2-氯-6-氟-苯甲醛置于四苯基溴化膦 Potassium Fluoride体系中,用 Chlorobrnzene 作为反应溶剂,化学反应 24.0H,反应生成 2,6-二氟苯甲醛 参考文献:[de] Verfahren Zur Herstellung Von Fluor Enthaltenden Verbindungen über Fluor-Halogenaustausch Durch Spezielle Polyaminophosphazen-Katalysatoren Method For Producing A Compound Containing Fluorine Via Fluorine-Halogen Exchange By Special Polyamino Phosphazene Catalysts[fr] Procede De Fabrication De Composes Contenant Du Fluor Par Echange Fluor-Halogene A L'Aide De Catalyseurs Polyaminophosphases Specifiques 标题:[de] Verfahren Zur Herstellung Von Fluor Enthaltenden Verbindungen über Fluor-Halogenaustausch Durch Spezielle Polyaminophosphazen-Katalysatoren Method For Producing A Compound Containing Fluorine Via Fluorine-Halogen Exchange By Special Polyamino Phosphazene Catalysts[fr] Procede De Fabrication De Composes Contenant Du Fluor Par Echange Fluor-Halogene A L'Aide De Catalyseurs Polyaminophosphases Specifiques 摘要:含氟化合物的硬化方法,通过将含有可与氟交换的卤素的化合物与一种氟化物或氟化物混合物按照下式(I)的普遍公式进行反应来实现,Mef (I),其中对于一种碱土金属离子,Nh4+ 离子或碱金属离子,以及存在或不存在溶剂的情况下,在60至260oc的温度下进行,其特征在于在一种化合物或化合物组合物的存在下进行反应,该化合物或化合物组合物具有下式(Iia)和/或(Iib)的普遍公式.公式ii A 公式ii B 公式ii C,其中x1和/或x2和/或x3独立地具有下式(Iic)的基团或与权利要求中提及的其他基团相对应.
专利号:US-8202985-B2 优先权日:2005-10-31 标 题:Monomer compositions for the synthesis of polynucleotides, methods of synthesis, and methods of deprotection 发明人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H 权利人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H; AGILENT TECHNOLOGIES INC; UNIV COLORADO 摘要:Nucleotide monomers, polynucleotides, methods of making each, and methods of deprotecting each, are disclosed. An embodiment of the nucleotide monomer, among others, includes a nucleotide monomer having a heterobase protecting group selected from structures I through III as described herein. An embodiment of the polynucleotide, among others, includes a plurality of nucleotide moieties having a heterobase protecting group selected from one of structures I through III as described herein.
专利号:US-7759471-B2 优先权日:2005-10-31 标题 :Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection 发明人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINE; CARUTHERS MARVIN H 权利人:AGILENT TECHNOLOGIES INC; UNIV COLORADO 摘要:Nucleotide monomers, polynucleotides, methods of making each, methods of deprotecting each, and the like are disclosed herein.
专利号:US-2007100138-A1 优先权日:2005-10-31 标题:Monomer compositions for the synthesis of polynucleotides, methods of synthesis, and methods of deprotection
专利号:US-2007100136-A1 优先权日:2005-10-31 标题:Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection
专利号:EP-2001896-A2 优先权日:2006-03-23 标 题 :Monomer compositions for the synthesis of rna, methods of synthesis, and methods of deprotection
专利号:WO-2007112263-A2 优先权日:2006-03-23 标 题:Monomer compositions for the synthesis of rna, methods of synthesis, and methods of deprotection
参考文献:10.1107/s1600536811007070 摘要:Huang JD, Tang QQ, Chen XY, Ye Y, Wang Y. (1E,4E)-1,5-Bis(2,6-difluoro-phen-yl)penta-1,4-dien-3-one. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o758.