CAS: 63-05-8; Androst-4-Ene-3,17-Dione

上下游产品

CAS号1229-12-5 5β-雄烷-3,17-二酮 | CAS号58-22-0 睾酮 | CAS号152-58-9 可托多松 | CAS号897-06-3 1,4-雄烯二酮 | CAS号57-83-0 孕酮； 黄体素； 黄体酮 | CAS号53-43-0 去氢表雄酮 | CAS号106065-57-0 3,3,17,17-Bis-a... | CAS号571-36-8 5-雄烯二酮 | CAS号382-44-5 4-雄烯-11β-醇-3,17-二酮 | CAS号4075-20-1 14alpha,17beta-... | CAS号24704-84-5 (6S,8R,9S,10R,1... | CAS号564-33-0 11α-羟基雄烯二酮 | CAS号510-64-5 19-羟基雄甾-4-烯-3,17-二酮 | CAS号968-49-0 19-氧雄烯二酮 | CAS号53-16-7 雌酚酮 | CAS号14935-81-0 5-雄甾-3-烯-17-酮

睾酮置于氧气,Langlois Reagent体系中,用 乙腈 作为反应溶剂,25.0 °C,101.33 Kpa 条件下,反应 12.0H,以82%的收率获得产物雄烯二酮
参考文献:三氟甲烷亚磺酸钠介导的酒精的有氧氧化光催化策略.
标题:三氟甲烷亚磺酸钠介导的酒精的有氧氧化光催化策略.
摘要:首次开发了三氟甲烷亚磺酸钠介导的酒精好氧氧化的光催化策略,仲醇和伯醇的光氧化还原好氧氧化分别以高至优异的产率提供了相应的酮和羧酸.
DOI:10.1039/d0Cc05799A

专利信息

专利号:US-11479577-B2
优先权日:2016-05-18
标题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY; DAVIES IEUAN; OTTER CARL; BATCHELOR RHYS
权利人:NZP UK LTD
摘要:The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I):wherein:, R1, R2, R3, R4, R5, R6 and Y are as defined herein.The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

专利号:WO-2009034398-A1
优先权日:2007-09-11
标题:Process for the synthesis of 6-hydroxymethyl-l,4- androstadien-3.17-dione
发明人：HANTOS GABOR; HERINE BERTA MONIKA; TEGDES ANIKO; BARTHO ISTVAN; DEVENYI TAMAS; GALIK GYOERGY; PECSNE RAZSO AGNES; GANCSOS VALERIA; KOENCZOEL KALMAN; MAHO SANDOR
权利人:RICHTER GEDEON NYRT; HANTOS GABOR; HERINE BERTA MONIKA; TEGDES ANIKO; BARTHO ISTVAN; DEVENYI TAMAS; GALIK GYOERGY; PECSNE RAZSO AGNES; GANCSOS VALERIA; KOENCZOEL KALMAN; MAHO SANDOR
摘要:The invention relates to a novel process for the synthesis of 6-hydroxymethyl-l,4- androstadien-3,17-dione which means dehydrogenating 6-hydroxymethyl-4-androsten- 3,17-dione in the presence of a biocatalyst.

专利号:US-2008146656-A1
优先权日:2005-06-01
标题:Use of a steroid sulphatase inhibitor for inhibiting the synthesis of androstenedione and/or testosterone
发明人：REED MICHAEL JOHN; PUROHIT ATUL; WOO LOK WAI LAWRENCE; POTTER BARRY VICTOR LLOYD
权利人:REED MICHAEL JOHN; PUROHIT ATUL; WOO LOK WAI LAWRENCE; POTTER BARRY VICTOR LLOYD
摘要:There is provided use of a compound capable of inhibiting a steroid sulphatase enzyme (E.C.3.1.6.2) in the manufacture of a medicament for inhibiting in vivo synthesis of at least one of androstenedione and testosterone, which may be useful for the treatment of hirsutism, excess sebum production, benign breast disease, benign ovarian disease, polycystic ovarian disease and female infertility among others.

专利号:US-4219489-A
优先权日:1978-09-05
标题:Synthesis of steroids
发明人：BUNES LEONARD A; JOHNSON WILLIAM S
权利人:STANFORD LELAND JUNIOR UNIV TR
摘要:Method and compounds are provided for use in the synthesis of steroids wherein a polyolefin is provided having an initiating group having a chalcogen atom in juxtaposition to a double bond, so as to be capable of bond formation to close to form a ring and having a terminating group involving pi unsaturation (a double or triple bond) conjugated to an aromatic ring. Upon acid catalysis, sigma bonds are formed through the interaction of a carbocation formed at the carbon atom bonded to the chalcogen atom and the double bond intermediate the initiating group and the terminating group, which close to form rings of a steroid nucleus, the carbocation interacting with the pi unsaturation conjugated with the aromatic group and being captured by a nucleophile present in the acidic reaction medium. The resulting steroid product may then be modified in known ways to produce known steroids.

专利号:US-8367394-B2
优先权日:2007-07-04
标题:Process for the synthesis of 9α-hydroxy-steroids
发明人：OLASZ KATALIN; TEGDES ANIKO; GANCSOS VALERIA; HANTOS GABOR; KOENCZOEL KALMAN; BALOGH GABOR; ERDELYI SANDOR
权利人:RICHTER GEDEON NYRT; OLASZ KATALIN; TEGDES ANIKO; GANCSOS VALERIA; HANTOS GABOR; KOENCZOEL KALMAN; BALOGH GABOR; ERDELYI SANDOR
摘要:The present invention relates to a novel selective synthesis of 9α-hydroxy-steroid derivatives of the general formula (I) (I)—wherein the meaning of -A-A′- is —CH 2 —CH 2 — or —CHâ•?CH— group—by the bioconversion of compounds of the general formula (II) (II) wherein the meaning of -A-A′- is —CH 2 —CH 2 — or —CHâ•?CH— group—by using Nocardia farcinica bacterium strain, deposition number of which is NCAIM (P)—B 001342, as hydroxylating microorganism in the bioconversion.

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.