CAS: 16475-90-4; Methyl 5-Acetyl-2-Hydroxybenzoate

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39235-58-0 13110-96-8 57009-12-8

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CAS号108-24-7 乙酸酐 | CAS号119-36-8 水杨酸甲酯 | CAS号67-56-1 甲醇 | CAS号13110-96-8 5-乙酰基水杨酸 | CAS号75-36-5 乙酰氯 | CAS号127-18-4 四氯乙烯 | CAS号64-19-7 冰醋酸 | CAS号50-78-2 阿司匹林 | CAS号580-02-9 乙酰水杨酸甲酯 | CAS号606-45-1 2-甲氧基苯甲酸甲酯 | CAS号24085-19-6 4-(2-氨基-1-羟基乙基)... | CAS号89365-50-4 沙美特罗 | CAS号72492-12-7 螺佐呋酮 | CAS号343338-97-6 methyl 5-acetyl... | CAS号36256-45-8 5-(2-溴乙酰基)-2-羟基苯甲酸甲酯 | CAS号13110-96-8 5-乙酰基水杨酸 | CAS号29754-58-3 3-甲酰甲氧基4-羟基苯基乙二醛 | CAS号27475-14-5 5-(2-溴乙酰基)-2-苄氧... | CAS号39971-36-3 5-乙酰基-2-甲氧基苯甲酸甲酯

阿司匹林置于三氯化铝,硫酸体系中,用 硝基苯 用作溶剂,化学反应 25.0H,反应生成5-乙酰水杨酸甲酯
参考文献:Synthesis And Structure-Activity Relationships Among .Alpha.-Adrenergic Receptor Agonists Of The Phenylethanolamine Type
标题:Synthesis And Structure-Activity Relationships Among .Alpha.-Adrenergic Receptor Agonists Of The Phenylethanolamine Type
摘要:Nineteen Arylethanolamine Derivatives Related To Norepinephrine Were Prepared And Tested For Alpha-Adrenergic Stimulant Activity. In One Series The Analogues Possess A P-Hydroxy Function,While The Meta Position Is Substituted By Methyl,Ethyl,Isopropyl,Chlohexyl,Fluoro,Chloro,Iodo,Carboxy,Carbomethoxy,And Methylsulfamido Groups. The Other Series Is Meta Hydroxylated With The Para Position Substituted By The Same Groups. The Influence Of These Groups Upon The Alpha-Adrenergic Activity Is Discussed,And The Compounds Are Compared To octopamine,Normetanephrine,Norepinephrine,And Norphenylephrine. It Has Been Found That The Introduction Of An Isopropyl,Cyclohexyl,And Fluoro Group In The Meta Position Of octopamine Improves Its Affinity By Three,Five,And Six Times,Respectively,Whereas When These Groups Are Introduced In The Para Position Of Norphenylephrine Their Effects Are Always Detrimental. The Most Active Compound,Alpha-(Aminomethyl)(4-Fluoro-3-Hydroxyphenyl)Methanol (44),Has About One-Hundredth The Affinity And The Same Intrinsic Activity As Norepinephrine.
Doi:10.1021/jm00181A008

专利信息

专利号:US-5442118-A
优先权日:1994-04-22
标题 :Asymmetric synthesis of (R)- and (S)-arylethanolamines from iminoketones
发明人：GAO YUN; HONG YAPING; ZEPP CHARLES M
权利人:SEPRACOR INC
摘要:A method for the enantioselective reduction of an alpha -iminoketone to an alpha -aminoalcohol is disclosed. The method utilizes a borane reducing agent as the reducing agent and a chiral 1,3,2-oxazaborole as the catalyst. The method is applied to the synthesis of R-albuterol from methyl 5-acetylsalicylate in high yield and high optical purity.

专利号:US-5877296-A
优先权日:1994-06-03
标题:Process for preparing conjugates of methyltrithio antitumor agents
发明人：HAMANN PHILIP ROSS; HINMAN LOIS; HOLLANDER IRWIN
权利人:AMERICAN CYANAMID CO
摘要:This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

专利号:US-5739116-A
优先权日:1994-06-03
标题:Enediyne derivatives useful for the synthesis of conjugates of methyltrithio antitumor agents

专利号:EP-0766662-A1
优先权日:1994-04-22
标 题 :Asymmetric synthesis of (r)- and (s)-arylethanolamines from iminoketones

专利号:WO-9529146-A1
优先权日:1994-04-22
标 题:Asymmetric synthesis of (r)- and (s)-arylethanolamines from iminoketones

专利号:US-5767285-A
优先权日:1994-06-03
标题 :Linkers useful for the synthesis of conjugates of methyltrithio antitumor agents