula (I) R1-represents a group of the formula wherein Y-represents a group of the formula Z-represents norbornyl, or represents a group of the formula and A and B are identical or different and denote hydrogen, lower alkyl or halogen, and salts thereof.
专利号:RU-2146254-C1 优先权日:1996-06-29 标 题 :Derivatives of piperazine and method of their synthesis