CAS: 2277-28-3; (9Z,12Z)-2,3-Dihydroxypropyl Octadeca-9,12-Dienoate

上下游产品

甘油三亚油酸酯 1,2,3-Tri(Cis,Cis-9,12-Octadecadienoyloxy)Propane 537-40-6
2-亚麻酰基-Rac-甘油 2-Linoleoyl Glycerol 3443-82-1
亚油酸甲酯 Methyl Linoleate 112-63-0
Vinyl Linoleate 3234-56-8
1-亚麻酰-2,3-异亚丙基-外消旋-甘油 1,2-Acetonide-3-(9,12-Octadecadienoyl)Glycerol 127592-95-4
(Z,Z)-9,12-十八烷二烯酸二聚物 Linoleic Acid 60-33-3

(Z,Z)-9,12-十八烷二烯酸二聚物置于4-二甲氨基吡啶,水,溶剂黄146,N,N'-二环己基碳二亚胺体系中,用 二氯甲烷 用作溶剂,化学反应 0.5H,反应生成甘油单亚油酸酯
参考文献:信息素合成.第253部分:果蝇雄性果蝇甘油三酸酯的外消旋物和对映体的合成,特别着重于对映体纯的1-甘油单酸酯的制备
标题:信息素合成.第253部分:果蝇雄性果蝇甘油三酸酯的外消旋物和对映体的合成,特别着重于对映体纯的1-甘油单酸酯的制备
摘要:蝇果蝇的果蝇的外消旋体和对映异构体(2,3-丙酮甘油的外消旋体和对映异构体)通过三个步骤合成了甘油三酸酯1A-E(果蝇的果蝇的棕榈酸,棕榈油酸,硬脂酸,油酸和亚油酸的2,3-二聚二羟甲氧基丙基酯).(2)通过1-甘油单酸酯4A-E衍生自上述脂肪酸.建立了制备对映体纯的1-甘油单酸酯4A-E的适当条件,并通过相应的bis-(R)-Mtpa酯的NMR分析确定了它们的对映体纯度.
Doi:10.1016/j.Tet.2012.07.086

专利信息

专利号:US-8729283-B2
优先权日:2009-01-29
标 题 :Chain-selective synthesis of fuel components and chemical feedstocks
发明人：OLSON EDWIN S
权利人:ENERGY & ENVIRON RES CT FOUND
摘要:A method comprising providing a starting composition comprising a polyunsaturated fatty acid, a polyunsaturated fatty ester, a carboxylate salt of a polyunsaturated fatty acid, a polyunsaturated triglyceride, or a mixture thereof; self-metathesizing the starting composition or cross-metathesizing the starting composition with at least one short-chain olefin in the presence of a metathesis catalyst to form self-/cross-metathesis products comprising: cyclohexadiene; at least one olefin; and one or more acid-, ester-, or salt-functionalized alkene; and reacting cyclohexadiene to produce at least one cycloalkane or cycloalkane derivatives. A method for producing cycloalkanes for jet fuel by providing a starting composition comprising at least one selected from the group consisting of algal and polyunsaturated vegetable oils, subjecting the starting composition to metathesis to produce metathesis product comprising at least one olefin, cyclohexadiene, and at least one acid-, ester-, or salt-functionalized alkene, and reacting the at least one olefin and cyclohexadiene to form cycloalkane(s).

专利号:US-12295961-B2
优先权日:2009-12-31
标 题:Modulation of solubility, stability, absorption, metabolism, and pharmacokinetic profile of lipophilic drugs by sterols
发明人：DHINGRA OM
权利人:MARIUS PHARMACEUTICALS INC
摘要:A formulation for drug delivery, providing enhanced modulation of solubility, stability, absorption, metabolism, and/or pharmacokinetic profile of a lipophilic therapeutic agent by formulation with sterols and/or sterol esters, resulting in higher bioavailability of a therapeutic agent administered to a subject in need of such therapeutic agent. The formulation contains a therapeutic agent and a sterol or sterol ester, and can, optionally, further contain a solubilizer and/or an enhancing agent. Also described are pharmaceutical compositions containing the formulations and methods of making and methods of using the formulations and pharmaceutical compositions. Formulations of the disclosure can be constituted to minimize the synthesis of dihydrotestosterone when the therapeutic agent includes testosterone or testosterone esters.

专利号:WO-2023213264-A1
优先权日:2022-05-05
标 题 :Synthesis of amide compound and use thereof
发明人：WANG ZHAOYIN; ZHANG JIAN; CAO JINRUI
权利人:SHANGHAI INST ORGANIC CHEMISTRY CAS
摘要:The present invention relates to a novel oleanamide derivative for activating a KEAP/NRF2/ARE signaling pathway. The compound of the present invention is represented by general formula (I), wherein L, R 3 , R 4 , Z, and n are set forth in the description specification and the claims. Also disclosed are a method for preparing the compound represented by general formula I and an activity test result thereof for activating the KEAP/NRF2/ARE signaling pathway. The compound represented by general formula (I) of the present invention can be used for treating and preventing multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Friedreich's ataxia (FRDA), spinal muscular atrophy (SMA), neuromyelitis optica (NMO), spinocerebellar ataxia (SCA), and other neurodegenerative diseases, and can also be used for treating cerebral apoplexy, autoimmune diseases, diabetes, kidney diseases, and other chronic diseases.

专利号:US-11617758-B2
优先权日:2009-12-31
标 题 :Emulsion formulations
发明人：DHINGRA OM; BERNSTEIN JAMES S
权利人:MARIUS PHARMACEUTICALS LLC
摘要:A SEDDS or SMEDDS or SNEDDS formulation for drug delivery of a lipophilic therapeutic agent, providing enhanced modulation of solubility, stability, absorption, metabolism, and/or pharmacokinetic profile of the therapeutic agent by formulation with a lipophilic surfactant, a hydrophilic surfactant, one or more solubilizers and, optionally, digestible oils, resulting in higher bioavailability of the therapeutic agent administered to a subject in need of such therapeutic agent. Also described are pharmaceutical compositions containing the formulations and methods of making and methods of using the formulations and pharmaceutical compositions. Formulations of the disclosure can be constituted to minimize the synthesis of dihydrotestosterone when the therapeutic agent includes testosterone or testosterone esters.

专利号:EP-1414419-B1
优先权日:2001-07-26
标题:Pharmaceutical formulations comprising a cortisol synthesis inhibitor
发明人：LJUSBERG BARBRO HELENA; HYLEN SUSANNE VERONICA; FYGE ASA HELEN
权利人:CORTENDO AB
摘要:The present invention relates to pharmaceutical compositions comprising ketoconazole or a derivative thereof, one or more low melting point lipid excipients and a sufficient quantity of one or more high melting point lipid excipients to provide a liquid and a solid phase within said composition after heating to 35° C. for 18 hours more particularly to pharmaceutical compositions comprising ketoconazole or a derivative thereof and a lipid excipient, at least 85% by weight of said lipid excipient consisting or one or more low melting point lipids and 1-15% by weight of said lipid excipient consisting of one or more high melting point lipids, polymeric excipients are also described as are the use of these formulations in the treatment of metabolic syndrome and related conditions.

专利号:WO-2010123589-A2
优先权日:2009-01-29
标题:Chain-selective synthesis of fuel components and chemical feedstocks