CAS: 2002-59-7; 6-Thioxo-6,9-Dihydro-1H-Purin-2(3H)-One

该化合物是一种纯衍生物和含有硫的类似Xanthine,其特点是在Xanthine结构的6个位置上存在硫醇组,该化合物一般是白色至非白色固体,在水和各种有机溶剂中溶解,便于其在生化应用中使用;它具有类似于其他净化物的特性,参与各种生物过程,特别是核酸新陈代谢;6-Thioxanthine可以作为某些酶的基质,并可能影响涉及纯核酸核酸的代谢途径;其潜在的药理应用值得注意,特别是在核核素类模拟研究及其对细胞过程的影响方面.此外,该化合物的稳定性和再活性可能受到诸如pH和温度等环境条件的影响.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

2-chloro-1,7-dihydro-purine-6-thione xanthin 2,6-dichloro-7H-purine 6H-purine-6-thione 6-benzylmercapto-3,7-dihydro-purin-2-one 6-Thi°Coffein 3,7-dimethyl-6-thioxo-2-oxopurine 3,7-dimethyl-6-methylthio-2(3H)-purinone

合成工艺路线路线简述

    黄嘌呤置于吡啶,Tetraphosphorus Decasulfide体系中,化学反应生成6-硫代-2-羟基嘌呤
    参考文献:New Syntheses Of Purine
    标题:New Syntheses Of Purine
    摘要:
    Doi:10.1021/ja01651A010

    专利信息


    专利号:US-10337030-B2
    优先权日:2016-07-07
    标 题 :Microbially-mediated method for synthesis of metal chalcogenide nanoparticles
    发明人:MOON JI WON; PHELPS TOMMY JOE; OREMLAND RONALD; GRAHAM DAVID E; IVANOV ILIA N; JACOBS CHRISTOPHER B; JANG GYOUNG GUG; KIDDER MICHELLE K; JOSHI POORAN C; ARMSTRONG BETH L
    权利人:UT BATTELLE LLC; U S GEOLOGICAL SURVEY
    摘要:A method for producing metal chalcogenide nanoparticles, the method comprising: (i) producing hydrogen chalcogenide-containing vapor from a microbial source, wherein said microbial source comprises: (a) chalcogen-reducing microbes capable of producing hydrogen chalcogenide vapor from a chalcogen-containing source; (b) a culture medium suitable for sustaining said chalcogen-reducing microbes; (c) at least one chalcogen-containing compound that can be converted to hydrogen chalcogenide vapor by said chalcogen-reducing microbes; and (d) at least one nutritive compound that provides donatable electrons to said chalcogen-reducing microbes during consumption of the nutritive compound by said chalcogen-reducing microbes; and (ii) directing said hydrogen chalcogenide-containing vapor into a metal-containing solution comprising a metal salt dissolved in a solvent to produce metal chalcogenide nanoparticles in said solution, wherein said chalcogen is sulfur or selenium, and said chalcogenide is sulfide or selenide, respectively. The invention is also directed to metal chalcogenide nanoparticle compositions produced as above and having distinctive properties.

    专利号:US-9768333-B2
    优先权日:2009-02-03
    标题:Microbially-mediated method for synthesis of non-oxide semiconductor nanoparticles
    发明人:PHELPS TOMMY J; LAUF ROBERT J; MOON JI-WON; RONDINONE ADAM JUSTIN; LOVE LONNIE J; DUTY CHAD EDWARD; MADDEN ANDREW STEPHEN; LI YILIANG; IVANOV ILIA N; RAWN CLAUDIA JEANETTE
    权利人:UT BATTELLE LLC; UNIV TENNESSEE RES FOUND
    摘要:The invention is directed to a method for producing non-oxide semiconductor nanoparticles, the method comprising: (a) subjecting a combination of reaction components to conditions conducive to microbially-mediated formation of non-oxide semiconductor nanoparticles, wherein said combination of reaction components comprises i) anaerobic microbes, ii) a culture medium suitable for sustaining said anaerobic microbes, iii) a metal component comprising at least one type of metal ion, iv) a non-metal component comprising at least one non-metal selected from the group consisting of S, Se, Te, and As, and v) one or more electron donors that provide donatable electrons to said anaerobic microbes during consumption of the electron donor by said anaerobic microbes; and (b) isolating said non-oxide semiconductor nanoparticles, which contain at least one of said metal ions and at least one of said non-metals. The invention is also directed to non-oxide semiconductor nanoparticle compositions produced as above and having distinctive properties.

    专利号:US-8759053-B2
    优先权日:2009-02-03
    标 题 :Microbially-mediated method for synthesis of non-oxide semiconductor nanoparticles
    发明人:PHELPS TOMMY J; LAUF ROBERT J; MOON JI WON; RONDINONE ADAM J; LOVE LONNIE J; DUTY CHAD EDWARD; MADDEN ANDREW STEPHEN; LI YILIANG; IVANOV ILIA N; RAWN CLAUDIA JEANETTE
    权利人:PHELPS TOMMY J; LAUF ROBERT J; MOON JI WON; RONDINONE ADAM J; LOVE LONNIE J; DUTY CHAD EDWARD; MADDEN ANDREW STEPHEN; LI YILIANG; IVANOV ILIA N; RAWN CLAUDIA JEANETTE; UT BATTELLE LLC; UNIV TENNESSEE RES FOUNDATION
    摘要:The invention is directed to a method for producing non-oxide semiconductor nanoparticles, the method comprising: (a) subjecting a combination of reaction components to conditions conducive to microbially-mediated formation of non-oxide semiconductor nanoparticles, wherein said combination of reaction components comprises i) anaerobic microbes, ii) a culture medium suitable for sustaining said anaerobic microbes, iii) a metal component comprising at least one type of metal ion, iv) a non-metal component containing at least one non-metal selected from the group consisting of S, Se, Te, and As, and v) one or more electron donors that provide donatable electrons to said anaerobic microbes during consumption of the electron donor by said anaerobic microbes; and (b) isolating said non-oxide semiconductor nanoparticles, which contain at least one of said metal ions and at least one of said non-metals. The invention is also directed to non-oxide semiconductor nanoparticle compositions produced as above and having distinctive properties.

    专利号:US-5864037-A
    优先权日:1996-06-06
    标题:Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity

    专利号:WO-9746561-A1
    优先权日:1996-06-06
    标题:Improved methods for the synthesis of chemical compounds having pde-iv inhibitory activity

    专利号:WO-2012030642-A2
    优先权日:2010-09-02
    标 题:Microbially-mediated method for synthesis of non-oxide semiconductor nanoparticles
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    合成参考文献


    摘要:D. Lichtenberg, F. Bergmann and Z. Neiman, J. Chem. Soc., Perkin Trans. 2 1972, 1676.
    参考文献:10.1007/s00268-002-4053-5
    摘要:Yazawa K, Fisher WE, Brunicardi FC. Current progress in suicide gene therapy for cancer. World J Surg. 2002 Jul;26(7):783–9. doi: 10.1007/s00268-002-4053-5.
    参考文献:10.1074/jbc.m800261200
    摘要:Papakostas K, Georgopoulou E, Frillingos S. Cysteine-scanning analysis of putative helix XII in the YgfO xanthine permease: ILE-432 and ASN-430 are important. J Biol Chem. 2008 May 16;283(20):13666–78. doi: 10.1074/jbc.m800261200.
    参考文献:10.1007/s11306-022-01876-w
    摘要:Taylor EN, Beckmann M, Markey BK, Gordon SV, Hewinson G, Rooke D, Mur LAJ. Metabolomic changes in Mycobacterium avium subsp. paratuberculosis (MAP) challenged Holstein-Friesian cattle highlight the role of serum amino acids as indicators of immune system activation. Metabolomics. 2022 Mar 23;18(4):21.
    参考文献:10.1016/0006-2952(95)02070-5
    摘要:Naguib FN, Iltzsch MH, el Kouni MM, Panzica RP, el Kouni MH. Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii. Biochem Pharmacol. 1995 Nov 09;50(10):1685–93. doi: 10.1016/0006-2952(95)02070-5.
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