CAS: 154212-60-9; 2-Isopropyl-4-(Methylaminomethyl)Thiazole

相似化合物

1185167-55-8 1171981-10-4 908591-25-3

上下游产品

CAS号40516-57-2 4-(氯甲基)-2-异丙基噻唑 | CAS号74-89-5 氨基甲烷 | CAS号3364-78-1 2-氯甲基噻唑 | CAS号534-07-6 1,3-二氯丙酮 | CAS号13515-65-6 2-甲基硫代丙酰胺 | CAS号908591-25-3 2-异丙基-4(((N-甲基)... | CAS号154212-61-0 (S)-2-(3-((2-异丙... | CAS号155213-67-5 利托那韦 | CAS号154248-99-4 N-((N-甲基-N-((2-...

2-Isopropyl-N-Methyl-1,3-Thiazole-4-Carboxamide置于硼烷四氢呋喃络合物体系中,用 四氢呋喃 用作溶剂,化学反应 12.0H,以81%的收率获得2-异丙基-4-(甲基氨基甲基)噻唑
参考文献:一种n-甲基-2-异丙基-4-噻唑甲胺的制备方法
标题:一种n-甲基-2-异丙基-4-噻唑甲胺的制备方法
摘要:本发明提供了一种n‑甲基‑2‑异丙基‑4‑噻唑甲胺的制备方法,涉及药物合成技术领域,解决了目前利托那韦中间体n‑甲基‑2‑异丙基‑4‑噻唑甲胺的制备方法存在着毒性较大,对环境不友好的技术问题.该制备方法包括下述步骤:(1)酰化‑环化反应;(2)芳构化‑取代反应;(3)还原反应.本发明提供的n‑甲基‑2‑异丙基‑4‑噻唑甲胺的制备方法,通过以便宜易得的异丁酰氯与半胱氨酸甲酯盐酸盐为原料;通过酰化‑环化反应,芳构化‑取代反应,还原反应三步合成了该化合物;与现有制备方法相比,具有绿色环保,易于规模化工业生产且收率高等优点,具有较好的应用前景.

专利信息

专利号:US-6407252-B1
优先权日:1999-09-21
标 题:Process for the synthesis of ritonavir
发明人：BELLANI PIETRO; FRIGERIO MARCO; CASTOLDI PATRIZIA
权利人:CLARIANT LSM ITALIA SPA
摘要:A process is described which permits the preparation of Ritonavir with only five intermediate stages using the same starting materials as those used in the process described in WO 94/14436; the process described here is also particularly satisfactory from the point of view of environmental impact because nearly all of the carbon atoms used are subsequently incorporated in the final molecule. Finally, the improvement afforded by this novel process is linked with the fact that an inexpensive reagent, such as bis-trichloromethyl carbonate (BTC), is used in two of the five stages.

专利号:JP-H1087639-A
优先权日:1992-12-29
标题:Useful intermediates for the synthesis of compounds that inhibit retroviral protease

专利号:CA-1217486-A
优先权日:1983-05-12
标题 :Synthesis of thiazoles

专利号:EP-1133485-B1
优先权日:1999-09-21
标题:A process for the synthesis of ritonavir

专利号:CN-105753806-A
优先权日:2016-02-02
标题 :A kind of heterogeneous synthesis method and application of ritonavir intermediate

专利号:CN-119241467-A
优先权日:2024-08-26
标题:Synthesis method of N- [ N-methyl-N- [ (2-isopropyl-4-thiazolyl) methyl ] aminocarbonyl ] -L-valine and methyl ester thereof