3,3-二甲基-1-丁酸置于氯化亚砜体系中,化学反应生成 叔丁基乙酸乙酯 参考文献:Preparation Of Tert-Butylacetic Acid And Its Derivatives 标题:Preparation Of Tert-Butylacetic Acid And Its Derivatives 摘要: DOI:10.1021/ja01337A055
专利号:US-8455479-B2 优先权日:2008-01-24 标 题 :Heterocyclic compounds 发明人:JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; SINGH NISHAN; NANDA GURMEET KAUR; MAGADI SITARAM KUMAR; SHARMA SUDHIR KUMAR 权利人:JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; SINGH NISHAN; NANDA GURMEET KAUR; MAGADI SITARAM KUMAR; SHARMA SUDHIR KUMAR; PANACEA BIOTEC LTD 摘要:The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers including R and S isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising compounds of Formula I and methods of treating or preventing one or more conditions that may be regulated or normalized via inhibition of dipeptidyl peptidase IV (DPP-IV).
专利号:US-5936132-A 优先权日:1994-03-11 标题 :Alkene intermediates and synthesis thereof 发明人:MATSUMOTO MASAKATSU 摘要:A chemiluminescent 1,2-dioxetane derivative having a formula (I): ##STR1## wherein R 1 and R 4 each represent, individually, hydrogen, an alkyl group, an alkoxyl group, a hydroxyl group, or --OS;(R 9 R 10 R 11 ) in which R 9 , R 10 and R 11 each represent an alkyl group; R 2 , R 3 , R 5 and R 6 each represent, individually, hydrogen or an alkyl group, provided that R 2 , R 3 , R 5 and R 6 each cannot be hydrogen at the same time, and that R 2 and R 3 , and R 5 and R 6 , each taken together, can form a cycloalkyl group; R 7 represents an alkyl group; R 8 represents hydrogen, an alkoxyl group, a phosphate salt group, or --OSi(R 9 R 10 R 11 ); intermediates for synthesizing the above 1,2-dioxetane derivative; and methods of producing the intermediates are provided.
专利号:US-9650341-B2 优先权日:2010-05-04 标 题 :Process for synthesizing oxidized lactam compounds 发明人:REMENAR JULIUS F; BLUMBERG LAURA COOK; ZEIDAN TAREK A 权利人:ALKERMES PHARMA IRELAND LTD 摘要:The invention provides a method for the synthesis of dehydrogenated lactam drugs of Formula I:
专利号:US-7825149-B2 优先权日:2006-01-19 标 题 :Substituted imidazoles 发明人:CHUBB NATHAN ANTHONY LOGAN; COX MARK ROGER; DAUVERGNE JEROME SEBASTIEN; EWIN RICHARD ANDREW; LAURET CHRISTELLE 权利人:PFIZER LTD 摘要:This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.