CAS: 102368-13-8; 1,1'-Thiocarbonylbis(Pyridin-2(1H)-One)

该化合物是一种化学化合物,具有硫碳基功能组,由丙烯酸产生.该化合物一般在室温中呈现固态,具有独特的结构特性,包括存在两个由三碳基化合物组相连的丙烯基酮环,具有独特的结构特性.由于能够形成协调综合体,并具有对核糖核素的再活动性,因此在各个领域,包括医药化学和材料科学领域都具有潜在用途.该化合物还可能显示有趣的生物活动,使其成为药理学研究的主体.其溶性因溶剂不同而不同,并可能在其NMR和IR光谱学等技术中展示具体的光谱特性,这些技术可用来证实其结构.

结构式图片

相似化合物

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CAS号96989-50-3 二-2-吡啶基 硫碳酸 | CAS号111079-46-0 3-碘吡啶-2(1H)-酮 | CAS号3125-77-7 1,3-亚苯基二异硫氰酸 | CAS号20628-59-5 1,3-dioxolane-2... | CAS号2076-56-4 4-溴异硫氰酸苄酯 | CAS号103-72-0 异硫氰酸苯酯 | CAS号590-42-1 叔丁基异硫酸酯 | CAS号622-78-6 异硫氰酸苄酯 | CAS号621-30-7 间甲苯异硫氰酸酯 | CAS号19241-24-8 4-叔丁基苯异硫氰酸酯 | CAS号2284-20-0 4-甲氧基苯基 异硫氰酸酯

合成工艺路线路线简述

  • 合成目标产物 1,1'-Thiocarbonyldi-2(1H)-Pyridone 主要起始原料 Di-2-Pyridyl Thionocarbonate
  • (文献来源)合成步骤主要原料 Di-2-Pyridyl Thionocarbonate
二吡啶硫碳酸酯 以 甲苯 用作溶剂,化学反应 12.0H,以95%的收率获得1,1'-硫代羰基二-2(1H)-吡啶酮
参考文献:1,1'-Thiocarbonyldi-2,2'-Pyridone. A New Useful Reagent For Functional Group Conversions Under Essentially Neutral Conditions
标题:1,1'-Thiocarbonyldi-2,2'-Pyridone. A New Useful Reagent For Functional Group Conversions Under Essentially Neutral Conditions
摘要:
Doi:10.1021/jo00363A046

专利信息


专利号:US-8062756-B2
优先权日:2005-08-26
标题:Stepwise growth of oligomeric redox-active molecules on a surface without the use of protecting groups
发明人:BOCIAN DAVID F; LINDSEY JONATHAN S; JIAO JIEYING
权利人:BOCIAN DAVID F; LINDSEY JONATHAN S; JIAO JIEYING; REGENTS OFT THE UNIVERSITY OF CALIFORNIA; UNIV NORTH CAROLINA STATE
摘要:This invention provides a procedure for growing oligomers via a stepwise process. The oligomers can include porphyrins, which have been previously shown to be attractive candidates for molecular-based information storage. The stepwise synthesis procedure requires no protecting groups, thus eliminating protection/deprotection reactions that add complexity to the process.

专利号:US-2003009034-A1
优先权日:2001-03-22
标题 :Transition metal mediated process
发明人:WISHART NEIL; RITTER KURT
摘要:This invention relates to a transition metal mediated process for the preparation of optionally substituted 2-amino-benzoxazoles and or 2-amino-benzimidazoles, which are useful as therapeutic agents or as intermediates in the synthesis of therapeutic agents.

专利号:US-2003109714-A1
优先权日:2001-03-22
标题 :Transition metal mediated process
发明人:WISHART NEIL; RUDOLPH ALENA; RITTER KURT
摘要:This invention relates to a transition metal mediated process for the preparation of optionally substituted 2-amino-benzoxazoles and or 2-amino-benzimidazoles, which are useful as therapeutic agents or as intermediates in the synthesis of therapeutic agents.

专利号:WO-03055887-A1
优先权日:2001-12-21
标 题:Conjugated porphyrin, chlorin or bacteriochlorin chromophore
发明人:BOYLE ROSS WILLIAM; GREENMAN JOHN
权利人:CATALYST BIOMEDICA LTD; BOYLE ROSS WILLIAM; GREENMAN JOHN
摘要:The invention provides a porphyrin, chlorin or bacteriochlorin chromophore, which chromophore comprises one conjugating meso substituent which comprises a conjugating group Z for covalently conjugating said chromophore to a protein so as to enable delivery of the chromophore to a selected biological target in vitro or in vivo, and one, two or three hydrophilic meso substituents, wherein the hydrophilicity of the chromophore is such that either on carrying out conjugation of said chromophore to said protein by way of incubating said chromophore and said protein for one hour under standard protein conjugation conditions in 10% DMSO/water buffered to pH 9, the percentage of non-covalently bound chromophore out of total protein-bound chromophore is 5% or less; or, where said protein is bovine serum albumin, on carrying out conjugation of said chromophore to said protein by way of incubating said chromophore and said protein for one hour under standard protein conjugation conditions in 10% DMSO/water buffered to pH 9, the percentage of non-covalently bound chromophore out of total protein-bound chromophore is 20% or less. The invention further provides methods for the synthesis of such chromophores, and methods for the use of such chromophores in therapy and in analysis.

专利号:WO-2023250107-A1
优先权日:2022-06-23
标 题 :Process for preparing modulators of eukaryotic initiation factor 2b
发明人:BRAK KATRIEN; HALE CHRISTOPHER; SUDHAKAR ANANTHA
权利人:DENALI THERAPEUTICS INC
摘要:The present disclosure relates generally to methods for the preparation of Compound (I-1): I-1 or a stereoisomer or mixture of stereoisomers thereof, or salt of each thereof, as well as compounds and salts which are useful in the synthesis thereof.

专利号:US-8372971-B2
优先权日:2004-08-25
标 题:Heterocyclic compounds and methods of use
发明人:WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
权利人:TARGEGEN INC; WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
摘要:Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.
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主要参考文献

[参考文献]: Andrey S Klymchenko, Et Al. Excited-State Intramolecular Proton Transfer Distinguishes Microenvironments In Single- And Double-Stranded Dna. J Phys Chem B. 2008 Sep 25;112(38):12050-5.
[参考文献]: C Clifford Conaway, Et Al. Phenethyl Isothiocyanate And Sulforaphane And Their N-Acetylcysteine Conjugates Inhibit Malignant Progression Of Lung Adenomas Induced By Tobacco Carcinogens In A/j Mice. Cancer Res. 2005 Sep 15;65(18):8548-57.

合成参考文献


摘要:Braverman, S.; Cherkinsky, M.; Birsa, M. L., Science of Synthesis, (2005) 18, 266.
摘要:Braverman, S.; Cherkinsky, M.; Birsa, M. L., Science of Synthesis, (2005) 18, 200.
摘要:Jung, K. W.; Nagle, A. S., Science of Synthesis, (2005) 18, 420.
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