CAS: 2736-23-4; 2,4-Dichloro-5-Sulfamoylbenzoic Acid

上下游产品

CAS号3740-18-9 2,4-二氯-5-氯磺酰基苯甲酸 | CAS号50-84-0 2,4-二氯苯甲酸 | CAS号3861-99-2 4-氨基磺酰基-5-氯邻苯二甲酰亚胺 | CAS号3740-16-7 2,4-dichloro-5-... | CAS号4793-25-3 ethyl 2,4-dichl... | CAS号54109-03-4 5-氯-1(3H)-异苯并呋喃酮

2,4-二氯苯甲酸置于氯磺酸,Ammonium Hydroxide体系中,化学反应 7.0H,反应生成2,4-二氯-5-磺酰胺基苯甲酸
参考文献:一种呋塞米的制备方法
标题:一种呋塞米的制备方法
摘要:本发明属于药物合成技术领域,具体涉及一种呋塞米的制备方法.所述呋塞米的制备方法包括以下步骤:氯磺化:将氯磺酸和2,4‑二氯苯甲酸反应后水解,过滤,得2,4‑二氯‑5‑磺酰氯苯甲酸;胺化:将2,4‑二氯5‑磺酰氯苯甲酸加入氨水中,反应,中和,过滤,提纯,得2,4‑二氯‑5‑磺酰胺基苯甲酸;缩合:将2‑呋喃甲胺和2,4‑二氯‑5‑磺酰胺基苯甲酸反应,得呋塞米粗品;脱色:将呋塞米粗品加入碳酸氢钠饱和溶液中,再加入活性炭脱色,中和,结晶,即得呋塞米产品.本发明所采用的原料易得且价格低,综合反应周期短,产生的危废量少,制备的呋塞米纯度高,总收率高,整个制备过程综合成本低,适合工业化生产.

专利信息

专利号:US-7427260-B2
优先权日:2001-03-30
标 题:Efficient methods for solid phase synthesis using trityl chloride resins
发明人：PANG YUAN-PING; PARK JEWN GIEW
权利人:MAYO FOUNDATION
摘要:Disclosed are efficient methods for loading amino derivatives onto trityl chloride resins and for cleaving chemically modified amino derivatives from trityl chloride resins. Methods for making a library of discrete chemically modified amino derivatives also disclosed.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.