二吡啶硫碳酸酯 以 甲苯 用作溶剂,化学反应 12.0H,以95%的收率获得1,1'-硫代羰基二-2(1H)-吡啶酮 参考文献:1,1'-Thiocarbonyldi-2,2'-Pyridone. A New Useful Reagent For Functional Group Conversions Under Essentially Neutral Conditions 标题:1,1'-Thiocarbonyldi-2,2'-Pyridone. A New Useful Reagent For Functional Group Conversions Under Essentially Neutral Conditions 摘要: Doi:10.1021/jo00363A046
专利信息
专利号:US-8062756-B2 优先权日:2005-08-26 标题:Stepwise growth of oligomeric redox-active molecules on a surface without the use of protecting groups 发明人:BOCIAN DAVID F; LINDSEY JONATHAN S; JIAO JIEYING 权利人:BOCIAN DAVID F; LINDSEY JONATHAN S; JIAO JIEYING; REGENTS OFT THE UNIVERSITY OF CALIFORNIA; UNIV NORTH CAROLINA STATE 摘要:This invention provides a procedure for growing oligomers via a stepwise process. The oligomers can include porphyrins, which have been previously shown to be attractive candidates for molecular-based information storage. The stepwise synthesis procedure requires no protecting groups, thus eliminating protection/deprotection reactions that add complexity to the process.
专利号:US-2003009034-A1 优先权日:2001-03-22 标题 :Transition metal mediated process 发明人:WISHART NEIL; RITTER KURT 摘要:This invention relates to a transition metal mediated process for the preparation of optionally substituted 2-amino-benzoxazoles and or 2-amino-benzimidazoles, which are useful as therapeutic agents or as intermediates in the synthesis of therapeutic agents.
专利号:US-2003109714-A1 优先权日:2001-03-22 标题 :Transition metal mediated process 发明人:WISHART NEIL; RUDOLPH ALENA; RITTER KURT 摘要:This invention relates to a transition metal mediated process for the preparation of optionally substituted 2-amino-benzoxazoles and or 2-amino-benzimidazoles, which are useful as therapeutic agents or as intermediates in the synthesis of therapeutic agents.
专利号:WO-03055887-A1 优先权日:2001-12-21 标 题:Conjugated porphyrin, chlorin or bacteriochlorin chromophore 发明人:BOYLE ROSS WILLIAM; GREENMAN JOHN 权利人:CATALYST BIOMEDICA LTD; BOYLE ROSS WILLIAM; GREENMAN JOHN 摘要:The invention provides a porphyrin, chlorin or bacteriochlorin chromophore, which chromophore comprises one conjugating meso substituent which comprises a conjugating group Z for covalently conjugating said chromophore to a protein so as to enable delivery of the chromophore to a selected biological target in vitro or in vivo, and one, two or three hydrophilic meso substituents, wherein the hydrophilicity of the chromophore is such that either on carrying out conjugation of said chromophore to said protein by way of incubating said chromophore and said protein for one hour under standard protein conjugation conditions in 10% DMSO/water buffered to pH 9, the percentage of non-covalently bound chromophore out of total protein-bound chromophore is 5% or less; or, where said protein is bovine serum albumin, on carrying out conjugation of said chromophore to said protein by way of incubating said chromophore and said protein for one hour under standard protein conjugation conditions in 10% DMSO/water buffered to pH 9, the percentage of non-covalently bound chromophore out of total protein-bound chromophore is 20% or less. The invention further provides methods for the synthesis of such chromophores, and methods for the use of such chromophores in therapy and in analysis.
专利号:WO-2023250107-A1 优先权日:2022-06-23 标 题 :Process for preparing modulators of eukaryotic initiation factor 2b 发明人:BRAK KATRIEN; HALE CHRISTOPHER; SUDHAKAR ANANTHA 权利人:DENALI THERAPEUTICS INC 摘要:The present disclosure relates generally to methods for the preparation of Compound (I-1): I-1 or a stereoisomer or mixture of stereoisomers thereof, or salt of each thereof, as well as compounds and salts which are useful in the synthesis thereof.
专利号:US-8372971-B2 优先权日:2004-08-25 标 题:Heterocyclic compounds and methods of use 发明人:WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA 权利人:TARGEGEN INC; WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA 摘要:Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.
[参考文献]: Andrey S Klymchenko, Et Al. Excited-State Intramolecular Proton Transfer Distinguishes Microenvironments In Single- And Double-Stranded Dna. J Phys Chem B. 2008 Sep 25;112(38):12050-5. [参考文献]: C Clifford Conaway, Et Al. Phenethyl Isothiocyanate And Sulforaphane And Their N-Acetylcysteine Conjugates Inhibit Malignant Progression Of Lung Adenomas Induced By Tobacco Carcinogens In A/j Mice. Cancer Res. 2005 Sep 15;65(18):8548-57.
合成参考文献
摘要:Braverman, S.; Cherkinsky, M.; Birsa, M. L., Science of Synthesis, (2005) 18, 266. 摘要:Braverman, S.; Cherkinsky, M.; Birsa, M. L., Science of Synthesis, (2005) 18, 200. 摘要:Jung, K. W.; Nagle, A. S., Science of Synthesis, (2005) 18, 420.