CAS: 93-11-8; Naphthalene-2-Sulfonyl Chloride

• 英文名称Naphthalene-2-Sulfonyl Chloride
• 中文名称2-萘磺酰氯
• IUPAC名称naphthalene-2-sulfonyl chloride
• 其它别名2-Naphthalenylsulfonylchloride; 2-Naphthylsulfonyl chloride; Naphthalene-2-sulfonic acidchloride; b-Naphthalenesulf°Chloride; b-Naphthalenesulfonyl chloride; b-Naphthylsulfonyl chloride
• CAS编号93-11-8
• MFCD编号:MFCD00004087
• EINECS号:202-219-9
• FDA UNII编号:W3N8WRJ279
• 分子式:C10H7ClO2S
• 分子量:226.68
• 产品CID: 2463298
• 产品分类有机原料→分子砌块→芳环类化合物→萘类化合物

• 相似结构搜索
• InChIKey: OPECTNGATDYLSS-UHFFFAOYSA-N
• InChI=1S/C10H7ClO2S/c11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H…
• 计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数1.0

相似化合物

物理性质

• 熔点74-76°C
• 沸点147.7°C at 760 mmHg
• 闪点178.4±19.3 °C
• 密度1.4±0.1 g/cm3
• PSA:34.14
• LogP:2.7673
• 折射率1.643
• 蒸汽压0.0±0.8 mmHg at 25°C
• 溶解性Soluble In Toluene
• 敏感性易受潮
• 外观形态淡黄色至米色粉末
• 储存条件置于阴暗处,密封, 常温干燥保存
• 产品应用该化合物用于在新乳素硫酸盐高性能液相色谱分析期间进行校前衍生.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07 & GHS09;
  注释: Exclamation mark & Environment
• 危险类别皮肤腐蚀/刺激 类别2
  水生慢性毒性 类别2
  皮肤腐蚀 类别1B
  金属腐蚀物 类别1
  严重眼损伤 类别1
  Water-react. 3
  皮肤腐蚀 类别1C
• 警示词Warning(警告)
• 危险描述H315 |造成皮肤刺激.
  H411 |对水生生物有毒并具有长期持续影响.
  H314 |造成严重皮肤灼伤和眼损伤.
  H290 |可能对金属造成腐蚀.
  H318 |造成严重眼损伤.
  H261 |遇水放出易燃气体.
• 防范说明P234-P260-P264-P280-P301+P330+P331-P304+P340-P363-P390-P405-P406-P501
• 危险等级8
• UN编号3261.0
• 危险品标志C
• 包装等级Ⅱ
• 安全声明26-36/37/39-45-27
• 危险类别码34
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 2-Naphthalenesulfonyl Chloride 主要起始原料 Sodium 2-Naphthalenesulfonate
• 532-02-5 = 93-11-8
  反应条件:1.1 Reagents: Thionyl Chloride
  标题:Synthesis Of Some Naphthalene Sulfonohydrazides And Related Compounds Of Potential Biological Activity
  作者:Islam,A. M.; Abdel-Halim,A. M.; Salama,M. A.
  参考文献:Egyptian Journal Of Chemistry 日期:1987 卷标:29(4) 页码:405-31]
  
  120-18-3 = 93-11-8
  反应条件:1.1 Reagents: Hexachlorocyclotriphosphazene; 1 Min,25 °C1.2 Reagents: Potassium Chloride; 1 Min,25 °C
  标题:Tapc-Promoted Synthesis Of Sulfonyl Chlorides From Sulfonic Acids
  作者:Bahrami,Kiumars
  参考文献:Synlett 日期:2011 卷标:(18) 页码:2671-2674]
  
  91-60-1 = 93-11-8
  反应条件:1.1 Reagents: Titanium Tetrachloride,Hydrogen Peroxide Solvents: Acetonitrile,Water; 2 Min,25 °C1.2 Reagents: Water; Rt
  标题:Synthesis Of Sulfonyl Chlorides And Thiosulfonates From H2O2-Ticl4
  作者:Bahrami,Kiumars; Khodaei,Mohammad M.; Khaledian,Donya
  参考文献:Tetrahedron Letters 日期:2012 卷标:53(3) 页码:354-358]
  
  580-13-2 = 93-11-8
  反应条件:1.1 Solvents: Tetrahydrofuran1.2 Reagents: Butyllithium,Sulfur Dioxide Solvents: Tetrahydrofuran1.3 Reagents: Sulfuryl Chloride Solvents: Hexane
  标题:An Improved Synthesis Of Arenesulfonyl Chlorides From Aryl Halides
  作者:Hamada,Tatsuo; Yonemitsu,Osamu
  参考文献:Synthesis 日期:1986 卷标:(10) 页码:852-4]
  
  532-02-5 = 93-11-8
  反应条件:1.1 Reagents: Cyanuric Chloride Catalysts: 18-Crown-6 Solvents: Acetone; 20 H,Reflux
  标题:A New,Mild Preparation Of Sulfonyl Chlorides
  作者:Blotny,Grzegorz
  参考文献:Tetrahedron Letters 日期:2003 卷标:44(7) 页码:1499-1501]
  
  91-60-1 = 93-11-8
  反应条件:1.1 Reagents: Acetic Acid,1,3-Dichloro-5,5-Dimethylhydantoin Solvents: Acetonitrile,Water; < 10 °C; 30 Min,10 °C -> 20 °C; 1 H,20 °C; 30 °C1.2 Reagents: Sodium Bicarbonate Solvents: Dichloromethane; 0 °C; < 10 °C; 15 Min,5 °C
  标题:A Simple And Highly Effective Oxidative Chlorination Protocol For The Preparation Of Arenesulfonyl Chlorides
  作者:Pu,Yu-Ming; Christesen,Alan; Ku,Yi-Yin
  参考文献:Tetrahedron Letters 日期:2010 卷标:51(2) 页码:418-421]
  
  16023-36-2 = 93-11-8 [标题:Reaction Conditions
  标题:Molecular Structure And Estrogenic Activity. Xiv. α,α-Dimethyl-β-(6-Methylthio-2-Naphthyl)Valeric Acid
  作者:Jacques,Jean
  参考文献:Bulletin De La Societe Chimique De France 日期:1955 卷标:231 页码:231-6]
  
  16023-36-2 = 93-11-8
  反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dimethylformamide
  标题:A Method For The Catalyzed Preparation Of Carboxylic And Sulfonic Acid Chlorides With Thionyl Chloride
  作者:Bosshard,H. H.; Mory,R.; Schmid,M.; Zollinger,Hch.
  参考文献:Helvetica Chimica Acta 日期:1959 卷标:42 页码:1653-8]
  
  10151-46-9 = 93-11-8
  反应条件:1.1 Reagents: Chlorosuccinimide Solvents: Acetonitrile; 2 H,Rt
  标题:Facile Synthesis Of Sulfonyl Chlorides/bromides From Sulfonyl Hydrazides
  作者:Chen,Rongxiang; Xu,Shaohong; Shen,Fumin; Xu,Canran; Wang,Kaikai; Et Al
  参考文献:Molecules 日期:2021 卷标:26(18)]
  
  5586-15-2 = 93-11-8
  反应条件:1.1 Reagents: Potassium Chloride,Potassium Peroxymonosulfate Sulfate (2Khso5.Khso4.K2So4) Solvents: Water; 15 Min,Rt
  标题:Oxyhalogenation Of Thiols And Disulfides Into Sulfonyl Chlorides/bromides Using Oxone-Kx (X = Cl Or Br) In Water
  作者:Madabhushi,Sridhar; Jillella,Raveendra; Sriramoju,Vinodkumar; Singh,Rajpal
  参考文献:Green Chemistry 日期:2014 卷标:16(6) 页码:3125-3131]
  
  91-60-1 = 93-11-8
  反应条件:1.1 Reagents: Trichloroisocyanuric Acid,Tetrabutylammonium Chloride Solvents: Acetonitrile,Water; 1 - 2 Min,0 °C; 20 Min,Rt
  标题:Trichloroisocyanuric Acid (Tcca) And N-Chlorosuccinimide (Ncs) As Efficient Reagents For The Direct Oxidative Conversion Of Thiols And Disulfides To Sulfonyl Chlorides
  作者:Veisi,Hojat; Sedrpoushan,Alireza; Hemmati,Saba; Kordestani,Davood
  参考文献:Phosphorus 日期:2012 卷标:187(6) 页码:769-775]
  
  5586-15-2 = 93-11-8
  反应条件:1.1 Reagents: Tetrabutylammonium Chloride,N1,N1,N3,N3-Tetrachloro-1,3-Benzenedisulfonamide Solvents: Acetonitrile,Water; 1 - 2 Min,0 °C; 0 °C -> Rt; 20 Min,Rt
  标题:Poly(N,N'-Dichloro-N-Ethyl-Benzene-1,3-Disulfonamide) And N,N,N',N'-Tetrachlorobenzene-1,3-Disulfonamide As Efficient Reagents To Direct Oxidative Conversion Of Thiols And Disulfide To Sulfonyl Chlorides
  作者:Veisi,Hojat; Ghorbani-Vaghei,Ramin; Mahmoodi,Jafar
  参考文献:Bulletin Of The Korean Chemical Society 日期:2011 卷标:32(10) 页码:3692-3695]
  
  5586-15-2 = 93-11-8
  反应条件:1.1 Reagents: Hydrogen Peroxide,Zirconium Chloride (Zrcl4) Solvents: Acetonitrile,Water; < 1 Min,25 °C
  标题:A Novel,Practical Synthesis Of Sulfonyl Chlorides From Thiol And Disulfide Derivatives
  作者:Bahrami,Kiumars; Khodaei,Mohammad Mehdi; Soheilizad,Mehdi
  参考文献:Synlett 日期:2009 卷标:(17) 页码:2773-2776]
  
  91-60-1 = 93-11-8
  反应条件:1.1 Reagents: Hexachlorocyclotriphosphazene,Hydrogen Peroxide Solvents: Acetonitrile,Water; 12 Min,25 °C
  标题:A Practical Method For The Preparation Of Sulfonyl Chlorides And Sulfonamides From Thiols Using H2O2-Tapc Reagent System
  作者:Parnian,Rouhallah; Soleimani,Ebrahim; Bahrami,Kiumars
  参考文献:Chemistryselect 日期:2019 卷标:4(29) 页码:8554-8557]
  
  91-60-1 = 93-11-8
  反应条件:1.1 Reagents: Thionyl Chloride,Hydrogen Peroxide Solvents: Acetonitrile,Water; 1 Min,25 °C1.2 Reagents: Water Solvents: Water
  标题:Direct Conversion Of Thiols To Sulfonyl Chlorides And Sulfonamides
  作者:Bahrami,Kiumars; Khodaei,Mohammad M.; Soheilizad,Mehdi
  参考文献:Journal Of Organic Chemistry 日期:2009 卷标:74(24) 页码:9287-9291]
  
  91-60-1 = 93-11-8
  反应条件:1.1 Reagents: Acetic Acid,Diethylamine,1,3-Dichloro-5,5-Dimethylhydantoin,Water Solvents: Acetonitrile; 41 S,4 Bar,40 °C1.2 Reagents: Acetonitrile
  标题:A Continuous Flow Investigation Of Sulfonyl Chloride Synthesis Using N-Chloroamides: Optimization,Kinetics And Mechanism
  作者:Polterauer,Dominik; Roberge,Dominique M.; Hanselmann,Paul; Littich,Ryan; Hone,Christopher A.; Et Al
  参考文献:Reaction Chemistry & Engineering 日期:2022 卷标:7(12) 页码:2582-2592]
  
  532-02-5 = 93-11-8
  反应条件:1.1 Reagents: Phosphorus Oxychloride; 6 H,70 °C
  标题:Method For Synthesis Of 2-Naphthalenesulfonyl Chloride From Sodium 2-Naphthalenesulfonate And Phosphorus Oxychloride
  参考文献:China]
  
  91-60-1 = 93-11-8
  反应条件:1.1 Reagents: Sodium Dodecyl Sulfate,Hydrogen Peroxide,Phosphorus Oxychloride Solvents: Water; 40 Min,25 °C
  标题:Synthesis Of Sulfonyl Chlorides And Sulfonic Acids In Sds Micelles
  作者:Bahrami,Kiumars; Khodaei,Mohammad M.; Abbasi,Jamshid
  参考文献:Synthesis 日期:2012 卷标:44(2) 页码:316-322]
  
  91-60-1 = 93-11-8
  反应条件:1.1 Reagents: Chlorotrimethylsilane,Hydrogen Peroxide Solvents: Acetonitrile,Water; 3 Min,Rt
  标题:High Yielding Protocol For Direct Conversion Of Thiols To Sulfonyl Chlorides And Sulfonamides
  作者:Sohrabnezhad,Samira; Bahrami,Kiumars; Hakimpoor,Farahman
  参考文献:Journal Of Sulfur Chemistry 日期:2019 卷标:40(3) 页码:256-264]
  
  532-02-5 = 93-11-8
  反应条件:1.1 Reagents: Phosphorus Pentachloride,Calcium Chloride; 1 H,100 °C
  标题:Polymer Side-Chain Modification In Methacrylate And Styrene Copolymers Through Thiol-Thioester Dynamic Exchange
  作者:Fila,Karolina; Goliszek,Marta; Podkoscielna,Beata; Podgorski,Maciej
  参考文献:European Polymer Journal 日期:2020 卷标:136]
  
  = 93-11-8 + 85-46-1
  反应条件:1.1 Reagents: Chlorosulfonic Acid Solvents: 1,2-Dichloroethane; 50 °C; 50 °C -> 80 °C; 1 H,80 °C
  标题:Preparation And Characterization Of Thiophenol Compounds
  作者:Feng,Baicheng; Et Al
  参考文献:Qingdao Keji Daxue Xuebao 日期:2011 卷标:32(3) 页码:252-255

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