CAS: 93635-76-8; (2S,3R)-Ethyl 3-((R)-2,2-Dimethyl-1,3-Dioxolan-4-yl)-2,3-Dihydroxy-2-Methylpropanoate

该化合物是一个化学化合物,其复杂结构的特征是多种功能组,包括酯类和氢氧基组;该化合物是一种手性分子,在指定的碳中心拥有特定的立体化学,能够影响其生物活动和相互作用;二氧基环的存在有助于其稳定性,并可能影响其溶解性和再活性;通常,这种性质化合物在药物,农用化学品或有机合成中间体中的潜在应用会受到研究;立体化学和功能组表明,它可能与生物目标有特定互动,因此对药用化学感兴趣;此外,乙酸酯细胞表明,它可能参与化学中常见的化反应或水解.总的来说,这种化合物会揭示各种化学应用中使用的有机分子的复杂性和多样性.

英文名称(2S,3R)-Ethyl 3-((R)-2,2-Dimethyl-1,3-Dioxolan-4-yl)-2,3-Dihydroxy-2-Methylpropanoate
中文名称2-C-甲基-4,5-O-(1-甲基乙烯基)-D-阿拉伯糖酸乙酯
IUPAC名称ethyl (2S,3R)-3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxy-2-methylpropanoate
其它别名(2S,3R)-3-((4R)-2,2-二甲基二氧杂戊环-4-基)-2-甲基-2,3-二羟基丙酸; Ethyl (2S,3R)-3-[(4R)-2,2-Dimethyl-1,3-Dioxolan-4-Yl]-2,3-Dihydroxy-2-Methyl-Propanoate
CAS编号93635-76-8
MFCD编号:MFCD11112138
分子式:C11H20O6
分子量:248.27
产品CID: 1976168
产品分类有机原料→生命科学→糖类

相似结构搜索
InChIKey: BHCHXRCKXIVVCN-XLDPMVHQSA-N
InChI=1S/C11H20O6/c1-5-15-9(13)11(4,14)8(12)7-6-16-10(2,3)17-7/h7-8,12,14H,5-6H2,1-4H3/t7-,8-,11+/m1/s1…
计算化学: 氢键受体数6.0氢键供体数2.0可旋转键数4.0

相似化合物

93636-26-1 1946820-88-7 114185-07-8

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi

上下游产品

CAS号874638-80-9 (2R)-2-脱氧-2-氟-2... | CAS号7392-74-7 2, 3, 5-三苯甲酰氧基-...

合成工艺路线路线简述

130606-67-6 = 93635-76-8
反应条件:1.1 Catalysts: 1H-Imidazolium,1,3-Didodecyl-2-Methyl-,Chloride (1:1) Solvents: Acetone; 10 Min,Rt; Rt -> 0 °C1.2 Reagents: Permanganic Acid (Hmno4),Potassium Salt (1:1); 2 H,0 - 5 °C1.3 Reagents: Sodium Bisulfite Solvents: Water
标题:Dihydroxylation Of Olefins With Potassium Permanganate Catalyzed By Imidazolium Salt
作者:Khan,Imran; Luo,Zhi-Bin; Valeru,Anil; Xu,Yin; Liu,Bin; Et Al
参考文献:Synthesis 日期:2018 卷标:50(9) 页码:1815-1819]

81997-76-4 = 93635-76-8
反应条件:1.1 Reagents: Benzyltriethylammonium Chloride,Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Acetone; 3 H,Rt; Rt -> 0 °C1.2 5 Min,< 5 °C; 30 Min,0 °C1.3 Reagents: Sodium Bisulfite Solvents: Water
标题:An Efficient And Practical Method For Olefin Dihydroxylation
作者:Luo,Zhi-Bin; Zhao,Chen; Xie,Jimin; Lu,Hong-Fei
参考文献:Synthesis 日期:2016 卷标:48(21) 页码:3696-3700]

81997-76-4 = 93635-76-8
反应条件:1.1 Reagents: Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Acetone; 5 H,0 - 5 °C
标题:Bi- And Monocyclic Nucleoside Analogs For Treatment Of Hepatitis E
参考文献:World Intellectual Property Organization]

130606-67-6 = 93635-76-8
反应条件:1.1 Reagents: Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Acetone; 5 H,0 - 5 °C1.2 Reagents: Sodium Sulfite Solvents: Water
标题:Preparation Of Substituted Nucleosides,Nucleotides And Analogs Thereof As Antitumor And Hcv Antiviral Agents
参考文献:World Intellectual Property Organization]

81997-76-4 = 93635-76-8
反应条件:1.1 Reagents: Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Acetone; 0 - 5 °C; 2 H,0 - 5 °C1.2 Reagents: Sodium Sulfite Solvents: Water; 2 H,0 - 5 °C
标题:Preparation Of Substituted Nucleosides,Nucleotides And Analogs Thereof As Antiviral Agents
参考文献:World Intellectual Property Organization]

= 93635-76-8 [标题:Reaction Conditions
标题:Branched-Chain Sugars,Part Vii. Synthesis Of Saccharinic Acid Derivatives
作者:Lopez Aparicio,Fidel J.; Izquierdo Cubero,Isidoro; Portal Olea,Maria D.
参考文献:Carbohydrate Research 日期:1984 卷标:129 页码:99-109]

15186-48-8 + 535-11-5 = 93635-76-8
反应条件:1.1 Reagents: Triphenylphosphine Solvents: Water; Rt -> 80 °C; 15 - 18 H,70 - 80 °C1.2 Solvents: Dichloromethane; 0 - 5 °C; 0.5 H,0 - 5 °C1.3 Reagents: Sodium Hydroxide Solvents: Water; 5 °C -> 25 °C; 1 - 3 H,20 - 25 °C1.4 Reagents: Potassium,Sodium Chlorite Solvents: Tert-Butanol,Water; Rt; 24 H,Rt1.5 Reagents: Water,Sodium Sulfite
标题:Method For Preparing Ethyl 2-C-Methyl-4,5-O-(1-Methylethylidene)-D-Arabinate
参考文献:China]

130606-67-6 = 93635-76-8
反应条件:1.1 Reagents: Ethylene Glycol,Sodium Bicarbonate,Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Acetone,Water; 2 H,-10 °C; 1 H,-10 °C1.2 Reagents: Sodium Bisulfite Solvents: Water
标题:Preparation Of 2'-Disubstituted Nucleoside And Nucleotide Triphosphate Derivatives And Their Use As Anti-Hcv And Antiviral Agents
参考文献:World Intellectual Property Organization]

130606-67-6 = 93635-76-8
反应条件:1.1 Reagents: Ethylene Glycol,Sodium Bicarbonate,Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Acetone,Water; 2 H,-10 °C; 1 H,-10 °C1.2 Reagents: Sodium Bisulfite Solvents: Water
标题:Preparation Of 2'-Cyano Nucleoside And Nucleotide Triphosphate Derivatives And Their Use As Anti-Hcv And Antiviral Agents
参考文献:World Intellectual Property Organization]

81997-76-4 = 93635-76-8
反应条件:1.1 Reagents: Ethylene Glycol,Sodium Bicarbonate,Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Acetone,Water; 2 H,-10 °C; 1 H,-10 °C1.2 Reagents: Sodium Bisulfite Solvents: Water
标题:Preparation Of 2'-Substituted Nucleoside Derivatives And Methods Of Use Thereof For The Treatment Of Viral Diseases
参考文献:World Intellectual Property Organization]

130606-67-6 = 93635-76-8
反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: Acetone,Ethylene Glycol; -20 - -15 °C1.2 Reagents: Sodium Permanganate Solvents: Water; 1.5 H,-20 - -15 °C1.3 Reagents: Sodium Bisulfite Solvents: Water; 1 H,0 - 5 °C
标题:Preparation Method Of Intermediate Of Sofosbuvir
参考文献:China]

81997-76-4 = 93635-76-8
反应条件:1.1 Reagents: Ethylene Glycol,Sodium Bicarbonate,Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Acetone,Water; 1 H,-15 - -10 °C; 1 H,-15 - -10 °C1.2 Reagents: Sodium Bisulfite Solvents: Water; < 4 °C
标题:Preparation Of 2'-Cyano Substituted Nucleoside Derivatives And Methods Of Use Thereof For The Treatment Of Viral Diseases
参考文献:Canada]

81997-76-4 = 93635-76-8
反应条件:1.1 Reagents: Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Acetone; 2 H,0 - 5 °C1.2 Reagents: Sodium Sulfite Solvents: Water; 2 H
标题:Prepn Of Substituted Nucleosides,Nucleotides And Analogs Thereof As Antiviral Agents
参考文献:United States]

81997-76-4 = 93635-76-8
反应条件:1.1 Reagents: Ethylene Glycol,Sodium Bicarbonate,Sodium Permanganate Solvents: Ethyl Acetate; -10 - -5 °C; -5 °C -> 0 °C; 0 - 10 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water
标题:Process For Preparation Of 3,5-Dibenzoyl-2-Deoxy-2-Fluoro-2-Methyl-D-Ribose-γ-Lactone
参考文献:China]

= 93635-76-8 [标题:Reaction Conditions
标题:Improved Synthesis Method Of Sofosbuvir Drug For Treatment Of Hepatitis C By Using Sodium Permanganate Oxidizer,Tin Tetrachloride Catalyst And Pentafluorophenol
参考文献:China]

= 93635-76-8 [标题:Reaction Conditions
标题:2'-Cyano Substituted Nucleoside Derivatives And Methods Of Use Thereof For The Treatment Of Viral Diseases
参考文献:United States]

= 93635-76-8 [标题:Reaction Conditions
标题:Preparation Of Alkyl-Substituted 2-Deoxy-2-Fluoro-D-Ribofuranosyl Pyrimidine And Purine Nucleoside Analogs Via Condensation Of The Lactone To Nucleosides As Potential Antiviral Agents
参考文献:World Intellectual Property Organization

(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-甲醛置于potassium Permanganate,水,碳酸氢钠体系中,用二氯甲烷作为反应溶剂,化学反应生成 2-C-甲基-4,5-O-(1-甲基乙烯基)-D-阿拉伯糖酸乙酯
参考文献:2'-Azido Substituted Nucleoside Derivatives And Methods Of Use Thereof For The Treatment Of Viral Diseases
标题:2'-Azido Substituted Nucleoside Derivatives And Methods Of Use Thereof For The Treatment Of Viral Diseases
摘要:本发明涉及式(I)的2'-叠氮基取代核苷衍生物及其药学上可接受的盐,其中b,X,R1,R2和r3如本文所定义.本发明还涉及包含至少一种2'-叠氮基取代核苷衍生物的组合物,以及使用这些2'-叠氮基取代核苷衍生物治疗或预防患者hcv感染的方法.

海关参考信息

2905122000-异丙醇
2905143000-叔丁醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-9376410-B2
优先权日:2012-10-10
标题 :(2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone and preparation method and use thereof
发明人：WANG GUAN; JIANG XIANGRUI; GONG XUDONG; CHEN WEIMING; ZHU FUQIANG; ZHANG RONGXIA; ZHAO XIANGUO
权利人:TOPHARMAN SHANGHAI CO LTD; SHANGHAI INST MATERIA MEDICA; TOPHARMAN SHANDONG CO LTD; SHANGHAI INST MATERIA MEDICA
摘要:This invention disclose (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone in a single configuration and preparation method and use thereof. The (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone, or a pharmaceutically acceptable salt, an ester, a prodrug or a solvate thereof according to the invention are important intermediates of a variety of anti-viral and anti-tumor active ingredients. A compound obtained from (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone via an acylation reaction can be directly used for preparing various anti-viral and anti-tumor drugs. The Chiral synthesis method and the spontaneous resolution method of the compound of (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone according to the invention have the following advantages: the reaction routes are short and simple with high yield and low cost, which are suitable for industrial application.