CAS: 162515-68-6; 2-(1-(Mercaptomethyl)Cyclopropyl)Acetic Acid

相似化合物

71199-15-0 70197-77-2 152922-73-1

上下游产品

1-(Acetylthiomethyl)cyclopropaneacetonitrile 2-[1-(mercaptomethyl)cyclopropyl]acetic acid methyl ester 1-bromomethylcyclopropyl acetic acid methyl ester (1-{(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-2-methoxymethoxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(methoxycarbonyl)phenyl]propyl]thio]methyl]-cyclopropane acetic acid potassium 1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetate montelukast

1-羟基甲基环丙烷乙酸甲酯置于n-溴代丁二酰亚胺(Nbs),水,硫脲,N,N'-二甲基硫脲,Lithium Hydroxide体系中,用 甲醇,乙醇,二氯甲烷 用作溶剂,化学反应 36.0H,反应生成1-巯甲基环丙基乙酸
参考文献:一种2(1-(巯基)环丙基)乙酸的制备方法
标题:一种2(1-(巯基)环丙基)乙酸的制备方法
摘要:本发明涉及一种2(1‑(巯基)环丙基)乙酸的制备方法,属于药物合成技术领域.为了解决提高产物纯度的问题,提供一种2(1‑(巯基)环丙基)乙酸的制备方法,该方法包括将式4化合物溶于有机溶剂中,加入n,N'‑二甲基硫脲与n‑溴代丁二酰亚胺,生成产物式3化合物,将式3化合物溶于有机溶剂中,加入硫脲,调节溶液ph为5,真空脱去溶剂后得到式2化合物,将式2化合物溶于有机溶剂中,加入水和无机碱,在氮气保护下加热反应,反应完成后调节ph为3.5,浓缩后得到最终产物式1化合物;本发明整体上具有产物生成率高,生产过程简单,操作安全性高,产物纯度高的优点.

专利信息

专利号:WO-2012020271-A1
优先权日:2010-08-11
标题 :Process for the preparation of montelukast sodium
发明人：BODI JOZSEF; FARAGO JANOS; SZOEKE KATALIN; UJVARI VIKTOR; TEMESVARI KRISZTINA; ARANYI ANTAL; SANTA ZSUZSANNA; NAGY MELINDA MAGDOLNA
权利人:RICHTER GEDEON NYRT; BODI JOZSEF; FARAGO JANOS; SZOEKE KATALIN; UJVARI VIKTOR; TEMESVARI KRISZTINA; ARANYI ANTAL; SANTA ZSUZSANNA; NAGY MELINDA MAGDOLNA
摘要:The present invention relates to a process for the synthesis of Montelukast sodium of formula I the chemical name of which is [(R)-(E)]-1-[[[1-[3-[2-(7-chloro-2- quinolinyl)ethenyl]phenyl] -3 - [2-( 1 -hydroxy- 1 -methylethyl)phenyl]propyl] thio]methyl] - -cyclopropaneacetic acid sodium salt. The present invention further provides compounds of general formulae V, VI, VIb and VIII as new intermediates.

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:WO-2011121091-A1
优先权日:2010-03-31
标题:Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein
发明人：KIDEMET DAVOR; BOGDAN STEFANE; KLJAJIC ALEN; BENKIC PRIMOZ; STROPNIK TADEJ; PLAPER IGOR
权利人:KRKA D D NOVO MESTO; KIDEMET DAVOR; BOGDAN STEFANE; KLJAJIC ALEN; BENKIC PRIMOZ; STROPNIK TADEJ; PLAPER IGOR
摘要:The present invention describes the improved process for the preparation of montelukast acid (VII) and its pharmaceutically acceptable salts and esters using a novel synthesis step. The process is cost effective, environment friendly, and easily scale up to commercial level and leads to products having high chemical and optical purity. Moreover, the present invention provides a novel crystalline intermediate (IV) that is useful in this process and a method for its production. In a further aspect, the process of the present invention includes a step of removing ketone by-products be derivatization.

专利号:US-2009099367-A1
优先权日:2006-03-06
标题 :Process for preparing a leukotriene antagonist
发明人：BESSA BELLMUNT JORDI; RAFECAS JANE LLORENC; PASTO AGUILA MIREIA; VERDAGUER ESPAULELLA XAVIER; GORDO CAMPON ESTHER
权利人:FARMAPROJECTS S A
摘要:Process for preparing montelukast or a pharmaceutically acceptable salt thereof, especially its sodium salt, that comprises the condensation of an aldehyde and 7-chloro-2-methylquinoline. Moreover, novel intermediates useful for the synthesis of montelukast are described as well as their preparation.

专利号:US-7786138-B2
优先权日:2005-11-18
标题 :Process for making montelukast and intermediates therefor
发明人：BENOVSKY PETR; THIJS LAMBERTUS; OVEREEM ARJANNE; CASTULIK JAKUB; ZHU JIE; BARTOS PETR; SKOUMAL RADOMIR
权利人:SYNTHON BV
摘要:A compound of the following formula n nwherein R′ is a straight or branched C1-C4 alkyl group is useful in processes associated with the synthesis of montelukast and its salts.

专利号:EP-2287154-A1
优先权日:2009-07-14
标题 :Efficient synthesis for the preparation of montelukast
发明人：KIDEMET DAVOR; BENKIC PRIMOZ; KLJAJIC ALEN; STEFANE BOGDAN
权利人:KRKA D D NOVO MESTO
摘要:The present invention describes the improved process for the preparation of montelukast acid and its pharmaceutically acceptable salts and esters. The process is cost effective, environment friendly, and easily scale up to commercial level.