CAS: 18704-37-5; Quinoline-8-Sulfonyl Chloride

相似化合物

159182-40-8 119373-30-7 74863-82-4

上下游产品

CAS号491-33-8 8-巯基喹啉 | CAS号1160-28-7 8,8-喹啉基二硫 | CAS号85-48-3 喹啉-8-磺酸 | CAS号91-22-5 喹啉 | CAS号35203-91-9 喹啉-8-磺酰胺 | CAS号16567-18-3 8-溴喹啉 | CAS号143850-33-3 but-3-ynyl quin... | CAS号2801-16-3 喹啉8-硫醇钠 | CAS号89-00-9 吡啶-2,3-二羧酸 | CAS号1160-28-7 8,8-喹啉基二硫 | CAS号35203-91-9 喹啉-8-磺酰胺 | CAS号116834-64-1 4-[(8-喹啉磺酰基)氨基]苯甲酸 | CAS号77244-88-3 3-NITRO-1-(8-QU... | CAS号880770-31-0 8-[(3-Bromo-1H-... | CAS号478263-90-0 5-fluoro-2-(qui... | CAS号491-33-8 8-巯基喹啉

8,8-喹啉基二硫置于盐酸,Sodium Hypochlorite体系中,用 氯仿,水 用作溶剂,化学反应 0.25H,反应生成喹啉-8-磺酰氯
参考文献:15N 标记的 N,N-二甲基氨磺酰基喹啉的 7 种位置异构体的合成,15N NMR 光谱和 Giao 计算数据
标题:15N 标记的 N,N-二甲基氨磺酰基喹啉的 7 种位置异构体的合成,15N NMR 光谱和 Giao 计算数据
摘要:摘要 介绍了n,N-二甲基氨磺酰基喹啉位置异构体的一步合成方法.七种新合成的化合物已通过元素分析,Ms,1 H 和 15 N NMR 光谱数据进行了表征.在 Ghmbc 实验中观测到环质子和环内氮原子之间的长程相关性.来自磺酰胺基团的氮原子的光谱位置是从 15 个 N 标记的磺酰胺同位素的一维光谱中得出的.发现了实验确定的化学位移和 Giao 计算的各向同性屏蔽常数之间的相关性.Giao 计算基于 Hf,Mp2 和 B3Lyp 优化的几何形状,并在 Hf,Blyp 和 B3Lyp 理论水平上进行.
Doi:10.1016/j.Molstruc.2012.01.049

专利信息

专利号:US-12139504-B2
优先权日:2022-08-09
标 题:Vanadium alkylidene complex, synthesis and use thereof
发明人：BUKHRYAKOV KONSTANTIN; BELOV DMITRY
权利人:BUKHRYAKOV KONSTANTIN; BELOV DMITRY; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides catalytical compounds/complexes, compositions comprising such compound/complex, synthesis of the compounds/complexes, and methods of using such compounds/complexes as catalysts in, for example, RCM reactions. Specifically, the subject invention provides the synthesis of the first catalytically active V oxo alkylidene, VO(CHSiMe 3 )(PEt 3 ) 2 Cl, which exhibits superior performance compared to other analogs.

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-11897827-B1
优先权日:2022-11-22
标 题 :Carbon isotope exchange mediated by vanadium complexes
发明人：BUKHRYAKOV KONSTANTIN
权利人:BUKHRYAKOV KONSTANTIN; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides catalytical compounds/complexes, compositions comprising such compound/complex, synthesis of the compounds/complexes, and methods of using such compounds/complexes as catalysts in, for example, carbon isotope exchange (CIE) on target bioactive molecules. Methods that allow CIE directly on drug candidates are of great importance to chemistry, biology, and medicine. Especially valuable are catalytic procedures that rely on a limited collection of available labeled materials. The instant method comprises converting a methyl group to terminal â•?CH2 utilizing transfer dehydrogenation catalysts to enable V-based olefin metathesis, followed by a hydrogenation step. The one-pot strategy allows the formal methylation/demethylation sequence and can be applied to an assortment of alkyl-containing compounds.

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-6872716-B2
优先权日:2000-09-11
标题:Antipsychotic sulfonamide-heterocycles, and methods of use thereof
发明人：WU XINHE; AQUILA BRIAN M; SHAO LIMING; RADEKE HEIKE; CUNY GREGORY D; HAUSKE JAMES R; XIE ROGER L
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds comprising a sulfonamide moiety. A second aspect of the present invention relates to the use of the heterocyclic compounds comprising a sulfonamide moiety to treat diseases, afflictions or maladies caused at least in part by abnormal activity of one or more GPCRs or ligand-gated ion channels. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds comprising a sulfonamide moiety, and the screening of those libraries for biological activity, e.g., in animal models of psychosis.

专利号:US-7579459-B2
优先权日:2005-12-12
标 题 :Activator bound solid supports for nucleic acid synthesis via the phosphoramidite approach
发明人：NGO NAM Q; JAQUINOD LAURENT
权利人:NGO NAM Q; JAQUINOD LAURENT
摘要:The present invention relates to improved methods for the preparation of nucleic acids. More particularly, conventional solid supports used for nucleic acid synthesis are derivatized with activators having pKas within the 4 to 7 range. Preferentially, CPG-based solid supports are reacted with trialkoxysilanes containing an activator moiety such as pyridine. During each deblocking step of the nucleic acid synthesis cycle, bound pyridiniums are generated, yielding a weak acidic medium spreads throughout the solid support. The bound activators efficiently activate the phosphoramidite reagents towards coupling with 5′-hydroxynucleosides bound to the solid supports, thus eliminating or supplementing external deliveries of activator during the coupling steps.