CAS: 87001-32-9; 4-(Benzyloxy)Benzenesulfonyl Chloride

该化合物是一种有机化合物,其特征是其子氯磺酰体功能组,以其在各种化学反应中具有反应性而闻名;该化合物的特征是附于一个苯环上的苯氧基组,增强了其在有机溶剂中的溶解性,并促进其化学稳定性;它一般视具体情况而定,是固体或液体,对水分敏感,可导致水解和形成全氟辛烷磺酸衍生物; 全氟氯化磺酰胺使其在有机合成中成为有价值的中间体,特别是在生产磺酰胺和其他含有磺酰胺的化合物方面; 此外,它可参与核分裂性替代反应,使其有助于药物和农用化学的开发;由于反应性,在干燥的大气中进行适当处理和储存,惰性大气对于防止降解和确保使用期间的安全至关重要.

英文名称4-(Benzyloxy)Benzenesulfonyl Chloride
中文名称4-(苄氧基)苯磺酰氯
IUPAC名称4-(benzyloxy)benzenesulfonyl chloride
其它别名4-(苯基甲氧基)苯磺酰氯; 4-(Phenylmethoxy)Benzenesulfonyl Chloride
CAS编号87001-32-9
MFCD编号:MFCD04035557
EINECS号:820-368-3
分子式:C13H11ClO3S
分子量:282.74
产品CID: 1874426
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: BRTDEKQMIKCPKH-UHFFFAOYSA-N
InChI=1S/C13H11ClO3S/c14-18(15,16)13-8-6-12(7-9-13)17-10-11-4-2-1-3-5-11/h1-9H,10H2…
计算化学: 氢键受体数3.0氢键供体数0可旋转键数4

MSDS等安全信息

GHS象形图
GHS符号GHS05;
注释: Corrosion
危险类别金属腐蚀物类别1
皮肤腐蚀类别1B
严重眼损伤类别1
皮肤致敏类别1
严重眼刺激类别2A
警示词Danger(危险)
危险描述H290 |可能对金属造成腐蚀.
H314 |造成严重皮肤灼伤和眼损伤.
H318 |造成严重眼损伤.
H317 |可能引起皮肤过敏反应.
H319 |造成严重眼刺激.
防范说明P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
危险等级8
UN编号3261.0
包装等级Ⅲ
安全声明26-36/37/39-36/37
危险类别码34-43

欧盟法规

C&L通报

上下游产品

4-phenylmethoxybenzenesulfonic acid sodium salt 4-(benzyloxy)benzenesulfonic acid benzyl bromide sodium p-hydroxybenzenesulfonate 1-(4-benzyloxyphenylsulphonyl)-5-ethoxypyrrolidin-2-one (1R,5S)-2-(4-Benzyloxy-benzenesulfonyl)-6-oxa-2-aza-bicyclo[3.2.1]°Ctan-7-one tert-butyl ester[3-(4-benzyloxy-benzenesulfonylamino)-propyl]-(1-cyclohexylmethyl-piperidin-4-yl)-carbamic acid tert-butyl ester (R)-(4-Benzyloxy-benzenesulfonylamino)-((4S,5R,4'S)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-acetic acid methyl ester

合成工艺路线路线简述

825-90-1 = 87001-32-9
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Isopropanol,Water; 20 H,75 °C2.1 Reagents: Thionyl Chloride Catalysts: Dimethylformamide; Rt; 5 Min,Rt2.2 Solvents: Water; 5 Min,0 °C
标题:Fragment-Based Design,Synthesis,And Biological Evaluation Of 1-Substituted-Indole-2-Carboxylic Acids As Selective Mcl-1 Inhibitors
作者:Wang,Ziqian; Et Al
参考文献:Archiv Der Pharmazie (Weinheim 日期:2017 卷标:350(1)]

825-90-1 = 87001-32-9
反应条件:1.1 Reagents: Sodium Hydride Solvents: Dimethylformamide; Rt -> -10 °C1.2 6 H,Rt1.3 Reagents: Ethyl Acetate; Rt2.1 Reagents: Thionyl Chloride Solvents: Dimethylformamide; 0 °C; 2 H,Rt
标题:Fluorescent Non-Peptidic Rgd Mimetics With High Selectivity For αvβ3 Vs. αiibβ3 Integrin Receptor: Novel Probes For In Vivo Optical Imaging
作者:Alsibai,Wael; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2014 卷标:57(23) 页码:9971-9982]

5950-16-3 = 87001-32-9
反应条件:1.1 Reagents: Phosphorus Pentachloride Solvents: Dichloromethane; 24 H,40 °C
标题:Novel And Potent Anti-Malarial Agents
作者:Brinner,Kristin M.; Et Al
参考文献:Bioorganic & Medicinal Chemistry 日期:2002 卷标:10(11) 页码:3649-3661]

5950-16-3 = 87001-32-9
反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dimethylformamide; 0 °C; 2 H,Rt
标题:Fluorescent Non-Peptidic Rgd Mimetics With High Selectivity For αvβ3 Vs. αiibβ3 Integrin Receptor: Novel Probes For In Vivo Optical Imaging
作者:Alsibai,Wael; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2014 卷标:57(23) 页码:9971-9982]

111712-04-0 = 87001-32-9
反应条件:1.1 Reagents: Phosphorus Pentachloride Solvents: Dichloromethane; 24 H,40 °C
标题:Asymmetric Transfer Hydrogenation Of Ketones With A Polyethylene Glycol Bound Ru Catalyst In Water
作者:Liu,Juntao; Et Al
参考文献:Tetrahedron: Asymmetry 日期:2008 卷标:19(7) 页码:832-837]

111712-04-0 = 87001-32-9
反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dimethylformamide; Rt; 5 Min,Rt1.2 Solvents: Water; 5 Min
标题:Sulfone-Mediated Synthesis Of Substituted Furans On Solid Support
作者:Arvanitis,Elena A.; Et Al
参考文献:Arkivoc (Gainesville 日期:2002 卷标:(9) 页码:19-27]

111712-04-0 = 87001-32-9
反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dimethylformamide
标题:Sulfone-Mediated Synthesis Of Heterocycles On Solid Support
作者:Arvanitis,Elena Alexia
参考文献:1999]

94-02-0 = 87001-32-9
反应条件:1.1 Reagents: Potassium Carbonate,Dibenzo-18-Crown-6 Solvents: Acetone; 48 H,Reflux2.1 Catalysts: Dimethylformamide Solvents: Thionyl Chloride; 0 °C; 2 H,60 °C
标题:Preparation Of Polymer-Supported Ru-Tsdpen Catalysts And Use For Enantioselective Synthesis Of (S)-Fluoxetine
作者:Li,Yangzhou; Et Al
参考文献:Organic & Biomolecular Chemistry 日期:2005 卷标:3(14) 页码:2513-2518

(Benzyloxy)Benzene置于sulfur Trioxide N,N-Dimethylformamide Complex,氯化亚砜体系中,用二氯甲烷作为反应溶剂,化学反应 3.0H,反应生成 4-(苄氧基)苯-1-磺酰氯
参考文献:Beta-Sulfonamide Hydroxamic Acid Inhibitors Of Tace/matrix Metalloproteinase
标题:Beta-Sulfonamide Hydroxamic Acid Inhibitors Of Tace/matrix Metalloproteinase
摘要:这项发明提供了具有结构的formula I的化合物,这些化合物在治疗由tnf-α介导的疾病或紊乱方面非常有用,如关节炎(类风湿关节炎(ra),幼年ra,银屑病性关节炎,骨关节炎等),肿瘤转移,组织溃疡,异常伤口愈合,牙周病,骨病,糖尿病(胰岛素抵抗)和hiv感染,强直性脊柱炎,银屑病,败血症,多发性硬化,克罗恩病,退行性软骨丢失,哮喘,特发性肺纤维化,血管炎,系统性红斑狼疮,肠易激综合征,急性冠状动脉综合征,丙型肝炎,虚弱,慢性阻塞性肺病,中风或2型糖尿病的缓解症状.该发明还提供了使用这些化合物的方法.

海关参考信息

2902300000-甲苯
2905110000-甲醇
2906210000-苄醇
2908199090-其他酚的卤化衍生物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:WO-2010039911-A1
优先权日:2008-10-01
标题 :Calcilytic compounds
发明人：JEONG JAE U; MARQUIS ROBERT W JR
权利人:GLAXOSMITHKLINE LLC; JEONG JAE U; MARQUIS ROBERT W JR
摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.

专利号:RU-2104268-C1
优先权日:1991-08-02
标题:Indoline derivatives, method of their synthesis, intermediate compounds, pharmaceutical composition

专利号:ES-2501640-T3
优先权日:2009-06-30
标题:Benzenesulfonamide compounds, their method of synthesis and their use in medicine