CAS: 56542-67-7; 3-Cyanobenzene-1-Sulfonylchloride

该化合物是一种有机化合物,其特征是附于一个氰化苯环的全氟辛烷磺酸功能组;其特征是增强反应力的磺酰基(SO2Cl),使其在各种化学合成应用中有用,特别是在形成磺酰胺和其他衍生物时有用;该化合物一般没有颜色,可粉黄的黄色液体或固体,取决于其纯度和形态;以其强的电益性而著称,它能够随时与核素发生反应;此外,该化合物对水分具有敏感性,应谨慎处理,因为它在水解时会释放有毒气体;该化合物在制药业和农用化学品合成中使用,突出其在有机化学中的重要性;在与该物质打交道时,适当的安全防范措施,包括使用个人防护设备,由于其腐蚀性,对于使用该物质至关重要.

结构式图片

欧盟法规

ECHA物质C&L通报

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CAS号2237-30-1 3-氨基苯甲腈 | CAS号636-76-0 间羧基苯磺酰胺 | CAS号4025-64-3 间氯磺酰基苯甲酸 | CAS号10026-13-8 五氯化磷 | CAS号3118-68-1 间氰基苯磺酰胺 | CAS号930703-10-9 3-(吗啉-4-磺酰基)苯甲腈 | CAS号56542-62-2 3-Cyano-N-methy... | CAS号56542-63-3 3-氰基-n-丙基苯磺酰胺 | CAS号597561-38-1 3-氰基-N,N-二甲基苯磺酰胺

合成工艺路线路线简述

    间羧基苯磺酰胺置于五氯化磷体系中,化学反应生成 3-氰基苯磺酰氯
    参考文献:Delaby; Harispe; Paris,Bulletin De La Societe Chimique De France,1945,Vol. <5>12,P. 954,960
    标题:Delaby; Harispe; Paris,Bulletin De La Societe Chimique De France,1945,Vol. <5>12,P. 954,960

    海关参考信息

    专利信息


    专利号:CN-117720498-A
    优先权日:2023-11-03
    标 题 :Synthesis of a new coumarin derivative containing a sulfonamide fragment and preparation method and application of its composition

    专利号:US-8163773-B2
    优先权日:2005-07-11
    标题 :Organic compounds
    发明人:BREITENSTEIN WERNER; ERHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; MASUYA KEIICHI; KONISHI KAZUHIDE; YOKOKAWA FUMIAKI; KANAZAWA TAKANORI; JACOBY EDGAR; MARZINZIK ANDREAS; GROSCHE PHILIPP; KAWAKAMI SHIMPEI
    权利人:BREITENSTEIN WERNER; ERHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; MASUYA KEIICHI; KONISHI KAZUHIDE; YOKOKAWA FUMIAKI; KANAZAWA TAKANORI; JACOBY EDGAR; MARZINZIK ANDREAS; GROSCHE PHILIPP; KAWAKAMI SHIMPEI; NOVARTIS AG
    摘要:The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The preferred compounds (which can also be present as salts) have the formula I wherein R1, R2, T, R3 and R4 are as defined in the specification.

    专利号:US-9126942-B2
    优先权日:2008-03-08
    标题 :Arylsulfonyl pyrazoline carboxamidine derivatives as 5-HT6 antagonists
    发明人:VAN LOEVEZIJN ARNOLD; IWEMA BAKKER WOUTER I; STOIT ALEX; RENSINK AGATHA M; VENHORST JENNIFER; VAN DER NEUT MARTINA A W; DE HAAN MARTIN; KRUSE CORNELIS G
    权利人:ABBVIE BAHAMAS LTD
    摘要:This invention concerns arylsulfonyl pyrazoline carboxamidine derivatives as antagonists of 5-ht6 receptors, to methods for the preparation of these compounds and to novel intermediates useful for their synthesis. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in Parkinson's disease, Huntington's chorea, schizophrenia, anxiety, depression, manic depression, psychoses, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, binge eating disorders, panic attacks, akathisia, attention deficit hyperactivity disorder, attention deficit disorder, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, disorders associated with spinal trauma or head injury, hydrocephalus, functional bowel disorder, irritable bowel syndrome, obesity and type-2 diabetes. The compounds have the general formula (1) wherein the symbols have the meanings given in the description.
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    合成参考文献


    摘要:Zhang, M.; Su, W., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 127.
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