CAS: 625-51-4; N-(Hydroxymethyl)Acetamide

该化合物是具有氨化功能组特征的有机化合物,具有与乙酰胺结构氮相连的氢氧化甲基组(-CH2OH),在室内温度下,该化合物一般为白色至非白色固体,在水中可溶解,因为存在可形成氢联结的氢氧化亚甲基组.N-(Hydroxymothy)乙酰胺因其在各个领域的应用而著称,包括制药和生物化学,可以作为合成更复杂分子的中间体.其化学稳定性和再活性可受到环境中的pH影响,并可能参与氨化物的典型反应,例如水解或细胞化.安全数据表明,与许多氨化物一样,应谨慎处理该物质,因为它在与皮肤或眼睛接触时可能会引起刺激.

结构式图片

相似化合物

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CAS号60-35-5 乙酰胺 | CAS号50-00-0 甲醛 | CAS号32516-05-5 3,7-二乙酰基-1,3,5,... | CAS号556-50-3 双甘肽 | CAS号21163-79-1 N-formylacetamide | CAS号19647-70-2 S-(乙酰氨基甲基)-L-半胱氨酸 | CAS号79-16-3 N-甲基乙酰胺 | CAS号60-35-5 乙酰胺 | CAS号50-00-0 甲醛 | CAS号52574-08-0 3-(乙酰胺甲硫基)丙酸 | CAS号1066-51-9 氨甲基膦酸 | CAS号13831-32-8 acetamidomethyl... | CAS号13157-53-4 2-methyl-6-phen... | CAS号95501-85-2 N-(2-aminoethyl...

合成工艺路线路线简述

  • 合成目标产物 N-(Hydroxymethyl)Acetamide 主要起始原料 Glycylglycine
  • (文献来源)合成步骤主要原料 Glycylglycine
乙酰胺 反应生成 N-羟甲基乙酰胺
参考文献:Diaz,J.;Guegan,R.
标题:Diaz,J.;Guegan,R.

海关参考信息

专利信息


专利号:US-10280189-B2
优先权日:2012-07-17
标题:Method for the synthesis of aminoalkylenephosphonic acid
发明人:BURCK SEBASTIAN; LECLERCQ CEDRIC NICOLAS; NOTTE PATRICK
权利人:MONSANTO TECHNOLOGY LLC
摘要:A method for the synthesis of an aminoalkylenephosphonic acid or its phosphonate esters including the following steps: a) forming, in the presence of an aldehyde or ketone and an acid catalyst, a reaction mixture by mixing a compound having at least one HNR 1 R 2 moiety or a salt thereof, with a compound having one or more P—O—P anhydride moieties, the moieties having one P atom at the oxidation state (+III) and one P atom at the oxidation state (+III) or (+V), wherein the ratio of moles of aldehyde or ketone to N—H moieties is 1 or more and wherein the ratio of N—H moieties to P—O—P anhydride moieties is 0.3 or more, and b) recovering the resulting aminoalkylenephosphonic acid having compound or its phosphonate esters.

专利号:US-2004072738-A1
优先权日:2000-12-21
标 题 :Analogues of thiocoraline and be-22179
发明人:BOGER DALE L
摘要:A process for the total synthesis of thiocoraline and BE-22179 establishes the relative and absolute stereochemistry of these compounds and enables the construction and characterization of a series of related analogues. The mechanism for the bioactivity of thiocoraline, BE-22179 and their related analogues is charaterized. Thiocoraline, BE-22179, and their related analogues are disclosed to bind to DNA by high-affinity bisintercalation and are disclosed to exhibit exceptional cytotoxic activity.

专利号:US-7153703-B2
优先权日:2001-05-14
标 题 :Synthesis of stable colloidal nanocrystals using organic dendrons
发明人:PENG XIAOGANG; CHEN HAIYAN
权利人:UNIV ARKANSAS
摘要:A method for stabilizing colloidal suspensions of nanocrystals or nanoparticles in a solvent or solid matrix is provided by coating the nanocrystals with bulky organic molecules, specifically dendrons. By coating nanocrystals with a dense organic dendron coat and further cross-linking the dendron ligands, oxidation of the nanocrystals and dissociation of the ligands are avoided. This invention allows nanocrystals to undergo rigorous purification and processing. It may regularly be applied to a variety of nanocrystals.

专利号:US-3560521-A
优先权日:1967-08-07
标题:Blocking groups for cysteine containing peptides
发明人:MILKOWSKI JOHN D; VEBER DANIEL F; HIRSCHMANN RALPH F
权利人:MERCK & CO INC
摘要:NOVEL PROTECTING GROUPS FOR PEPTIDES CONTAINING A CRYSTEINE RESIDUE. PROCESS FOR THE SYNTHESIS OF PEPTIDES CONTAINING A CYSTEINE RESIDUE WHEREIN THE MERCAPTO FUNCTION OF THE CYSTEINE RESIDUE IS PROTECTED BY A LABILE BLOCKING GROUP. NOVEL INTERMEDIATES USEFUL IN PEPTIDE SYNTHESIS.

专利号:US-3770822-A
优先权日:1967-08-07
标 题 :S-lower alkanoyl- and acetonyl-amino-methylcysteine
发明人:MILKOWSKI J; VEBER D; HIRSCHMANN R
权利人:MERCK & CO INC
摘要:NOVEL PROTECTING GROUPS FOR PEPTIDES CONTAINING A CYTEINE RESIDUE. PROCESS FOR THE SYNTHESIS OF PEPTIDES CONTAINING A CYSTEINE RESIDUE WHEREIN THE MERCAPTO FUNCTION OF THE CYSTEINE RESIDUE IS PROTECTED BY A LABILE BLOCKING GROUP. NOVEL INTERMEDIATES USEFUL IN PEPTIDE SYNTHESIS.

专利号:US-4038306-A
优先权日:1967-08-07
标题 :N-t-butoxycarbonyl-s-lower alkanoylamidomethyl-cysteine and p-nitrophenyl esters
发明人:MILKOWSKI JOHN D; VEBER DANIEL F; HIRSCHMANN RALPH F
权利人:MERCK & CO INC
摘要:Novel protecting groups for peptides containing a cysteine residue. Process for the synthesis of peptides containing a cysteine residue wherein the mercapto function of the cysteine residue is protected by an acetamidomethyl radical or other labile blocking group. Novel intermediates useful in peptide synthesis.
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主要参考文献


1: Collins FWJ, O'Connor PM, O'Sullivan O, Rea MC, Hill C, Ross RP. Formicin - a novel broad-spectrum two-component lantibiotic produced by Bacillus paralicheniformis APC 1576. Microbiology (Reading). 2016 Sep;162(9):1662-1671. doi: 10.1099/mic.0.000340. Epub 2016 Jul 22. 26(18):3961-3965. doi: 10.1021/acs.orglett.4c01209. Epub 2024 Apr 28. 22(14):5337-5341. doi: 10.1021/acs.orglett.0c01584. Epub 2020 Jul 6.
29:91-8. Spanish. 13(3):135-40. Italian. 33(6):881-5. doi: 10.1128/AAC.33.6.881.

合成参考文献


摘要:Archiv der Pharmazie, 305(427), 1972 []
摘要:Cha, J. K., Science of Synthesis, (2005) 21, 374.
摘要:Lubell, W. D.; Blankenship, J. W.; Fridkin, G.; Kaul, R., Science of Synthesis, (2005) 21, 741.
摘要:Friestad, G. K., Science of Synthesis, (2009) 40, 100.
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