CAS: 109581-93-3; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26As)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-Hexadecahydro-5,19-Dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-Hydroxy-3-Methoxycyclohexyl]-1-Methylethenyl]-14,16-Dimethoxy-4,10,12,18-Tetramethyl-8-(2-Propen-1-yl)-15,19-E

专利信息

专利号:US-11505534-B2
优先权日:2017-05-16
标题:Highly diastereoselective construction of the 4,5-spirocycle via palladium-catalyzed intramolecular alkenylation
发明人：XIE JIAXIN; DONG GUANGBIN
权利人:UNIV CHICAGO
摘要:A diastereoselective method of preparing benzofuran-based 4,5-spirocycles via metal catalyzed alkenylation is described. The method can be used to provide compounds containing the benzofuranone-4,5-spirocyclic motif of the phainanoids, a class a natural products having immunosuppressive activity. Synthetic analogs of phainanoids, e.g., compounds that mimic the structure of the “westernâ€? part of the structure of the phainanoids and that contain the benzofuranone-4,5-spirocycle are described, as well as their synthetic intermediates, and their methods of synthesis.

专利号:JP-H07508015-A
优先权日:1992-06-30
标题 :Synthesis of 1,4,7-triazacyclononane derivatives

专利号:KR-20200065031-A
优先权日:2017-10-04
标 题:Synthesis of cantharidin

专利号:US-2022274997-A1
优先权日:2019-04-29
标题:Pim kinase inhibitor compositions and uses thereof
发明人：BURK MARK J; CHEN BRANDON
权利人:SNAP BIO INC
摘要:This disclosure relates to compounds and compositions useful as inhibitors of PIM kinases. Also provided are methods of synthesis and methods of use of PIM inhibitors in treating individuals suffering from cancerous malignancies.

专利号:US-11319320-B2
优先权日:2017-11-06
标题:PIM kinase inhibitor compositions, methods, and uses thereof
发明人：BURK MARK J; CHEN BRANDON; LI JINGYI; BACHAN SHAWN
权利人:SNAP BIO INC
摘要:This application relates to compounds of formulae (I) and (II) and compositions thereof useful as inhibitors of PIM kinases. Also provided are methods of synthesis and methods of use of PIM inhibitors in treating individuals suffering from cancerous malignancies.