CAS: 324-94-7; 4'-Fluoro-[1,1'-Biphenyl]-4-Ol

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CAS号106-41-2 对溴苯酚 | CAS号1765-93-1 4-氟苯硼酸 | CAS号540-38-5 4-碘苯酚 | CAS号352-34-1 4-氟碘苯 | CAS号71597-85-8 4-羟基苯硼酸 | CAS号67963-68-2 (4-溴苯氧基)叔丁基二甲基硅烷 | CAS号159191-56-7 4-(叔丁基二甲硅氧基)苯硼酸 | CAS号352-33-0 对氯氟苯 | CAS号25244-30-8 1-(烯丙氧基)-4-溴苯

4-(叔丁基二甲基硅氧基)苯基硼酸置于四(三苯基膦)钯 四丁基氟化铵,Sodium Carbonate体系中,用 四氢呋喃,水,甲苯 作为反应溶剂,化学反应 2.08H,反应生成 4-氟-4'-羟基联苯
参考文献:Discovery Of Potent Nonpeptide Inhibitors Of Stromelysin Using Sar By NMR
标题:Discovery Of Potent Nonpeptide Inhibitors Of Stromelysin Using Sar By NMR
摘要:With The Use Of An NMR-Based Method,Potent (Ic50 < 25 Nm) Nonpeptide Inhibitors Of The Matrix Metalloproteinase Stromelysin (Mmp-3) Were Discovered. The Method,Called Sar By NMR (For Structure-Activity Relationships By Nuclear Magnetic Resonance),Involves The Identification,Optimization,And Linking Of Compounds That Bind To Proximal Sites On A Protein. Using This Technique,Two Ligands That Bind Weakly To Stromelysin (Acetohydroxamic Acid,K-D = 17 Mm; 3-(Cyanomethyl)-4'-Hydroxybiphenyl,K-D = 0.02 Mm) Were Identified. On The Basis Of NMR-Derived Structural Information,The Two Fragments Were Connected To Produce A 15 Nm Inhibitor Of This Enzyme. This Compound Was Rapidly Discovered (Less Than 6 Months) And Required Only A Minimal Amount Of Chemical Synthesis. These Studies Indicate That The Sar By NMR Method Can Be Effectively Applied To Enzymes To Yield Potent Lead Inhibitors-An Important Part Of The Drug Discovery Process.
DOI:10.1021/ja9702778

专利信息

专利号:US-3919155-A
优先权日:1970-12-18
标题:Synthesis of aromatic amines by reaction of aromatic compounds with ammonia
发明人：SQUIRE EDWARD NOONAN
权利人:DU PONT
摘要:An improved process for producing an aromatic amine is provided in which an aromatic compound is reacted with ammonia in the presence of a conditioned nickel/nickel oxide cataloreactant at a temperature of from about 150*C. to about 500*C. and at a pressure of from about 10 to about 1000 atmospheres and in the presence of from 1 mole percent to 250 mole percent of water based on the molar amount of the aromatic compound.

专利号:US-4031106-A
优先权日:1973-12-19
标题:Synthesis of aromatic amines by reaction of aromatic compounds with ammonia
发明人：DELPESCO THOMAS WAYNE
权利人:DU PONT
摘要:An improved process is provided for producing an aromatic amine from ammonia and an aromatic compound which comprises reacting the aromatic compound with ammonia at a temperature of from about 150 DEG C. to about 500 DEG C. and at a pressure of from about 10 to about 1000 atmospheres in the presence of a conditioned nickel/nickel oxide/zirconium oxide cataloreactant containing an oxide of lanthanum, samarium, holmium, europium, erbium, yttrium, praseodymium, neodymium, terbium, ytterbium, dysprosium or a mixture of any of them.

专利号:US-4001260-A
优先权日:1973-12-19
标 题:Synthesis of aromatic amines by reaction of aromatic compounds with ammonia
发明人：DEL PESCO THOMAS W
权利人:DU PONT
摘要:An improved process is provided for producing an aromatic amine from ammonia and an aromatic compound which comprises reacting the aromatic compound with ammonia at a temperature of from about 150° C. to about 500° C. and at a pressure of from about 10 to about 1000 atmospheres in the presence of a conditioned nickel/nickel oxide/zirconium oxide cataloreactant which has been treated with ammonia prior to introduction of the cataloreactant to the amination reactants.

专利号:CN-109721726-B
优先权日:2017-10-27
标 题:A kind of method for recycling polyarylene ether synthesis solvent

专利号:CN-113845492-B
优先权日:2021-09-28
标 题:A kind of method of phenol and amine direct coupling synthesis aromatic amine compound