合成目标产物 Dibutyl Sebacate 主要起始原料 Sebacic Acid And 1-Butanol
(文献来源)合成步骤主要原料 Sebacic Acid 和 1-Butanol
邻苯二甲酸二丁酯 以 乙醇 用作溶剂,化学反应生成癸二酸二丁酯 参考文献:Process For Producing Resin Composition And Process For Producing Molded Article 标题:Process For Producing Resin Composition And Process For Producing Molded Article 摘要:一种医用树脂组合物的制备方法是将具有酯基重复单元的聚合物(a)的粉末和含有6个或更多碳原子的乙烯酸酯单体(b)的液体混合以增加粘度,根据需要进一步进行聚合反应.因此,所制备的树脂组合物抑制了刺激性物质的渗出,减少了内分泌干扰物对人体的不良影响等,并且可以高效制备.该树脂组合物适用于牙科树脂组合物,如组织调节剂,功能性印模材料,衬里材料,假牙基材料或口腔器材材料.
专利号:US-2024082118-A1 优先权日:2021-05-19 标 题:Topical compositions and methods of preparing the same 发明人:ABRAMOVICH SAGI; AVIDOR GAL; LANDA BENZION 权利人:LANDA LABS 2012 LTD 摘要:There is disclosed a composition comprising a water-insoluble thermoplastic compound capable of stimulating collagen synthesis (CSSC), the CSSC having a molecular weight of more than 0.6 kDa and being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less and a viscosity of 107 mPa·s or less. The nano-elements of CSSC can be capable of stimulating the synthesis of skin proteins and/or enabling the delivery of active agents upon their application to a surface to be treated therewith. Methods for preparing the compositions and uses thereof are also provided.
专利号:US-8846916-B2 优先权日:2009-05-11 标题:Sitagliptin synthesis 发明人:GORE VINAYAK GOVIND; GADAKAR MAHESHKUMAR; BHOSLE PRIYANKA; SHINDE SURESH 权利人:GORE VINAYAK GOVIND; GADAKAR MAHESHKUMAR; BHOSLE PRIYANKA; SHINDE SURESH; GENERICS UK LTD 摘要:The present invention relates to novel processes for the preparation of enantiomerically enriched β-amino acid derivatives such as β-amino esters useful for the synthesis of enantiomerically enriched biologically active molecules such as sitagliptin. The key step involves the resolution of the racemate with mandelic acid.
专利号:US-9577149-B2 优先权日:2011-12-01 标 题:Continuous synthesis of high quantum yield InP/ZnS nanocrystals 发明人:LU HUACHANG; HOHEISEL WERNER; MLECZKO LESLAW; NOWAK STEPHAN 权利人:QUANTUM MAT CORP 摘要:The invention relates to a continuous-flow synthesis process for the preparation of high quality indium phosphide/zinc sulfide core/shell semiconduting nanocrystals in particular quantum dots (QD) conducted in a micro-reaction system comprising at least one mixing chamber connected to one reaction chamber.
专利号:US-2023114753-A1 优先权日:2020-03-06 标 题 :Use of a group of markers for diagnosing and adjusting treatment of primary biliary cholangitis, pharmaceutical composition and solid dosage form for treating primary biliary cholangitis 发明人:JAIN NITIN 权利人:MILI HEALTHCARE TRADE DMCC LLC 摘要:A method of diagnosis and treatment of primary biliary cholangitis is provided. Additionally, a pharmaceutical composition and a solid dosage form for the treatment of primary biliary cholangitis, containing ursodeoxycholic and obeticholic acids, are provided. The technical contribution resides in obtaining a new all-purpose pharmaceutical composition and solid dosage form for the treatment of PBC, which includes both ursodeoxycholic and obeticholic acids, which is effective in use at all stages of PBC and has a complex mechanism of action. In particular, simultaneous blockage of the transport and synthesis of bile acids is achieved.
专利号:US-5905091-A 优先权日:1996-07-03 标 题 :Enhancement of skin pigmentation by prostaglandins 发明人:FULLER BRYAN B 权利人:UNIV OKLAHOMA 摘要:A composition comprising a carrier and prostaglandin effective in stimulating synthesis of melanin in a human melanocyte thereby enhancing pigmentation of the human skin and optionally comprising a lysosomotropic agent, a phosphodiesterase inhibitor, and/or methylxanthines, and a method of use of the composition. Use of this composition promotes tanning of the human skin and increases photoprotection from ultraviolet radiation.
专利号:WO-2010146391-A1 优先权日:2009-06-15 标题:Regioselective synthesis of letrozole 发明人:GORE VINAYAK GOVIND; SHUKLA VINAY KUMAR; BHANDARI SHERYAS; HASBE SURESH; MEKDE SANDEEP 权利人:GENERICS UK LTD; MYLAN INDIA PRIVATE LTD; GORE VINAYAK GOVIND; SHUKLA VINAY KUMAR; BHANDARI SHERYAS; HASBE SURESH; MEKDE SANDEEP 摘要:The present invention relates to an improved process for the preparation of letrozole (I) and its pharmaceutically acceptable salts, to compositions comprising letrozole or a pharmaceutically acceptable salt thereof, and to uses of such compositions. In particular it relates to a process and to novel intermediates for preparing letrozole and its salts substantially free from regioisomeric impurities.
[参考文献]: Effect Of Substitution Of Plasticizer Dibutyl Phthalate With Dibutyl Sebacate On Eudragit® Rs30D Drug Release Rate Control. [参考文献]: A-K Vynckier, Et Al. Calendering As A Direct Shaping Tool For The Continuous Production Of Fixed-Dose Combination Products Via Co-Extrusion. Eur J Pharm Biopharm. 2015 Oct:96:125-31. [参考文献]: B C Lippold, Et Al. Drug Release From Diffusion Pellets Coated With The Aqueous Ethyl Cellulose Dispersion Aquacoat Ecd-30 And 20% Dibutyl Sebacate As Plasticizer: Partition Mechanism And Pore Diffusion. Eur J Pharm Biopharm. 1999 Jan;47(1):27-32. [参考文献]: Kit Frederiksen, Et Al. Formulation Considerations In The Design Of Topical, Polymeric Film-Forming Systems For Sustained Drug Delivery To The Skin. Eur J Pharm Biopharm. 2015 Apr:91:9-15. [参考文献]: Luís G Dias, Et Al. A Novel Approach For Honey Pollen Profile Assessment Using An Electronic Tongue And Chemometric Tools. Anal Chim Acta. 2015 Nov 5:900:36-45.
合成参考文献
参考文献:10.2147/ijn.s19151 摘要:Rao S, Song Y, Peddie F, Evans AM. Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs. Int J Nanomedicine. 2011;6():1245–51.