CAS: 2058-58-4; (R)-2,4-Diamino-4-Oxobutanoic Acid

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5794-24-1 3130-87-8 70-47-3

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CAS号3130-87-8 DL-天冬酰胺,一水合物 | CAS号108-31-6 顺酐 | CAS号70-47-3 L-天冬酰胺 | CAS号101-41-7 苯乙酸甲酯 | CAS号4474-86-6 Na-苄氧羰基-D-天冬酰胺 | CAS号21860-86-6 2-amino-4-ethox... | CAS号7664-41-7 氨 | CAS号43101-48-0 Diethyl aspartate | CAS号7732-18-5 水 | CAS号4474-86-6 Na-苄氧羰基-D-天冬酰胺 | CAS号70-47-3 L-天冬酰胺 | CAS号636-61-3 D-(+)-苹果酸 | CAS号33239-40-6 2-oxosuccinamic acid | CAS号617-45-8 DL-天门冬氨酸 | CAS号1783-96-6 D-天门冬氨酸 | CAS号92142-18-2 甲苯磺酰基-D-天冬酰胺

L-天冬酰胺置于水体系中,化学反应生成D-天冬酰胺
参考文献:Ravenna; Bosinelli,Gazzetta Chimica Italiana,1919,Vol. 49 Ii,P. 315
标题:Ravenna; Bosinelli,Gazzetta Chimica Italiana,1919,Vol. 49 Ii,P. 315

专利信息

专利号:US-12421534-B2
优先权日:2021-11-10
标 题 :Engineered enzymes and method for the synthesis of diverse tyrosine analogs
发明人：ALMHJELL PATRICK J; ARNOLD FRANCES H
权利人:CALIFORNIA INST OF TECHN
摘要:Provided herein is an engineered tryptophan synthase β-subunit (TrpB) that catalyzes the synthesis of tyrosine, tyrosine analogs, or salts thereof. Also provided herein are methods for preparing tyrosine, tyrosine analogs, or a salt thereof using the engineered TrpB described herein.

专利号:US-12024731-B2
优先权日:2017-05-03
标 题 :Methods and enzyme catalysts for the synthesis of non-canonical amino acids
发明人：BOVILLE CHRISTINA E; BRINKMANN-CHEN SABINE; BULLER ANDREW R; ROMNEY DAVID K; PRIER CHRISTOPHER K; KOCH PHILIPP; SCHEELE REMKES A
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure provides methods for preparing β-substituted tryptophan compounds. The methods include: combining i) an unsubstituted indole or a substituted indole, ii) a β-substituted serine, and iii) a tryptophan synthase β-subunit (i.e., a TrpB); and maintaining the resulting mixture under conditions sufficient to form the β-substituted tryptophan. The TrpB contains at least one amino acid mutation which promotes formation of an amino-acrylate intermediate. New TrpB variants and new β-substituted tryptophan analogs are also described.

专利号:US-10829792-B2
优先权日:2017-03-21
标 题 :Biocatalytic synthesis of strained carbocycles
发明人：CHEN KAI; HUANG XIONGYI; KAN S B JENNIFER
权利人:CALIFORNIA INST OF TECHN
摘要:Provided herein are methods for producing products containing strained carbocycles, such as cyclopropene moieties and/or bicyclobutane moieties. The methods include combining an alkyne and a carbene precursor in the presence of a heme protein, e.g., a cytochrome P450, under conditions sufficient to form the strained carbocycle. Reaction mixtures for producing strained carbocycles are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming cyclopropenes, bicyclobutanes, and related products.

专利号:WO-9717367-A1
优先权日:1995-11-03
标 题 :Method of grf peptides synthesis
发明人：IBEA MICHEL; BRAZEAU PAUL
权利人:THERATECHNOLOGIES INC
摘要:The present invention relates to a high yield manufacturing process of (Gly or Ala)?15 or 32¿ GRF containing peptide, resulting in GRF peptides synthesis at a yield averaging 65 to 68 %. The method comprises the steps of: a) synthesis of a 14 to 15 residues of the fully protected GRF peptide acidic segments (S¿1?)-OH and (S2)-OH from sasrin resin, using sequential Fmoc chemistry; b) synthesis of a 12 to 15 residues of the side chain protected GRF peptide amide segments (S3)-NH-, (S4)-NH-, and/or (S5)-NH- on solid phase using any TFA sensitive resin; and c) one or two coupling steps of the synthesized GRF peptide segments of steps a) and b) on solid phase.

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-2024409571-A1
优先权日:2023-06-08
标 题:Chemoenzymatic synthesis of n-acetylated gangliosides and glycosphingosines
发明人：CHEN XI; YU HAI; MISHRA BIJOYANANDA; ZHENG ZIMIN; AGRAHARI ANAND KUMAR; GUCCHAIT ARIN
权利人:UNIV CALIFORNIA
摘要:Described herein are novel stable 9-N-, 8-N-, and 7-N-acetyl analogues of instable 9-O-acetyl, 8-O-acetyl, and 7-O-acetyl b-series gangliosides and glycosphingosines, including GD3, GD2, GD1b, GT1b, GQ1b, and their glycosphingosines. Chemoenzymatic methods for the production of the stable 9-N-, 8-N-, and 7-N-acetyl analogues are also described herein.