CAS: 2152628-33-4; 6-(2-Hydroxy-2-Methylpropoxy)-4-(6-(6-((6-Methoxypyridin-3-yl)Methyl)-3,6-Diazabicyclo[3.1.1]Heptan-3-yl)Pyridin-3-yl)Pyrazolo[1,5-A]Pyridine-3-Carbonitrile

上下游产品

Tert-Butyl 3-(5-(3-Cyano-6-(2-Hydroxy-2-Methylpropoxy)Pyrazolo[1,5-A]Pyridin-4-yl)Pyridin-2-yl)-3,6-Diazabicyclo[3.1.1]Heptane-6-Carboxylate

3-溴-5-甲氧基吡啶置于1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物,硫酸,水,Potassium Acetate,三乙酰氧基硼氢化钠,Potassium Carbonate,Caesium Carbonate,三乙胺,N,N-二异丙基乙胺,Sodium Hydroxide,十二硫醇体系中,用 四氢呋喃,1,4-二氧六环,二氯甲烷,水,二甲基亚砜,N,N-二甲基甲酰胺,异丙醇,乙腈 用作溶剂,化学反应 129.0H,反应生成塞卡替尼
参考文献:Process For The Preparation Of 6-(2-Hydroxy-2-Methylpropoxy)-4-(6-(6-((6-Methoxypyridin-3-yl)Methyl)-3,6-Diazabicyclo[3.1.1]Heptan-3-yl)Pyridin-3-yl)Pyrazolo[1,5-A]Pyridine-3-Carbonitrile
标题:Process For The Preparation Of 6-(2-Hydroxy-2-Methylpropoxy)-4-(6-(6-((6-Methoxypyridin-3-yl)Methyl)-3,6-Diazabicyclo[3.1.1]Heptan-3-yl)Pyridin-3-yl)Pyrazolo[1,5-A]Pyridine-3-Carbonitrile
摘要:在某些实施例中,本文提供了一种制备如本文所述的公式i化合物或其药用可接受盐的过程.

专利信息

专利号:US-6133409-A
优先权日:1996-12-19
标 题:Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
发明人：SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F
权利人:AVENTIS PHARM PROD INC
摘要:This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and alpha , beta -unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

专利号:US-3959322-A
优先权日:1960-09-22
标 题:Synthesis of 13-alkyl-gon-4-ones
发明人：HUGHES GORDON ALAN; SMITH HERCHEL
权利人:SMITH HERCHEL
摘要:The preparation of 13-methylgon-4-enes and novel 13-polycarbonalkylgon-4-enes by a new total synthesis is described. 13-Alkylgon-4-enes having progestational, anabolic and androgenic activities are prepared by forming a tetracylic gonane structure unsaturated in the 1,3,5(10),9(11) and 14-positions, selectively reducing in the B- and C-rings, and converting the aromatic A-ring compounds so-produced to gon-4-enes by Birch reduction and hydrolysis.

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-5656634-A
优先权日:1991-03-21
标题 :N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
发明人：CHANG GEORGE; HAMANAKA ERNEST S; MCCARTHY PETER A; TRUONG THIEN V; WALKER FREDERICK J
权利人:PFIZER
摘要:Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R 1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.

专利号:WO-2011032359-A1
优先权日:2009-09-17
标题:Momordica charantia peptide mc-jj6 and microwave promoted solid phase synthesis method thereof
发明人：HUANG WENLONG; JIN JING; QIAN HAI; ZHANG HUIBIN; CHEN WEI; WANG JINGJIE; DU KUO
权利人:UNIV CHINA PHARMA; HUANG WENLONG; JIN JING; QIAN HAI; ZHANG HUIBIN; CHEN WEI; WANG JINGJIE; DU KUO
摘要:Provided are peptides MC-JJ6 and MC-JJ6222 from Momordica charantia with hypoglycemic activity and a microwave promoted solid phase synthesis method thereof. The peptides MC-JJ6 and MC-JJ6222 comprise the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 115, respectively.

专利号:WO-2011032360-A1
优先权日:2009-09-17
标 题:Momordica charantia peptide mc-jj2 and microwave promoted solid phase synthesis method thereof
发明人：HUANG WENLONG; JIN JING; QIAN HAI; ZHANG HUIBIN; CHEN WEI; WANG JINGJIE; DU KUO
权利人:UNIV CHINA PHARMA; HUANG WENLONG; JIN JING; QIAN HAI; ZHANG HUIBIN; CHEN WEI; WANG JINGJIE; DU KUO
摘要:Provided are peptides MC-JJ2 and MC-JJ2163 from Momordica charantia with hypoglycemic activity and a microwave promoted solid phase synthesis method thereof. The peptides MC-JJ2 and MC-JJ2163 comprise the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 108, respectively.