CAS: 164014-95-3; 1,4-Benzodioxane-6-Boronic Acid

相似化合物

517874-21-4 499769-88-9 493-09-4

6-溴-1,4-苯并恶烷置于盐酸,Palladium Bis[bis(Diphenylphosphino)Ferrocene] Dichloride,Potassium Acetate体系中,用 二甲基亚砜 用作溶剂,化学反应 3.25H,反应生成苯并-1,4-二氧六环-6-硼酸
参考文献:一种苯并杂环硼酸的制备方法
标题:一种苯并杂环硼酸的制备方法
摘要:本发明提供了一种苯并杂环硼酸的制备方法,所述制备方法包括以下步骤:(1)将式i所示苯并杂环化合物溶于溶剂a中,得到a溶液,将硼基化试剂溶于溶剂b中,得到b溶液,将钯催化剂和碱性试剂固载在连续流动反应器通道上,将a溶液与b溶液连续加料反应,流出反应管后终止反应得到中间体;(2)将步骤(1)得到的中间体经水解反应后得到所述苯并杂环硼酸;本发明所提供的制备方法,使用流动化学技术合成苯并杂环硼酸,相比于现有技术中的方法,本发明中产物的收率在86%以上,最高可达90%以上,产率非常高,并且反应速率快,大大降低了反应的能耗,并且可操作性高,自动化程度高,有利于生产操作,利于工业化生产.

专利信息

专利号:US-2009137557-A1
优先权日:2005-11-22
标题 :Calcilytic Compounds
发明人：KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
权利人:KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.

专利号:US-10202374-B2
优先权日:2014-02-27
标题 :6-aryl-4-phenylamino-quinazoline analogs as phosphoinositide-3-kinase inhibitors
发明人：VISHWAKARMA RAM ASREY; BHARATE SANDIP BIBISHAN; BHUSHAN SHASHI; YADAV RAMMOHAN RAO; GURU SANTOSH KUMAR; JOSHI PRASHANT
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to 6-aryl-4-phenylamino quinazolines of formula I wherein, R and R′ are as herein described. The present invention particularly relates to synthesis and anticancer and phoshpoinositide-3-kinase-α (PI3K-α) inhibitory activity. In addition, the invention relates to methods of using compounds for treating or preventing various cancers such as pancreatic, prostate, breast and melanoma.

专利号:US-11306103-B2
优先权日:2017-11-30
标题:Thieno[3,2-b]pyridine-5(4H)-one derivative compound, preparation method thereof and use thereof
发明人：LEE JONG SEOK; SUNG DAN BI; MUN BO HYUN; LEE HYI SEUNG; LEE YEON JU; LEE JI HOON; SHIN HEE JAE; PARK SOL
权利人:KOREA INST OCEAN SCI & TECH
摘要:The present invention relates to a novel thieno[3,2-b]pyridine-5(4H)-one derivative compound, a preparation method thereof, and a use thereof. The novel thieno[3,2-b]pyridine-5(4H)-one derivative compound according to the present invention is synthesized via an aza-[3+3] cyclization addition reaction using BOP, wherein the compound is obtained by synthesizing a 4-arylthiophen-3-amine in which aryl groups such as 4-piperidyl-C6H4, 4-pyrrolidyl-C6H4, 4-MeOC6H4, 3,4,5-(MeO)3C6H4, C6H5, 4-C6H5C6H4, and 4-F3COC6H4 are introduced via a synthesis process by a bromination reaction, a hydrolysis reaction, a decarboxylation reaction, and a Suzuki coupling reaction of methyl 3-aminothiophene carboxylate, and by synthesizing 4-arylthiophen-3-amine and mono-methyl fumarate via a formal aza-[3+3] cyclization addition reaction using BOP and conjugation. Accordingly, novel thieno[3,2-b]pyridine-5(4H)-one derivative compounds according to the present invention have fluorescence properties with a wide range of emission wavelengths and thus may be utilized in various industrial fields such as physics, chemistry, and biomedical research.