CAS: 7506-66-3; Cis-Hexahydro-1H-Isoindole-1,3(2H)-Dione

相似化合物

1444-94-6 1002359-81-0 117307-09-2

上下游产品

CAS号1469-48-3 顺式-1,2,3,6-四氢吩胺 | CAS号13149-00-3 六氢苯酐 | CAS号85-42-7 六氢苯酐 | CAS号4720-86-9 3,4,5,6-四氢邻苯二甲酰亚胺 | CAS号57-13-6 尿素 | CAS号21850-12-4 顺式-全氢异吲哚 | CAS号5691-20-3 顺-2-氨基-1-环己烷羧酸 | CAS号1470-99-1 顺式全氢异吲哚

专利信息

专利号:US-5736535-A
优先权日:1992-04-16
标 题:1-pyrimidinylacetamide compounds which are inhibitors of human leukocyte elastase
发明人：BERNSTEIN PETER ROBERT; EDWARDS PHILIP DUKE; SHAW ANDREW; SHENVI ASHOKKUMAR BHIKKAPPA; THOMAS ROYSTON MARTIN; VEALE CHRIS ALLAN; WARNER PETER; WOLANIN DONALD JOHN
权利人:ZENECA LTD
摘要:The present invention relates to certain novel substituted derivatives which are 1-pyrimidinylacetamide derivatives of formula I, ##STR1## which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted derivatives, processes for preparing the substituted derivatives, pharmaceutical compositions containing such substituted derivatives and methods for their use.

专利号:US-RE41614-E
优先权日:1998-09-30
标题 :Synthetic analogs of ecteinascidin-743
发明人：COREY ELIAS J
权利人:HARVARD COLLEGE
摘要:The present invention is directed to the synthesis and characterization of compounds having the formula: n n wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are each independently selected from the group consisting of H, OH, OR′, SH, SR′, SOR′, SO 2 R′, NO 2 , NH 2 , NHR′, N(R′) 2 , NHC(â•?O)R′ NHC( â•?O ) R′ , CN, halogen, â•?O, C(â•?O)H, C(â•?O)R′, CO 2 H, CO 2 R′, C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, and substituted or unsubstituted heteroaromatic; wherein each of the R′ groups is independently selected from the group consisting of H, OH, NH 2 , NO 2 , SH, CN, halogen, â•?O, C(â•?O)H, C(â•?O)CH 3 , CO 2 H, CO 2 CH 3 , C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, aryl, aralkyl, and heteroaromatic; wherein each dotted circle represents one, two or three optional double bonds; wherein R 7 and R 8 may be are joined into a carbocyclic or heterocyclic ring system; and wherein X 1 and X 2 are each independently defined as above for R 1 -R 8 R 1 - R 6 and R 9 , an each further includes specific preferred groups as defined herein.

专利号:US-5254558-A
优先权日:1991-08-15
标 题:Substituted 1,3-diazines as leukocyte elastase inhibitors
发明人：BERNSTEIN PETER R; EDWARDS PHILIP D; THOMAS ROYSTON M; VEALE CHRIS A; WARNER PETER; WOLANIN DONALD J
权利人:ICI PLC
摘要:The present invention relates to certain novel substituted heterocycles which are 1-pyrimidinylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted heterocycles, processes for preparing the substituted heterocycles, pharmaceutical compositions containing such substituted heterocycles and methods for their use.

专利号:US-6569859-B1
优先权日:2000-02-22
标题 :Synthetic analogs of ecteinascidin-743
发明人：COREY ELIAS J
权利人:HARVARD COLLEGE
摘要:The present invention is directed to the synthesis and characterization of compounds having the formula: n wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are each independently selected from the group consisting of H, OH, OR′, SH, SR′, SOR′, SO 2 R′, NO 2 , NH 2 , NHR′, N(R′) 2 , NHC(O)R′, CN, halogen, â•?O, C(â•?O)H, C(â•?O)R′, CO 2 H, CO 2 R′, C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, and substituted or unsubstituted heteroaromatic; n wherein each of the R′ groups is independently selected from the group consisting of H, OH, NH 2 , NO 2 , SH, CN, halogen, â•?O, C(â•?O)H, C(â•?O)CH 3 , CO 2 H, CO 2 CH 3 , C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, aryl, aralkyl, and heteroaromatic; n wherein each dotted circle represents one, two or three optional double bonds; n wherein R 7 and R 8 may be joined into a carbocyclic or heterocyclic ring system; and n wherein X 1 and X 2 are each independently defined as above for R 1 -R 8 , and each furher includes specific preferred groups as defined herein.

专利号:WO-9321213-A1
优先权日:1992-04-16
标题 :Alpha-aminoboronic acid peptides and their use as elastase inhibitors
发明人：BERNSTEIN PETER ROBERT; SHAW ANDREW; SHENVI ASHOKKUMAR BHIKKAPPA; THOMAS ROYSTON MARTIN; WARNER PETER; WOLANIN DONALD JOHN
权利人:ZENECA LTD
摘要:The present invention relates to certain novel heterocyclic derivatives which are 1-pyridylacetamide derivatives of formula (I), set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases on mammals in which (HLE) is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic derivatives, processes for preparing the heterocyclic derivatives, pharmaceutical compositions containing such heterocyclic derivatives and methods for their use.

专利号:US-5721222-A
优先权日:1992-04-16
标 题 :Heterocyclic ketones
发明人：BERNSTEIN PETER ROBERT; SHAW ANDREW; THOMAS ROYSTON MARTIN; VEALE CHRIS ALLAN; WARNER PETER; WOLANIN DONALD JOHN
权利人:ZENECA LTD
摘要:The present invention relates to certain novel heterocyclic ketones which are 1-pyridylacetamide ketones of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic ketones, processes for preparing the heterocyclic ketones, pharmaceutical compositions containing such heterocyclic ketones and methods for their use.