CAS: 445-27-2; 1-(2-Fluorophenyl)Ethanone

上下游产品

2-Fluorobenzoyl chloride 1-(2-fluorophenyl)ethanol 1-(2-Fluoro-4-trimethylsilanyl-phenyl)-ethanone 1-Fluoro-2-iodobenzene 1-fluoro-2-(1-phenylethenyl)benzene 1-[2'-(pyrrolidin-1''-yl)phenyl]ethan-1-one 1-[2'-(piperidin-1''-yl)phenyl]ethan-1-one 1-[2-(2-Methyl-pyrrolidin-1-yl)-phenyl]-ethanone

1-乙炔基-2-氟苯置于c22H20Aun3O2P(1+)*cf3O3S(1-),水,Silver Trifluoromethanesulfonate,溶剂黄146体系中,化学反应 10.0H,以93%的收率获得产物2'-氟苯乙酮
参考文献:甲基三唑-4-羧酸金(I)配合物的合成及其在丙二烯合成和炔烃水合中的应用
标题:甲基三唑-4-羧酸金(I)配合物的合成及其在丙二烯合成和炔烃水合中的应用
摘要:摘要 开发了含有强吸电子基团的 1H-1,2,3-三唑-4-羧酸甲酯,并将其用作金 (I) 阳离子的配体.研究了所得的酯-三唑金 (I) 配合物在催化丙二烯合成和炔烃水合方面的效率,其中在低催化剂负载下观测到优异的催化效率.
DOI:10.1016/j.Inoche.2019.107564

专利信息

专利号:WO-2022040891-A1
优先权日:2020-08-24
标 题:USE OF DEPROTONATED PHENYL-BRIDGED β-KETIMINE LITHIUM COORDINATION COMPLEX IN CYANOSILICATE REACTION
发明人：XUE MINGQIANG; XU XIAOJUAN; KANG ZIHAN; ZHOU SHUAI; CHEN SUFANG; ZHENG YU
权利人:UNIV SOOCHOW
摘要:The use of deprotonated phenyl-bridged β-ketimine lithium coordination complex in a cyanosilicate reaction is disclosed. In the coordination complex, each β-ketimine unit is a double negative ion. A double negative ion β-ketimine group is a group having very high reactivity and can, for example, react with small molecules containing reactive hydrogen and with unsaturated bonded organic small molecules. The coordination complex may also function as a precursor for further synthesis of a double negative ion β-ketimine rare earth metal coordination complex. Use of the coordination complex in cyanosilicate reaction of a carbonyl group compound allows for the reaction temperature to be room temperature, and allows for highly effective carbonyl group compound and TMSCN reduction within a very short reaction time.

专利号:US-10035796-B2
优先权日:2014-08-14
标题:Crystalline forms of a BACE inhibitor, compositions, and their use
发明人：KAZAKEVICH IRINA; TRZASKA SCOTT; FENG TAO
权利人:MERCK SHARP & DOHME
摘要:The present invention provides a novel synthesis of verubecestat, and two novel crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an Aβ pathology and/or a symptom or symptoms thereof. Non-limiting examples of such Aβ pathologies, including Alzheimer's disease, are disclosed herein.

专利号:WO-2007141253-A1
优先权日:2006-06-07
标 题 :Process for the production of intermediates for the preparation of tricyclic imidazopyridines
发明人：PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO
摘要:The invention relates to a process for the synthesis of compounds of the formula (1-a) and compounds of the formula (1-b). The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Arom have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

专利号:US-8940516-B2
优先权日:2006-12-08
标题:Method for the synthesis of chiral cyanohydrins via a hydroxynitrile lyase from brassicaceae
发明人：EGGERT THORSTEN; ANDEXER JENNIFER
权利人:EVOCATAL GMBH
摘要:The invention concerns a polypeptide which can be isolated from the Brassicaceae family and which has at least the activity of a hydroxynitrile lyase (HNL). The hydroxynitrile lyase of the invention is the first HNL from the Brassicaceae family. The plants ( Arabidopsis ) from which this enzyme or its gene is isolated is also described as non-cyanogenic. All HNL-containing plants described so far are cyanogenic plants and so it has until now been assumed that only cyanogenic plants contain hydroxynitrile lyases. Surprisingly, it transpires that a polypeptide (AtHNL) of the invention is (R)-selective. The amino acid sequence gives a theoretical molecular weight of 29.2 kDa for the AtHNL subunit. The calculated molecular mass of the protein of approximately 30 kDa can be confirmed by SDS gel electrophoresis.

专利号:US-9062085-B2
优先权日:2010-09-10
标 题 :Biaryl diphosphine ligands, intermediates of the same and their use in asymmetric catalysis
发明人：ABDUR-RASHID KAMALUDDIN; JIA WENLI; LU SHUIMING; GUO RONGWEI; CHEN XUANHUA; AMOROSO DINO
权利人:ABDUR-RASHID KAMALUDDIN; JIA WENLI; LU SHUIMING; GUO RONGWEI; CHEN XUANHUA; AMOROSO DINO; KANATA CHEMICAL TECHNOLOGIES INC
摘要:The present disclosure relates to biaryl diphosphine ligands of the formula (B), processes for the production of the ligands and the use of the ligands in metal catalysts for asymmetric synthesis. The disclosure also relates to intermediates used for the production of the biaryl diphosphine ligand. (Formula (B))

专利号:US-2023002426-A1
优先权日:2019-11-15
标题 :Chiral synthesis of a tertiary alcohol