CAS: 10523-68-9; Adamantan-2-Amine Hydrochloride

相似化合物

13074-39-0 1501-84-4 665-66-7

上下游产品

CAS号75375-89-2 4-氨基-1-金刚烷醇 | CAS号126947-71-5 N-(2-adamantyl)... | CAS号103951-51-5 N-(2-adamantyl)... | CAS号13074-39-0 2-金刚烷胺 | CAS号52917-72-3 adamantanacetamide | CAS号63664-40-4 N-(2-adamantyl)...

金刚烷酮置于dicobalt Phosphide,Ammonium Acetate,氢气,盐酸体系中,用 乙醇,1,4-二氧六环 用作溶剂,100.0 °C,1.0 Mpa 条件下,以88 %的收率获得2-金刚烷胺盐酸盐
参考文献:单晶磷化钴纳米棒作为羰基化合物还原胺化的高性能催化剂
标题:单晶磷化钴纳米棒作为羰基化合物还原胺化的高性能催化剂
摘要:用于有机合成的金属磷化物催化剂的开发仍处于早期阶段.在此,我们报告了含有配位不饱和 Co-Co 活性位点的单晶磷化钴纳米棒 (Co 2 P Nrs)的成功合成,其作为一类新型的空气稳定,高活性和可重复使用的非均相催化剂用于还原反应.羰基化合物的胺化.Co 2 P Nr 催化剂在使用氨水溶液或乙酸铵作为绿色胺化试剂在 1 巴的 H 2压力下将范围广泛的羰基化合物转化为其相应的伯胺方面表现出高活性;这些情况比以前报道的要温和得多.Co 2的空气稳定性和高活性p Nrs 值得注意,因为传统的 Co 催化剂对空气敏感(自燃)并且在温和条件下没有显示出这种转化的活性.因此,P 合金化对于用于有机合成的纳米工程空气稳定和高活性非贵金属催化剂具有相当重要的意义.
Doi:10.1021/jacsau.1C00125

专利信息

专利号:US-5075450-A
优先权日:1990-06-28
标 题 :Intermediates in the synthesis of 17β-acyl-3-carboxy-androsta-3,5-dienes
发明人：RASMUSSON GARY H; TOLMAN RICHARD L; PATEL GOOL F
权利人:MERCK & CO INC
摘要:New intermediates in the synthesis of 17β-acyl-3-carboxy-androsta-3,5-dienes, of the formula: ##STR1## wherein R 2 is 2-thiopyridyl, and n R 3 is C 2 -C 4 alkoxycarbonyl, C 1 -C 4 , or trifluoromethylsulfonyloxy. The above compounds are useful intermediates in producing testosterone 5α-reductase inhibitors which are useful topically for treatment of acne, seborrhea, female hirsutism, and systemically in treatment of benign prostatic hypertrophy.

专利号:US-2011015119-A1
优先权日:2009-06-24
标题:Novel semi-synthetic glycopeptides as antibacterial agents
发明人：CHU DANIEL; YE TAO; WANG BING
权利人:LEAD THERAPEUTICS INC
摘要:Semi-synthetic glycopeptides having antibacterial activity are described, in particular, the semi-synthetic glycopeptides described herein are made by chemical modification of a glycopeptide (Compound A, Compound B, Compound H or Compound C) or monosaccharide made by hydrolyzing the disaccharide moiety of the amino acid-4 of the parent glycopeptide in acidic medium to give the amino acid-4 monosaccharide; conversion of the monosaccharide to the amino-sugar derivative; acylation of the amino substituent on the amino acid-4 amino-substituted sugar moiety on these scaffolds with certain acyl groups; and conversion of the acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides. Key reaction is the treatment of properly protected intermediate compound with isocyanate. Also provided are methods for the synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.

专利号:EP-0465123-A2
优先权日:1990-06-28
标题:New intermediates in the synthesis of 17beta-acyl-3-carboxy-androsta-3,5-dienes

专利号:US-5596020-A
优先权日:1993-06-25
标题:Amino bi- and tri-carbocyclic alkane bis-aryl squalene synthase inhibitors
发明人：MORRIS ROBERT L; NEUENSCHWANDER KENT W; LEARN KEITH S; SCOTESE ANTHONY C
权利人:RHONE POULENC RORER PHARMA
摘要:This invention relates to a class of novel amino bi- and tri-carbocyclic alkane compounds having bis-aryl substitution which exhibit squalene synthase inhibition properties. The bi- and tri-carbocyclic alkane ring contains an amino group and the ring is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

专利号:RU-2453552-C2
优先权日:2010-06-18
标题 :Semi-synthetic analogues of aureolic acid olivomycin a antibiotic, having anti-tumour activity, and synthesis method thereof

专利号:RU-2151143-C1
优先权日:1993-11-15
标题:Substituted 5-membered heterocycles, method of their synthesis, pharmaceutical composition