专利号:US-11702380-B2 优先权日:2021-03-10 标 题:Synthesis of omecamtiv mecarbil 发明人:CAILLE SEBASTIEN; MURRAY JAMES; QUASDORF KYLE; NGUYEN HANNAH; SILVA ELIPE MARIA VICTORIA; ERICSON ARI ELIZABETH 权利人:AMGEN INC 摘要:Provided herein are synthetic methods for the preparation of intermediates that are utilized in the synthesis of omecamtiv mecarbil dihydrochloride.
专利号:US-6987186-B2 优先权日:2003-01-28 标 题 :Synthesis of small particle size quinacridone of beta crystal phase 发明人:COLE DAMIEN THURBER; JEGANATHAN SURULIAPPA GOWDER; HE YINGXIA 权利人:CIBA SC HOLDING AG 摘要:The present invention relates to a process for the synthesis of beta-quinacridone by oxidation in the presence of selected additives that promote the formation of the desired crystal phase and particle size.
专利号:US-12269811-B2 优先权日:2017-06-30 标 题:Synthesis of omecamtiv mecarbil 发明人:CAILLE SEBASTIEN; QUASDORF KYLE; ROOSEN PHILIPP C; SHI XIANQING; COSBIE ANDREW; WANG FANG; WU ZUFAN; NEERGUNDA ARCHANA; QUAN BIN PETER; GUAN LIANXIU 权利人:AMGEN INC 摘要:Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates. (1)
专利号:US-2009318592-A1 优先权日:2005-10-11 标 题 :Process for the Synthesis of Amine Ethers 发明人:FREY MARKUS; BROENNIMANN VALERIE 权利人:CIBA GEIGY CORP 摘要:The present invention relates to novel processes for the preparation of a sterically hindered amine ether by reacting a corresponding sterically hindered amine oxide with a ketone or an aldehyde with at least one reactive H in the presence of a peroxydisulphate. Products obtained by this process may be hydrogenated. The compounds made by these processes are particularly effective in the stabilization of polymer compositions against harmful effects of light, oxygen and/or heat and as flame-retardants for polymers.
专利号:US-2007191516-A1 优先权日:2004-03-15 标题 :Process for the synthesis of amine ethers 发明人:FREY MARKUS; RAST VALERIE; BRAIG ADALBERT; KRAMER ANDREAS 权利人:FREY MARKUS; RAST VALERIE; BRAIG ADALBERT; KRAMER ANDREAS 摘要:A process for the preparation of a sterically hindered amine ether which comprises reacting a corresponding sterically hindered aminoxide with a C 5 -C 18 alk-1-ene in the presence of an organic hydroperoxide and optionally hydrogenating the resulting product as well as the product mixtures obtained therewith and their use as stabilizers and flame retardants.
专利号:US-7402675-B2 优先权日:2000-05-26 标题 :Process for the synthesis of amine ethers from secondary amino oxides 发明人:HAFNER ANDREAS; KIRNER HANS JUERG; SCHWARZENBACH FRANZ; VAN DER SCHAAF PAUL ADRIAAN; NESVADBA PETER 权利人:CIBA SC HOLDING AG 摘要:An amine ether of formula A n nwherein a is 1 or 2; and when a is 1, E is E′; when a is 2, E is L;n E′ is C 1 -C 36 alkyl; C 3 -C 18 alkenyl; C 2 -C 18 alkinyl; C 5 -C 18 cycloalkyl; C 5 -C 18 cycloalkenyl; a radical of a saturated or unsaturated aliphatic bicyclic or tricyclic hydrocarbon of 7 to 12 carbon atoms; C 2 -C 7 alkyl or C 3 -C 7 alkenyl substituted by halogen; C 7 -C 15 aralkyl or C 7 -C 15 aralkyl substituted by C 1 -C 4 alkyl or phenyl; or E′ is a radical of formula (VII) as explained in claim 1; T′ is tertiary C 4 -C 18 alkyl or phenyl, each of which are unsubstituted or substituted by halogen, OH, COOR 21 or C(O)—R 22 ; or T′ is C 5 -C 12 cycloalkyl; C 5 -C 12 cycloalkyl which is interrupted by at least one O or —NR 18 —; a polycyclic alkyl radical having 7-18 carbon atoms, or the same radical which is interrupted by at least one O or —NR 18 —; or T′ is —C(G 1 )(G 2 )-T″; or C 1 -C 18 alkyl or C 5 -C 12 cycloalkyl substituted by n n n n n n n n n n n n T″ is hydrogen, halogen, NO 2 , cyano, or is a monovalent organic radical comprising 1-50 carbon atoms; n or T″ and T′ together form a divalent organic linking group completing, together with the hindered amine nitrogen atom and the quaternary carbon atom substituted by G 1 and G 2 , an optionally substituted five- or six-membered ring structure; and all other residues are as defined in claim 1, n are obtained in good yield from the corresponding N-oxyl hindered amine precursor by reaction with a hydrocarbon E 1 -H or H-L-H in the presence of an organic hydroperoxide and a catalytic amount of copper or a copper compound. n n n n n The products of present process find utility as polymerization regulators and/or light stabilizers for organic material.
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