CAS: 123-76-2; 4-Oxopentanoic Acid

相似化合物

624-45-3 539-88-8 2854-10-6

上下游产品

CAS号9004-34-6 微晶纤维素 | CAS号50-99-7 D(+)-无水葡萄糖 | CAS号67-47-0 5-羟甲基糠醛 | CAS号57-48-7 果糖 | CAS号57-50-1 蔗糖 | CAS号98-00-0 糠醇 | CAS号1623-88-7 5-氯甲基呋喃-2-甲醛 | CAS号765-70-8 3-甲基-1,2-环戊二酮 | CAS号492-62-6 α-D-葡萄糖 | CAS号6089-09-4 4-戊炔酸 | CAS号74-89-5 氨基甲烷 | CAS号1070-35-5 allyl levulinate | CAS号112146-12-0 N,N-diethyl-4-h... | CAS号4743-82-2 3-乙酰基丙烯酸 | CAS号34272-65-6 (2,4-二甲基-1,3-噻唑... | CAS号60588-57-0 3-(2-Methyl-1,3... | CAS号53-86-1 吲哚美辛 | CAS号33528-35-7 己烷2,5-二酮单乙烯缩酮 | CAS号3884-71-7 5-溴-2-戊酮 | CAS号3249-33-0 4-羰基己酸乙酯

葡萄糖置于硫酸体系中,用 水 用作溶剂,化学反应 1.33H,以1065 Mg的收率获得乙酰丙酸
参考文献:布朗斯台德酸催化d-葡萄糖对5-Hmf的水热分解中使用的铵盐的影响
标题:布朗斯台德酸催化d-葡萄糖对5-Hmf的水热分解中使用的铵盐的影响
摘要:在这项工作中,我们比较了两种铵盐(硫酸铵和乙酸铵)作为促进剂在d-葡萄糖水热分解中的作用,以及在硫酸存在下获得的结果.首次,我们证明了由于d-葡萄糖的低转化率,乙酸铵不是很好的促进剂.相反,硫酸铵似乎是更有希望的促进剂.实际上,即使观测到大量的腐殖质,也以高产率获得了5-Hmf,并且d-葡萄糖快速转化.在分离和表征液相和固相后,对硫酸铵的作用进行了彻底的研究.从d获得的腐殖质的结构表征还提出了葡萄糖和铵盐.此外,我们证明了使用含铵促进剂时,部分氮原子以吡咯衍生物的形式插入腐殖质结构中.
Doi:10.1039/d0Nj00155D

专利信息

专利号:EP-4092127-A1
优先权日:2021-05-18
标题:Enzyme-catalytic method for the direct stereoselective synthesis of gamma-(acyloxy) carboxylic acids
发明人：PARVE JAAN; KUDRJASHOVA MARINA; GATHERGOOD NICHOLAS; PARVE OMAR
权利人:TALLINN UNIV OF TECHNOLOGY
摘要:The present invention is a method for the stereoselective straightforward synthesis of gamma-acyloxy carboxylic acids of novel structure starting from racemic gamma-hydroxy carboxylic acid salts that are obtained by alkaline hydrolysis of the racemic gamma-lactones. The salt is acylated by enzyme catalysis in an organic solvent containing an acyl donor and an immobilised lipase, on stirring at room temperature (ca 20 °C) until reaching the conversion rate required. After that, the reaction mixture is acidified and extracted and the product treated with catalytic amount of para-toluenesulfonic acid in toluene during the time required for the relactonisation of the unreacted salt enantiomer. Thereafter, the target gamma-acyloxy carboxylic acid formed from one enantiomer of the starting compound and relactonised gamma-lactone formed from the other, unreacted enantiomer of the starting compound are isolated using a routine separation method, such as distillation, extraction with NaHCO3 water solution followed by acidification or column chromatography.

专利号:US-7160517-B2
优先权日:2000-08-18
标题 :Apparatus and methods for the automated synthesis of oligosaccharides
发明人：SEEBERGER PETER H; PLANTE OBADIAH J
权利人:MASSACHUSETTS INST OF TECHNOLG
摘要:One aspect of the present invention relates to an apparatus for the efficient synthesis of oligosaccharides on a solid support, e.g., formed by subunit addition to terminal subunits immobilized on solid-phase particles. In certain embodiments, the apparatus of the present invention is used in combinatorial methods, e.g., as described herein, of synthesizing oligosaccharides.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-2024158926-A1
优先权日:2022-11-03
标 题 :Electrochemical synthesis of hydroxyvaleric acid from levulinic acid
发明人：HOLEWINSKI ADAM; DE SOUZA LUCAS FRANCISCO WILLIAN
权利人:UNIV COLORADO REGENTS
摘要:Disclosed herein are methods of electrochemical synthesis of hydroxyvaleric acid from levulinic acid. For example, disclosed herein are methods comprising electrochemical synthesis of hydroxyvaleric acid from levulinic acid, wherein the method is conducted in an electrochemical cell wherein a working electrode is in electrochemical contact with an aqueous electrolyte and levulinic acid, wherein the method comprises applying a potential to electrochemically reduce the levulinic acid to form hydroxyvaleric acid. Also disclosed herein are methods of synthesizing gamma-valerolactone from hydroxyvaleric acid, the method comprising acid-catalyzed esterification. Also disclosed herein are methods of use of the products produced by any of the methods herein.

专利号:US-2004242897-A1
优先权日:2002-07-31
标题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.