CAS: 330-54-1; Diuron

该化合物是一种属于苯尿素类的系统性除草剂,主要用于控制各种农业环境中的多种杂草,其化学配方为C9H10ClN2O,其特点是它能够抑制植物中的光合作用,特别是堵塞光系统II中的电子运输链.Diuron一般是一种白色晶体,在水中溶解性较低,有助于其在环境中的持久性.它对于水生生物具有中度毒性,可能对非目标植物物种产生不利影响.由于它对环境的潜在影响,许多国家对diuron的使用实行管制,而且其应用往往受到具体准则的约束,以尽量减少生态风险.此外,在土壤和水中可以检测diuron,引起人们对其对生态系统和人类健康的长期影响的关切.适当的处理和应用做法对于减轻这些风险至关重要,同时有效地利用其杀菌特性.

结构式图片

欧盟法规

《欧盟PIC法规》统一分类与标签REACH注册ECHA物质欧盟农药活性物质食品接触材料-禁用CMR物质OtherC&L通报欧盟生物杀灭剂法规欧盟《生物杀灭剂法规》REACH预注册废弃物危险特性清单"欧盟管控危险化学品"工作场所安全标识要求ECHA物质化妆品禁用物质清单欧盟《水框架指令》附件XCoRAP评估清单

上下游产品

CAS号95-76-1 3,4-二氯苯胺 | CAS号79-44-7 二甲氨基甲酰氯 | CAS号7159-94-6 3, 4-二氯苯基氨基甲酸乙酯 | CAS号124-40-3 二甲胺 | CAS号2327-02-8 N-(3,4-二氯苯基)脲 | CAS号2150-28-9 ISOPROPYL (3,4-... | CAS号102-36-3 3,4-二氯苯异氰酸酯 | CAS号10248-88-1 3-(3,4-dichloro... | CAS号201230-82-2 carbon monoxide | CAS号74-89-5 氨基甲烷 | CAS号34637-13-3 1-(3-Chloro-4-h... | CAS号3567-62-2 N-(3,4-二氯苯基)-N-甲基尿素 | CAS号69342-26-3 N-(4-chloro-3-h... | CAS号76409-92-2 N-[(3,4-dichlor... | CAS号51207-31-9 2,4,7,8-四氯二苯并呋喃 | CAS号1746-01-6 硫丙磷 | CAS号124-38-9 二氧化碳 | CAS号95-76-1 3,4-二氯苯胺 | CAS号124-40-3 二甲胺

合成工艺路线路线简述

  • 合成目标产物 Diuron 主要起始原料 Dimethylamine And Isocyanic Acid 3,4-Dichlorophenyl Ester
  • (文献来源)合成步骤主要原料 Dimethylamine 和 Isocyanic Acid 3,4-Dichlorophenyl Ester
3-(3,4-二氯苯基)-1,1-二甲基硫脲置于sodium Chlorite体系中,化学反应 2.0H,以72%的收率获得敌草隆
参考文献:New Synthetic Strategy For Urea Herbicides
标题:New Synthetic Strategy For Urea Herbicides
摘要:This Work Describes An Effective And A Safe Procedure For The Preparation Of Commercially Applicable Trisubstituted Ureas Derived From Their Thio Analogues Which Result From The Thiuram Disulfides In Quantitative Yields.
Doi:10.1080/00397919708003392

海关参考信息

专利信息


专利号:US-7691968-B2
优先权日:2002-05-03
标题:Process for the synthesis of peptides amides by side-chain attachment to a solid phase
发明人:EVANS DAVID JOHN; SIMPKIN DEAN STEVEN ANTHONY; WELLINGS DONALD ALFRED; ATHERTON ERIC
权利人:AVECIA BIOLOG LTD
摘要:A process is provided for the solid-phase synthesis of a peptide amide which comprises attaching an α-nitrogen protected Cα-carboxamide amino acid to a solid support by its side chain, removing the α-nitrogen protecting group, assembling a peptide chain on said α-nitrogen and then cleaving the assembled peptide amide from the solid support. Novel amino acid analogues, peptide amides and solid-phase supports are also provided.

专利号:US-8546532-B2
优先权日:2008-04-17
标题:Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
发明人:BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS
权利人:BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS; DECLION PHARMACEUTICALS INC
摘要:The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.

专利号:WO-2017100796-A1
优先权日:2015-12-11
标 题 :Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers
发明人:WONG CHI-HUEY; HSU TSUI-LING; WU CHUNG-YI; CHEUNG SARAH K C; CHUANG PO-KAI
权利人:SINACA ACAD; WONG CHI-HUEY; HSU TSUI-LING
摘要:The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta- 4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for disgnostic and therapeutic uses.

专利号:US-2017283878-A1
优先权日:2015-12-11
标题:Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers
发明人:WONG CHI-HUEY; WU CHUNG-YI; CHEUNG SARAH K C; CHUANG PO-KAI; HSU TSUI-LING
权利人:ACADEMIA SINICA
摘要:The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for diagnostic and therapeutic uses.

专利号:US-9567610-B2
优先权日:2012-03-30
标 题:Use of Botrytis cinerea for obtaining gold nanoparticles
发明人:CASTRO RETAMAL MIGUEL; CASTILLO NARA ANTONIO
权利人:UNIV SANTIAGO CHILE
摘要:The present invention is related to the use of Botrytis cinerea strains, its spores, hyphae mycelium, sclerotia, intra and/or extracellular organic molecules, such as proteins, nucleic acids, polysaccharides, lipids and secondary metabolites for the biosynthesis of gold nanoparticles (AuNps). In general terms, the present invention is focused to use B. cinerea strains and/or molecules generated by this organism for the biological synthesis of AuNps, being then the field of application, the synthesis of nanomaterials, specifically AuNps using the phytopathogenic fungus B. cinerea and/or its intra or extracellular proteins purified individually or in combination thereof or any of other intra and/or extracellular molecule produced by this organism as a biological system of synthesis. The metallic nanoparticles are used in various applications including: semiconductors, photoluminescence, biomedicine, imaging for the medical diagnostic, catalysts (dispersed and supported) and in therapies against some types of neoplasia (cancer), among others.

专利号:US-2007004631-A1
优先权日:2005-06-30
标题:Method for synthesis of phospholipids-PEG-biomolecule conjugates
发明人:SIMPURA ILKKA
权利人:CTT CANCER TARGETING TECH OY
摘要:The present invention relates to methodology of manufacturing phospholipids-PEG-biomolecule conjugates suitable for use as a component of diagnostic or therapeutic liposomes/micelles in targeted diagnostics or therapy and concerns specifically a simple method of synthesis, purification and analysis of phospholipid biomolecule, e.g. peptide, conjugates. The invention thus provides micellar peptides, which can be used for improving targeting of liposomes/micelles to tumour cells, for enhancing the uptake of liposomes by tumour cells, and for selected liposomal delivery of chemotherapeutic agents into tumour cells.
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主要参考文献


1: Huovinen M, Loikkanen J, Naarala J, Vähäkangas K. Toxicity of diuron in human cancer cells. Toxicol In Vitro. 2015 Oct;29(7):1577-86. doi: 10.1016/j.tiv.2015.06.013. Epub 2015 Jun 15. doi: 10.1556/ABiol.66.2015.1.5. doi: 10.1007/s11356-014-3523-2. Epub 2014 Sep 16. doi: 10.1016/j.scitotenv.2015.03.022. Epub 2015 Mar 13. doi: 10.1016/j.aquatox.2015.05.007. Epub 2015 May 14. doi: 10.1016/j.aquatox.2015.04.013. Epub 2015 Apr 13. doi: 10.1016/j.tox.2013.10.005. Epub 2013 Oct 27. doi: 10.1016/j.scitotenv.2014.09.052. Epub 2014 Oct 11. doi: 10.1007/s11356-013-1989-y. Epub 2013 Jul 20. doi: 10.1016/j.chemosphere.2016.02.073. Epub 2016 Mar 15. doi: 10.1016/j.scitotenv.2013.07.095. Epub 2013 Aug 25. doi: 10.1016/j.aquatox.2013.10.032. Epub 2013 Nov 7. doi: 10.1016/j.envpol.2015.11.054. Epub 2016 Feb 16. doi: 10.3109/10408444.2013.877870. Epub 2014 Feb 11. Review. doi: 10.1007/s00253-012-4318-3. Epub 2012 Aug 2. doi: 10.1002/ps.3490. Epub 2013 Mar 13. doi: 10.1016/j.marpolbul.2014.05.049. Epub 2014 Jun 13. doi: 10.1016/j.aquatox.2014.11.011. Epub 2014 Nov 24. doi: 10.1155/2013/251354. Epub 2013 Dec 31.
20: Dages C, Samouëlian A, Negro S, Storck V, Huttel O, Voltz M. Seepage patterns of Diuron in a ditch bed during a sequence of flood events. Sci Total Environ. 2015 Dec 15;537:120-8. doi: 10.1016/j.scitotenv.2015.07.130. Epub 2015 Aug 14.

合成参考文献


参考文献:10.1007/s00216-005-0167-6
摘要:Ibáñez M, Sancho JV, Pozo ÓJ, Hernández F. Use of liquid chromatography quadrupole time-of-flight mass spectrometry in the elucidation of transformation products and metabolites of pesticides. Diazinon as a case study. Analytical and Bioanalytical Chemistry. 2005 Dec 01;384(2):448–57. doi: 10.1007/s00216-005-0167-6.
参考文献:10.1186/1471-2156-12-62
摘要:Uddin MJ, Duy DN, Cinar MU, Tesfaye D, Tholen E, Juengst H, Looft C, Schellander K. Detection of quantitative trait loci affecting serum cholesterol, LDL, HDL, and triglyceride in pigs. BMC Genomic Data. 2011 Jul 13;12(1):62. doi: 10.1186/1471-2156-12-62.
参考文献:10.1007/s00894-011-1169-2
摘要:Singh DV, Adeppa K, Misra K. Mechanism of isoproturon resistance in Phalaris minor: in silico design, synthesis and testing of some novel herbicides for regaining sensitivity. Journal of Molecular Modeling. 2011 Jul 15;18(4):1431–45. doi: 10.1007/s00894-011-1169-2.
参考文献:10.1002/bdrb.20317
摘要:Grassi TF, Guerra MT, Perobelli JE, de Toledo FC, da Silva DS, De Grava Kempinas W, Barbisan LF. Assessment of female reproductive endpoints in Sprague-Dawley rats developmentally exposed to Diuron: potential ovary toxicity. Birth Defects Res B Dev Reprod Toxicol. 2011 Oct;92(5):478–86. doi: 10.1002/bdrb.20317.
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