合成目标产物 N,N,N',N'-Tetramethylethylenediamine 主要起始原料 Dimethylamine And Acetylene
(文献来源)合成步骤主要原料 Dimethylamine 和 Acetylene
丙烯腈置于四甲基乙二胺,三氯硅烷体系中,化学反应生成四甲基乙二胺 参考文献:Catalysts For Addition Of Siicon Hydrides To .Alpha.,.Beta.-Unsaturated 标题:Catalysts For Addition Of Siicon Hydrides To .Alpha.,.Beta.-Unsaturated 摘要:本发明是一种制备水解性β-氰基烷基硅烷的方法.更具体地说,本发明涉及利用新型催化剂将水解性硅氢化合物加成到α,β-不饱和烯丙基腈中,形成β-氰基烷基硅烷.本方法采用新型催化剂,包括二胺和非活化铜,选择的无机铜化合物或二配位有机铜化合物.
专利号:WO-2012017400-A1 优先权日:2010-08-03 标 题 :Synthesis of acyl-pantetheine derivatives and the use thereof in the synthesis of acyl-coenzyme a derivatives 发明人:VAN DIJK ALBERDINA AIKE; BADENHORST CHRISTOFFEL PETRUS STEPHANUS 权利人:UNIV NORTHWEST; VAN DIJK ALBERDINA AIKE; BADENHORST CHRISTOFFEL PETRUS STEPHANUS 摘要:The present invention relates to a novel synthesis method for acyl-pantetheine derivatives. The present invention further relates to the use of said synthesized acyl-pantetheine derivatives as a starting material in the enzymatic synthesis of acyl-coenzyme A derivatives. According to a first aspect thereof, the present invention provides a method for the synthesis of acyl-pantetheine derivatives, the method including the steps of: a) providing a source of pantetheine; b) providing a source of acyl ester; and c) contacting the source of pantetheine with the source of acyl ester to form the corresponding acyl-pantetheine derivative, having the general formula (I), wherein R is an acyl group.The present invention also provides a method for the synthesis of acyl-coenzyme A derivatives as well as the use of a source of pantetheine and a source of acyl ester in the preparation steps of these two methods.
专利号:US-11938187-B2 优先权日:2021-06-10 标题:Methods and compositions for synthesis of two-photon cleavable phosphoramidite molecules for oligonucleotide conjugation 发明人:LO PEGGY PIK KWAN; LIU LING SUM; TAM DICK YAN 权利人:UNIV CITY HONG KONG 摘要:The syntheses of two phosphoramidite building blocks based on BNSF and BNSMB structures are disclosed. Furthermore, some common molecular intermediates have been designed and linked to the central biphenyl core of the two molecules, resulting in a versatile and cost-effective design. These compounds can be effectively introduced to DNA oligonucleotides via the well-established standard cyanoethylphosphoramidite chemistry on the nucleic acid synthesizer. Fragmentation of these BNSF- and BNSMB-functionalized DNA strands is achieved by both one-photon and two-photon photolysis of photoliable bonds of [2-(2-nitrophenyl)propoxy]carbonyl groups on BNSF and BNSMB molecules respectively, resulting in two short pieces of single-stranded DNAs. The versatile design and facile synthesis of these two-photon photocleavage phosphoramidite molecules are beneficial to synthetic chemists and photochemists for the development of new caged compounds which enables to introduce into oligonucleotides as light-triggered carriers via solid-phase synthesis for a wide range of applications in materials science, polymer, chemistry, biology and DNA nanoecthnology.
专利号:WO-2022256490-A9 优先权日:2021-06-03 标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus 发明人:LOCKWOOD MARK 权利人:ANTIOS THERAPEUTICS INC 摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.
专利号:US-2021107859-A1 优先权日:2018-04-06 标题 :A process for the synthesis of carbon labeled organic compounds 发明人:AUDISIO DAVIDE; CANTAT THIBAULT; DESTRO GIANLUCA 权利人:COMMISSARIAT ENERGIE ATOMIQUE 摘要:A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.
专利号:US-2006293466-A1 优先权日:2003-06-20 标 题:Methods for synthesis of graft polymers 发明人:GAUTHIER MARIO; YUAN ZHONGSHUN 权利人:UNIV WATERLOO 摘要:A process for the synthesis of arborescent polymers comprises epoxidation of a first polymer and grafting thereto a second polymer having groups reactive to the epoxide groups on the first polymer. The epoxidation and grafting steps can be repeated. In an additional embodiment, the present invention provides a one-pot method for the synthesis of arborescent polymers. In a reaction pot, a first polymer is copolymerized and then reacted with an activating compound in order to generate a polyfunctional macroinitiator. Monomers are then added to the reaction pot, the monomers having functional groups reactive towards reactive sites on the first polymer.
专利号:US-9643915-B2 优先权日:2013-03-15 标题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins 发明人:ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK 权利人:CERENIS THERAPEUTICS HOLDING SA 摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.
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