CAS: 89-59-8; 4-Chloro-2-Nitrotoluene

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CAS号106-43-4 对氯甲苯 | CAS号10565-16-9 (4-Chlor-2-nitr... | CAS号88-72-2 邻硝基甲苯 | CAS号75508-74-6 5-chloro-2-meth... | CAS号89-61-2 2,5-二氯硝基苯 | CAS号108-24-7 乙酸酐 | CAS号108-88-3 甲苯 | CAS号70343-09-8 2,3-dinitro-4-m... | CAS号344749-24-2 6-chloro-3-meth... | CAS号40794-04-5 5-氯-2-甲基苯甲醚 | CAS号32943-25-2 3-氯亚氨基二苄 | CAS号37777-71-2 2-(4-氯-2-硝基苯基)乙酸 | CAS号17422-33-2 6-氯吲哚 | CAS号939-79-7 4-甲基-3-硝基氰苯 | CAS号78941-95-4 5-氯-8-甲基喹啉 | CAS号27034-51-1 6-氯吲哚-2-羧酸乙酯 | CAS号95-79-4 5-氯-2-甲基苯胺 | CAS号66941-45-5 5,5'-Dichloro-2... | CAS号6280-88-2 4-氯-2-硝基苯甲酸

2,5-二氯硝基苯置于二甲基亚砜,Sodium Chloride体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 24.0H,反应生成 4-氯-2-硝基甲苯
参考文献:Bis(Dealkoxycarbonylation) Of Nitroarylmalonates: A Facile Entry To Alkylated Nitroaromatics
标题:Bis(Dealkoxycarbonylation) Of Nitroarylmalonates: A Facile Entry To Alkylated Nitroaromatics
摘要:详细介绍了一种通过双脱羧反应从取代硝基芳基丙二酸酯制备烷基化硝基芳烃的简便方法.
DOI:10.1055/s-2000-8209

专利信息

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:US-4621160-A
优先权日:1983-06-23
标题 :Process for the chlorination of aromatic derivatives
发明人：DESBOIS MICHEL; DISDIER CAMILLE
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the chlorination of aromatic derivatives. The aromatic derivative is reacted with chlorine gas in liquid hydrofluoric acid. The products obtained are useful as intermediates for the synthesis of compounds having a plant-protecting or pharmaceutical activity.

专利号:US-2005176941-A1
优先权日:2002-02-13
标 题:Nucleoside analogues whose sugar moieties are bound in s-form and oligonucleotide derivatives comprising nucleotide analogues thereof
发明人：IMANISHI TAKESHI; OBIKA SATOSHI
摘要:Compounds of the following general formula (1) and salts thereof: n n nwhere A represents an alkylene group having 1 to 2 carbon atoms, etc.; B represents an aromatic heterocyclic group which may have a substituent, etc.; R 1 and R 2 each represent a hydrogen atom, a protective group for a hydroxyl group for synthesis of nucleic acid, a phosphate group, or —P(R 4 )R 5 [where R 4 and R 5 are the same or different, and each represent a hydroxyl group, a hydroxyl group protected with a protective group for synthesis of nucleic acid, a mercapto group, a mercapto group protected with a protective group for synthesis of nucleic acid, etc.]; and R 3 represents a hydrogen atom, a halogen atom, a hydroxyl group, a hydroxyl group protected with a protective group for synthesis of nucleic acid, etc. nThese compounds are useful for producing oligonucleotide analogues useful for the antisense method, antigene method, etc., and for producing their intermediates.

专利号:US-2012108800-A1
优先权日:2009-06-23
标题:Method for synthesizing nucleic acid
发明人：MURATA SHUMPEI; UMEMOTO TADASHI; MIYATA KENICHI; HAYASE YOJI
权利人:MURATA SHUMPEI; UMEMOTO TADASHI; MIYATA KENICHI; HAYASE YOJI
摘要:Provided is a new production method for the synthesis of an NC type nucleoside efficiently and conveniently in a high yield without unnecessary protecting group conversion steps. It relates to a step of producing a compound represented by the formula (II): n n n n n n n n n n or a salt thereof, by inverting a compound represented by the formula (I): n n n n n n n n n n and a method of producing a compound represented by the formula (III): n n n n n n n n n n or a salt thereof (wherein each symbol is as defined in the specification), which includes the step.

专利号:US-2011245484-A1
优先权日:2010-03-31
标 题 :Stereoselective synthesis of phosphorus containing actives

专利号:US-5763599-A
优先权日:1994-12-16
标题:Nucleoside derivatives with photolabile protective groups
发明人：PFLEIDERER WOLFGANG; GIEGRICH HEINER
权利人:PFLEIDERER WOLFGANG
摘要:The invention relates to nucleoside derivatives having photolabile protective groups of the general formula (I) ##STR1## in which R 1 â•?H, NO 2 , CN, OCH 3 , halogen or alkyl or alkoxyalkyl having 1 to 4 C atoms n R 2 â•?H, OCH 3 n R 3 â•?H, F, Cl, Br, NO 2 n R 4 â•?H, halogen, OCH 3 , or an alkyl radical having 1 to 4 C atoms n R 5 â•?H or a usual functional group for preparing oligonucleotides n R 6 â•?H, OH, halogen or XR 8 , where Xâ•?O or S and R 8 represents a protective group usual in nucleotide chemistry, n B=adenine, cytosine, guanine, thymine, uracil, 2,6-diaminopurin-9-yl, hypoxanthin-9-yl, 5-methylcytosin-1-yl, 5-amino-4-imidazolcarboxamid-1-yl, or 5-amino-4-imidazolcarboxamid-3-yl, where in the case of B=adenine, cytosine or guanine, the primary amino function optionally exhibits a permanent protective group. n These derivatives may be used for the light-controlled synthesis of oligonucleotides on a DNA chip.