CAS: 19869-42-2; 1-Methylazepan-4-One Hydrochloride

相似化合物

188975-88-4 83621-33-4 1208-75-9

氮杂环庚烷-2,5-二酮置于potassium Carbonate,对甲苯磺酸体系中,用 甲苯 用作溶剂,化学反应 32.0H,反应生成1-甲基六氢氮杂卓-4-酮盐酸盐
参考文献:一种制备n-甲基氮卓-4-酮盐酸盐的方法
标题:一种制备n-甲基氮卓-4-酮盐酸盐的方法
摘要:本发明公开一种制备n‑甲基氮卓‑4‑酮盐酸盐的方法.该方法以4‑肟环已酮为原料,在beckmann重排条件下得到氮杂环庚烷‑2,5‑二酮,接着与乙二醇缩合生成缩酮,经红铝还原酰胺,再甲基化,在盐酸条件下脱掉乙二醇最终得到n‑甲基氮卓‑4‑酮盐酸盐.本发明提供一种安全可靠高效的合成途径,原料价格便宜,反应条件温和,不需要使用易爆的重氮甲烷,也不需要丙烯酸甲酯这种易聚合且高致癌的化学试剂,本方法更适合工业大规模生产.

专利信息

专利号:US-5760221-A
优先权日:1993-12-18
标 题:Method for the preparation of hexahydroazepinones and hexahydroazepinoles
发明人：OLBRICH ALFRED; ENGEL JUERGEN; KUTSCHER BERNHARD; MOELLER ROLAND
权利人:ASTA MEDICA AG
摘要:This disclosure describes two technical procedures for the high-yield synthesis of heterocyclic seven-membered ring-systems by Dieckmann-condensation avoiding usual dilution techniques and long reaction times. Thus, it significantly increases the overall yields of the pharmaceutically active ingredients azelastine and flezelastine, whose synthesis, starting from these seven-membered heterocyclic rings, is reported elsewhere. Yields range from 80-89%, avoiding waste and increasing economics of the synthesis.

专利号:CN-114507184-B
优先权日:2020-11-17
标题:Synthesis method and application of 1-methylhexahydroazepine-4-one hydrochloride