CAS: 39620-04-7; 2-Amino-3-Chloropyridine

相似化合物

873456-96-3 54231-32-2 4214-74-8

上下游产品

2,3-dichloro-pyridine phenyl carbamate 2-aminopyridine -2,2'-diamine3,3'-bipyridine-2,2'-diamine pyridine8-chloro-2-(4'-tolyl)imidazo1,2-apyridine 2-iodo-3-pyridyl chloride 5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one

2,3-二氯吡啶置于ammonium Hydroxide体系中,化学反应 48.0H,以70%的收率获得3-氯-2-氨基吡啶
参考文献: Azetidines And Cyclobutanes As Histamine H3 Receptor Antagonists[fr] Azétidines Et Cyclobutanes Comme Antagonistes Des Récepteurs H3 De L'Histamine
标题: Azetidines And Cyclobutanes As Histamine H3 Receptor Antagonists[fr] Azétidines Et Cyclobutanes Comme Antagonistes Des Récepteurs H3 De L'Histamine
摘要:本发明涉及具有式(I)的化合物,其中r,R0,R1,M,N和x1至x4如描述和权利要求中所引述的含义.所述化合物作为组胺h3受体拮抗剂是有用的.本发明还涉及药物组合物,以及此类化合物的制备以及作为药品的生产和使用.

专利信息

专利号:US-5077408-A
优先权日:1989-09-20
标 题 :Process for the synthesis of oxazolopyridine compounds
发明人：GUILLAUMET GERALD; FLOUZAT CHRISTINE
权利人:SCIENCE ORGANISATION
摘要:Process for the synthesis of compounds of formula (I): ##STR1## their pyridinium salts and N-oxides, in which formula: the nitrogen of the pyridine ring is situated in the α-, β-, γ- or δ-position with respect to the ring junction; n R 1 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, substituted or unsubstituted amino, phenyl or cyano group; n 0≦m≦2; n R 2 represents a lower alkyl or cycloalkyl group, a 5- or 6-membered heterocycle containing 1 or 2 hetero atoms, substituted or otherwise, or an aryl group ##STR2## such that: R 3 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, phenyl, substituted or unsubstituted sulfonyl, cyano, thioalkyl, substituted or unsubstituted amino, substituted or unsubstituted sulfinyl, mercapto, hydroxyl or ester group, n 0≦n≦5 n employing trimethylsilyl polyphosphate (PPSE) as a cyclization agent and enabling the compounds of formula (I) to be obtained in virtually quantitative yields. The compounds of formula I have anti-inflammatory, analgesic, and antipyretic activity.

专利号:US-2023010886-A1
优先权日:2019-09-23
标 题 :Shp2 inhibitors and uses thereof
发明人：XIE YINONG; BABISS LEE E
权利人:SUZHOU PUHE BIOPHARMA CO LTD
摘要:Compounds of Formula 1 as inhibitors of protein tyrosine phosphatase SHP2 are disclosed. The pharmaceutical compositions comprising compounds of Formula 1, methods of synthesis of these compounds, methods of treatment for diseases associated with the aberrant activity of SHP2 such as cancer using these compounds or compositions containing these compounds are also disclosed.

专利号:US-2024239799-A1
优先权日:2021-04-02
标 题:(s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo [1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
发明人：DI FABIO ROMANO; MONTALBETTI CHRISTIAN; PETROCCHI ALESSIA; GRILLO ALESSANDRO; RANDAZZO PIETRO; ROSSETTI ILARIA; CIAMMAICHELLA ALINA
权利人:C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING; IRBM S P A
摘要:The present invention relates to compounds of formula (I). The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio) pyrazin-2-yl)-41H,6′H-spiro[piperidine-4,5′-pyrrolo[1,2-b]pyrazol]-41-amine derivatives and similar compounds. The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof. The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.

专利号:US-7405310-B2
优先权日:2001-03-05
标 题:Non-nucleoside reverse transcriptase inhibitors
发明人：LINDSTROM STEFAN; SAHLBERG CHRISTER; WALLBERG HANS; KALYANOV GENAIDY; ODEN LOURDES SALVADOR; NAESLUND LOTTA
权利人:MEDIVIR AB
摘要:This invention relates to non-nucleoside reverse transcriptase inhibitors active against HIV-1 and having an improved resistance and pharmacokinetic profile. The invention further relates to novel intermediates in the synthesis of such compounds and the use of the compounds in antiviral methods and compositions.

专利号:US-10561655-B2
优先权日:2018-03-21
标 题 :SHP2 inhibitors and uses thereof
发明人：XIE YINONG; BABISS LEE E
权利人:SYNBLIA THERAPEUTICS INC
摘要:Compounds of Formula 1 as inhibitors of protein tyrosine phosphatase SHP2 are disclosed. The pharmaceutical compositions comprising compounds of Formula 1, methods of synthesis of these compounds, methods of treatment for diseases associated with the aberrant activity of SHP2 such as cancer using these compounds or compositions containing these compounds are also disclosed.

专利号:US-8389703-B1
优先权日:2004-08-28
标 题 :Ribonucleoside analogs with novel hydrogen bonding patterns
发明人：BENNER STEVEN A; KIM HYO-JOONG
权利人:BENNER STEVEN A; KIM HYO-JOONG
摘要:This invention relates to nucleoside, nucleotide, and oligonucleotide analogs that incorporate non-standard nucleobase analogs, defined to be those that present a pattern of hydrogen bonds to a paired nucleobase analog in a complementary strand that is different from the pattern presented by adenine, guanine, cytosine, and thymine. The invention is specifically concerned with nucleotide analogs that present the donor-donor-acceptor, hydrogen bonding patterns on pyrimidine analogs, and especially those that are analogs of ribonucleotides, including protected ribonucleotides suitable for phosphoramidite-based synthesis of RNA. The heterocycles on these nucleoside analogs are aminopyridones that have electron withdrawing groups attached to the position analogous to the 5-position of the ring in standard pyrimidines, including nitro, cyano, and carboxylic acid derivatives.