
MSDS等安全信息
- GHS符号GHS07
- 危险类别水生慢性毒性 类别3
严重眼损伤 类别1 - 警示词Warning
- 危险描述H412 |对水生生物有害并具有长期持续影响.
H318 |造成严重眼损伤. - 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
- 安全声明IDENTIFICATION AND USE: Chromium trihydroxide (chromic acid) is a green, gelatinous precipitate. It is used as pigment, e.g. Guignet's green; in tanning industry; as a mordant, and as catalyst for organic reactions. HUMAN EXPOSURE AND TOXICITY: Fatal case was described involving 35-year-old woman who developed severe acidosis, massive gastrointestinal hemorrhage, acute renal failure, and hepatic injury following ingestion of chromic acid (50 mL) and died 12 hours after ingestion. Postmortem liver biopsy revealed a fatty degeneration with chromium concentration 3.6 umol/g. The kidney, with chromium concentration 2.6 umol/g, had extensive necrosis and ischemic lesions. Changes in renal function among ferrochromium workers in a ferroalloy facility in China were investigated (exposed to chromium compounds such a sodium-chromate and chromium-hydroxide). The results of this study suggest that long-term exposure to chromium produces chronic renal injury, mainly involving the proximal tubule. A urinary chromium concentration of greater than 15 ug/g of creatinine can be proposed as a threshold dosage for nephrotoxicity, and gamma-glutamyl-transferase, NAG and alkaline-phosphatase are all early sensitive indicators of renal injury. ANIMAL STUDIES: There is no data available. | Trivalent chromium may also form complexes with peptides, proteins, and DNA, resulting in DNA-protein crosslinks, DNA strand breaks, DNA-DNA interstrand crosslinks, chromium-DNA adducts, chromosomal aberrations and alterations in cellular signaling pathways. It has been shown to induce carcinogenesis by overstimulating cellular regulatory pathways and increasing peroxide levels by activating certain mitogen-activated protein kinases. It can also cause transcriptional repression by cross-linking histone deacetylase 1-DNA methyltransferase 1 complexes to CYP1A1 promoter chromatin, inhibiting histone modification. Chromium may increase its own toxicity by modifying metal regulatory transcription factor 1, causing the inhibition of zinc-induced metallothionein transcription. (A12, L16, A34, A35, A36)
- 危险类别码CrIII compounds do not cause chrome ulcerations but may cause allergic dermatitis in workers with prior sensitization to CrVI compounds. [ILO Encyclo] CrIII is an essential trace mineral in the human diet. [ATSDR Case Studies] An eye irritant; [ICSC] A powerful skin, eye, and mucous membrane irritant; [HSDB] See Chromium.
欧盟法规
REACH注册ECHA物质ECHA物质C&L通报REACH预注册专利信息
专利号:US-2023286918-A1
优先权日:2020-07-02
标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat
发明人:JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER
权利人:AKEBIA THERAPEUTICS INC
摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.
专利号:US-7405313-B2
优先权日:2006-09-13
标题:Method for the synthesis of basic chromium carboxylates
发明人:VINCENT JOHN B
权利人:UNIV ALABAMA
摘要:A method for the synthesis of a chromium complex 2, [Cr 3 O(carboxylate) 6 (H 2 O) 3 ] + (2), wherein carboxylate is a substituted or unsubstituted C2-C5 alkyl carboxylate, is provided, including the step of: n heating an aqueous reaction mixture of a Cr(III) salt, a substituted or unsubstituted C2-C5 alkyl carboxylic acid and a metal hydroxide for a time period and at a temperature sufficient to generate an aqueous product mixture comprising chromium complex 2 and non-toxic byproducts.
专利号:US-4666945-A
优先权日:1983-11-14
标 题:Catalyst composition suitable for synthesis of methanol
发明人:OSUGI MINORU; TAKAGAWA MAKOTO; NAKAMURA TADASI; KOJIMA TAKASHI; TSUJI KINYA
权利人:MITSUBISHI GAS CHEMICAL CO
摘要:A catalyst composition comprising copper oxide, zinc oxide and zirconium oxide, the content of zirconium oxide being 30 to 70% by weight. This catalyst composition is useful for synthesis of methanol from carbon monoxide and/or carbon dioxide and hydrogen by a gas-liquid-solid phase fluidized bed method or a gas-solid phase fluidized bed method.
专利号:US-2023114534-A1
优先权日:2021-10-11
标题:High Temperature Chemical Process For The Preparation Of Cesium Tungstate
发明人:CARDARELLI FRANCOIS
权利人:CARDARELLI FRANCOIS
摘要:The present disclosure broadly relates to a high temperature chemical process for the synthesis of cesium tungstate in the solid state and the preparation of aqueous solutions or deuterated solutions of cesium tungstate. More specifically, but not exclusively, the present disclosure relates to a high temperature chemical process in which tungsten oxide compounds such as tungsten oxides, or natural or synthetic concentrates such as wolframite or scheelite, tungsten industrial by-products or there mixture thereof, are mixed with cesium compounds such as cesium carbonate, or cesium sulfate, or cesium hydroxide or their mixtures thereof and the mixture is roasted in air or oxygen at high temperature inside a kiln. After cooling, the solid sintered mass containing cesium tungstate is leached or dissolved with water or heavy water for producing dense aqueous solutions or deuterated solutions of cesium tungstate.
专利号:US-2007287877-A1
优先权日:2006-06-12
标题 :Method for synthesis of reversion resistant chromium bearing wastes and materials
发明人:FORRESTER KEITH EDWARD
权利人:FORRESTER KEITH EDWARD
摘要:This invention provides a method for stabilization of hexavalent chromium and trivalent chromium bearing wastes, materials, and contaminated soils subject to acid and water leaching tests or leach conditions by addition of water solution, hexavalent chromium reducing agent, precipitating and pH increase agent, and chromium reversion control and stabilizing agents such that leaching of chromium is inhibited to desired levels and resists reversion to hexavalent chromium form over time. The resultant material, contaminated soil and/or waste after stabilization and reversion control is deemed suitable for on-site reuse, off-site reuse or disposal as RCRA non-hazardous waste.
专利号:US-12312698-B2
优先权日:2022-12-23
标 题:Method and device for preparing trivalent chromium salt by electrochemical oxidation of ferrochrome in acidic system
发明人:LI BO; FENG HAITAO; DONG YAPING; LI XINQIAN; LI SHUQI; NIU ZHENGRONG; LI WU
权利人:QINGHAI INST SALT LAKES CAS
摘要:A method and a device for preparing a trivalent chromium salt by electrochemical oxidation of ferrochrome in an acidic system are provided. The method includes: putting ferrochrome as an anode and placing the anode into an acidic electrolyte together with a cathode, and then turning on a power supply for electrolysis reaction, until an electrolysis completion solution containing the trivalent chromium salt and a trivalent iron salt is directly prepared. Compared with the prior art, the one-step electrochemical synthesis of the trivalent chromium salt solution can be achieved without a hexavalent chromium salt stage, avoiding the generation of chromium-containing waste residue, shortening the process flow and significantly improving the production efficiency of the trivalent chromium salt; furthermore, the reaction can be carried out at room temperature and normal pressure without the use of fine chromium iron powders and a high-concentration acidic electrolyte.