CAS: 5900-13-0; 5-Bromo-3-Methoxypyrazin-2-Amine

相似化合物

446286-73-3 77112-66-4 1245649-92-6

上下游产品

CAS号124-41-4 甲醇钠 | CAS号24241-18-7 2-氨基-3,5-二溴吡嗪 | CAS号4774-10-1 2-氨基-3-甲氧基吡嗪 | CAS号87444-39-1 5-bromo-3-methy... | CAS号489431-66-5 2,5-二溴-3-甲氧基吡嗪 | CAS号67602-06-6 2-氨基-3-甲氧基-5-苯基吡嗪 | CAS号476622-89-6 5-溴-2-碘-3-甲氧基吡嗪

2-氨基-3-甲氧基吡嗪置于n-溴代丁二酰亚胺(Nbs)体系中,用 二氯甲烷 作为反应溶剂,化学反应 2.75H,反应生成 2-氨基-5-溴-3-甲氧基吡嗪
参考文献:Necrosulfonamide Inhibits Necroptosis By Selectively Targeting The Mixed Lineage Kinase Domain-Like Protein
标题:Necrosulfonamide Inhibits Necroptosis By Selectively Targeting The Mixed Lineage Kinase Domain-Like Protein
摘要:通过对20万种化合物进行高通量筛选和随后的结构活性关系(sar)研究,我们确定了硫酰胺(nsa)作为一种有效的小分子抑制剂,用于由tnf-A,Smac模拟剂和z-Vad-Fmk(t/s/z)组合诱导的坏死程序.
DOI:10.1039/c3Md00278K

专利信息

专利号:US-7772246-B2
优先权日:2007-08-01
标题:Pyrazole compounds as RAF inhibitors
发明人：CUI JINGRONG JEAN; DEAL JUDITH GAIL; GU DANLIN; GUO CHUANGXING; JOHNSON MARY CATHERINE; KANIA ROBERT STEVEN; KEPHART SUSAN ELIZABETH; LINTON MARIA ANGELICA; MCALPINE INDRAWAN JAMES; PAIRISH MASON ALAN; PALMER CYNTHIA LOUISE
权利人:PFIZER
摘要:The present invention is directed to compounds of Formula (I), n nand to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.

专利号:US-2012202787-A1
优先权日:2009-10-20
标 题:Novel Heteroaryl Imidazoles And Heteroaryl Triazoles As Gamma-Secretase Modulators
发明人：AM ENDE CHRISTOPHER WILLIAM; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN
权利人:AM ENDE CHRISTOPHER WILLIAM; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I; n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.