CAS: 110-12-3; 5-Methyl-2-Hexanone

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CAS号627-59-8 5-甲基-2-己醇 | CAS号73503-97-6 trimethyl(5-met... | CAS号78-84-2 异丁醛 | CAS号67-64-1 丙酮 | CAS号108-86-1 溴苯 | CAS号1522-34-5 2-异丁基乙酰乙酸乙酯 | CAS号67-56-1 甲醇 | CAS号75-30-9 2-碘代丙烷 | CAS号78-94-4 丁烯酮 | CAS号110792-88-6 2-hydroxy-2,5-d... | CAS号3730-60-7 2,5-二甲基-2-己醇 | CAS号503-74-2 异戊酸 | CAS号64-19-7 冰醋酸 | CAS号28292-43-5 1,4-二甲基戊胺盐酸盐 | CAS号627-59-8 5-甲基-2-己醇 | CAS号592-13-2 2,5-二甲基己烷 | CAS号591-76-4 2-甲基已烷(异庚烷) | CAS号646-07-1 4-甲基戊酸 | CAS号104214-14-4 methyl 6-methyl...

5-甲基-2-己酮肟置于盐酸,Sodium Chlorite体系中,用 水 用作溶剂,化学反应 0.08H,以92%的收率获得5-甲基-2-己酮
参考文献:A Rapid,Efficient Method For Deprotection Of Oximes To Carbonyl Compounds With Naclo_{2<> In Water
标题:A Rapid,Efficient Method For Deprotection Of Oximes To Carbonyl Compounds With Naclo2<> In Water
摘要:一种利用水中的次氯酸钠(naclo2)对肟进行快速,高效的脱保护以得到羰基化合物的方法已被展示.该方案已被发现适用于广泛的醛肟和酮肟,且能够以非常好至优秀的收率获得相应的羰基化合物.
Doi:10.2174/157017861201150112125024}

专利信息

专利号:WO-2009135600-A1
优先权日:2008-05-07
标题:Catalysts for the synthesis of polyurethanes
发明人：LINDNER STEFAN; BAHNMUELLER STEFAN; SCHMIDT AXEL; WEIKARD JAN; BUCHMEISER MICHAEL; BANTU BHASKER; FRIEDERICHS WOLFGANG; KRAUSE JENS; REITER STEPHAN
权利人:BAYER MATERIALSCIENCE AG; LINDNER STEFAN; BAHNMUELLER STEFAN; SCHMIDT AXEL; WEIKARD JAN; BUCHMEISER MICHAEL; BANTU BHASKER; FRIEDERICHS WOLFGANG; KRAUSE JENS; REITER STEPHAN
摘要:The invention relates to novel catalysts for the synthesis of polyurethanes, represented by general formula (I) or (II), or compounds obtained by reacting a metal salt of the metals magnesium, calcium, yttrium, lanthanum, titanium, zirconium, manganese, iron, cobalt, zinc, aluminium, tin, comprising an anion from the group fluoride, chloride, bromide, sulphonate, trifluoromethanesulphonate, methanesulphonate, benzolsulphonate, para-toluenesulphonate, carboxy-C1-C10-alkyl, carboxy-C3-C10-cycloalkyl, carboxy- C2-C10-alkenyl, C1-C10-alkoxy, acetylacetonate, trifluoroacetlyacetonate or hexafluoroacetylacetonate, with N-heterocyclic compounds of general structure I; or with N-heterocyclic compounds of general structure II; or with N-heterocyclic compounds of general structure III.

专利号:US-10905769-B2
优先权日:2015-11-13
标 题:Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE JR TERRENCE R; HYMEL DAVID T; TSUJI KOHEI
权利人:THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:The description provides novel compounds that may serve as anticancer therapeutics. The compounds of the description bind to polo-like kinases through the polo-box domain. The peptide derivatives of the description have achieved improved efficacy in biochemical assays against Plk1. Exemplary compounds of the description include macrocyclic peptidomimetics with high affinity and selectivity for polo-like kinases, which may provide the basis for a new genre of anticancer therapeutics. Other exemplary compounds of the description include bi-valent compounds with that bind to polo-like kinases through both kinase domain and polo-box domain simultaneously by incorporating additional moieties that target Plk1 kinase domain, which significantly enhances affinitity relative and may provide the basis for a new genre of anticancer therapeutics. The description also provides methods of use, methods of preparation, compositions, and kits thereof. Further, the description provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.

专利号:WO-2025073833-A1
优先权日:2023-10-04
标 题:Optimized process for the preparation of iopamidol
发明人：BUONSANTI FEDERICA; MAZZON ROBERTA; FRETTA ROBERTA
权利人:BRACCO IMAGING SPA
摘要:The present invention relates to the field of organic chemistry, in particular to the synthesis of iodinated contrast agents. More in particular, the invention relates to a sustainable process for the synthesis of iopamidol which allows to improve the purity profile of the product and avoids the use of potentially hazardous reagents and solvents.

专利号:US-7820858-B2
优先权日:2006-03-25
标 题 :Concise β2-amino acid synthesis via organocatalytic aminomethylation
发明人：CHI YONGGUI; GELLMAN SAMUEL H; POMERANTZ WILLIAM C; HORNE WILLIAM S; GUO LI; ENGLISH EMILY P
权利人:WISCONSIN ALUMNI RES FOUND
摘要:The present invention provides a method for the synthesis of β 2 -amino acids. The method also provides methods yielding α-substituted β-amino aldehydes and β-substituted γ-amino alcohols. The present method according to this invention allows for increased yield and easier purification using minimal chromatography or crystallization. The methods described herein are based on an aldehyde aminomethylation which involves a Mannich reaction between an aldehyde and a formaldehyde-derived N,O-acetal (iminium precursor) and a catalyst, such as, for example, L-proline or a pyrrolidine. The invention allows for large scale, commercial preparation of β 2 -amino acids.

专利号:US-2023212216-A1
优先权日:2019-12-20
标 题:Synthesis of lactone derivatives and their use in the modification of proteins
发明人：MORRIS ALEXANDER REDFERN; SUTOV GRIGORIJ; BRUNE KARL DIETRICH
权利人:GENIE BIOTECH UK LTD
摘要:Site-specific modifications of proteins are desirable in biotechnological applications such as biopharmaceuticals, immunotherapy, vaccines, and are useful in chemical biology. Gluconoylation is a non-enzymatic, covalent, post-translational modification commonly observed on N-terminal His-Tags bearing proteins. We synthesized glucono-1,5-lactone derivatives, including azido variants for selective acylation. High yield acylation is achieved by simply mixing derivatives with target protein amidst diverse conditions of temperatures, aqueous buffers, excipients, or complex cell lysate.

专利号:WO-2025056767-A1
优先权日:2023-09-15
标题 :Process for the preparation of enantiomerically enriched aliphatic amines
发明人：BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
权利人:SYNGENTA CROP PROTECTION AG
摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.