CAS: 53-41-8; Androsterone

该化合物是一种自然产生的类固醇激素和一种芳香素,主要产自睾酮和脱氢酮的新陈代谢,主要在人体中产生,被归类为19诺类类固化,化学配方为C19H28O2,安卓酮的特征是其相对低的威力,而与其他和青蛙相比,它的作用是相对较低的,但它在男性第二性特征的发育中起着一定的作用,并可能影响性欲;该物质通常存在于尿液中,并且经常在临床环境中测量,以评估肾上腺功能或色素水平;安罗酮的熔点因形式和纯度而异,在有机溶剂中溶解,但水溶解度有限;其生物活动通过和受色素的受体进行介介,并且还可能表现出某种致卵性效应;由于其激素的性质,它对于医学研究和体育科学都有兴趣,特别是对其性能和健康的潜在影响.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号846-46-8 5a-雄甾烷二酮 | CAS号1239-31-2 醋酸去氢表雄酮 | CAS号111222-34-5 (3R,5S,8R,9S,10... | CAS号1852-53-5 5a-雄甾烷-3a,17b-二醇 | CAS号10429-07-9 3β-(4-methylphe... | CAS号5717-77-1 (3β,5α)-3-hydro... | CAS号481-29-8 表雄酮 | CAS号897-01-8 Androst-5-en-17... | CAS号58-22-0 睾酮 | CAS号14639-79-3 5α-Androst-2-en... | CAS号14935-81-0 5-雄甾-3-烯-17-酮 | CAS号1852-41-1 androsterone su... | CAS号481-29-8 表雄酮 | CAS号846-46-8 5a-雄甾烷二酮 | CAS号1852-53-5 5a-雄甾烷-3a,17b-二醇 | CAS号1852-43-3 雄酮葡萄糖醛酸 | CAS号66885-58-3 1α,3β-Dihydroxy...

合成工艺路线路线简述

    雄诺龙 反应 1008.0H,反应生成 雄酮
    参考文献:Draczynska,Bozena; Tlomak,Elzbieta; Dmochowska-Gladysz,Jadwiga,Bulletin De L'Academie Polonaise Des Sciences,Serie Des Sciences Chimiques,1982,Vol. 30,# 1-12,P. 13-21
    标题:Draczynska,Bozena; Tlomak,Elzbieta; Dmochowska-Gladysz,Jadwiga,Bulletin De L'Academie Polonaise Des Sciences,Serie Des Sciences Chimiques,1982,Vol. 30,# 1-12,P. 13-21

    海关参考信息

    专利信息


    专利号:US-10768157-B2
    优先权日:2015-10-20
    标 题:Materials and methods for the detection of trace amounts of substances in biological and environmental samples
    发明人:KABIR ABUZAR; FURTON KENNETH G
    权利人:KABIR ABUZAR; FURTON KENNETH G; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
    摘要:The subject invention provides chemical compositions and synthesis strategies to create molecularly imprinted polymers (MIPs) via sol-gel processes. In a specific embodiment, the subject invention utilizes a(n) organic, inorganic, or metallic template analyte to create a hybrid organic-inorganic or inorganic three-dimensional network possessing cavities complementary to the shape, size, and functional orientation of the template molecule or ions. The subject invention further pertains to the use of the novel MIPs as selective solid phase extraction (SPE) sorbents for pre-concentration and clean-up of trace substances in biological and environmental samples. Synthesis of other molecularly imprinted polymers with environmental, pharmaceutical, chemical, clinical, toxicological, and national security implications can be conducted in accordance with the teachings of the subject invention.

    专利号:US-9382288-B2
    优先权日:2010-10-06
    标题 :Derivatives of steroid benzylamines, having an antiparasitic antibacterial, antimycotic and/or antiviral action
    发明人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO
    权利人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO; UNIV GIESSEN JUSTUS LIEBIG
    摘要:The present invention relates to compounds derived from steroids of the general formula (I) n nwherein L represents a linker and R # represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).

    专利号:US-4215044-A
    优先权日:1979-04-23
    标题:Synthesis of α-fluorocarbonyl compounds
    发明人:MIDDLETON WILLIAM J
    权利人:DU PONT
    摘要:Process for preparing an organic compound of the formula R 2 R 2 CFC(O)R 3 , which process comprises contacting and reacting in a reaction mixture which includes an inert solvent, at a temperature of -40° C. to -100° C., ROF and ##STR1## R is polyfluoroperhaloalkyl of 1-6 carbon atoms or FOCF 2 ; R 1 is hydrocarbyl of 1-6 carbon atoms; n each R 2 is selected from H, alkyl of 1-17 carbon atoms, cycloalkyl of 3-6 carbon atoms, aryl, heteroaryl and such alkyl, cycloalkyl, aryl and heteroaryl substituted by halogen or alkoxy of 1-6 carbon atoms; n R 3 is selected from H, alkyl and haloalkyl of 1-16 carbon atoms, cycloalkyl of 3-10 carbon atoms, aryl and haloaryl, OSi(R 1 ) 3 , OH, NH 2 , alkoxy of 1-6 carbon atoms, aryloxy, NHR 1 and NR 1 2 wherein R 1 is alkyl of 1-6 carbon atoms, N-arylamino and nitrogen or sulfur heterocyclic of 4-5 carbon atoms; n R 3 and one R 2 taken together is a diradical which with the Câ•?C group is carbocyclic, heterocyclic or haloheterocyclic, and recovering from the reaction mixture the compound of the formula R 2 R 2 CFC()R 3 .

    专利号:US-11306343-B2
    优先权日:2014-08-12
    标 题:3α-hydroxysteroid dehydrogenase mutants and process for the preparation of ursodeoxycholic acid
    发明人:HUMMEL WERNER; BAKONYI DANIEL
    权利人:PHARMAZELL GMBH
    摘要:The invention provides novel 3α-hydroxysteroid dehydrogenase mutants, sequences that code for these enzyme mutants, methods for producing the enzyme mutants, and the use thereof in enzymatic reactions of cholic acid compounds, and in particular in the production of ursodeoxycholic acid (UDCA). The invention further provides processes for the synthesis of UDCA using the enzyme mutants and the production of UDCA using recombinant microorganisms that have been subjected to multiple modifications.

    专利号:US-6147159-A
    优先权日:1998-09-30
    标 题 :Compositions for organic synthesis on solid phase and methods of using the same
    发明人:HU YONGHAN; LABADIE JEFFREY W; PORCO JR JOHN ANTHONY; TROST BARRY MARTIN
    权利人:ARGONAUT TECHNOLOGIES
    摘要:A modified solid support for use in solid phase synthesis which comprises: a solid support having a linker group extending therefrom having the general formula: wherein R1 and R2 are each independently selected from the group consisting of alkyl, cycloalkyl, aryl, alkoxy, aryloxy, fluorine, chlorine, iodine and bromine.

    专利号:US-9295679-B2
    优先权日:2008-03-25
    标 题:Prodrugs of C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
    发明人:NJAR VINCENT; BRODIE ANGELA; GEDIYA LALJI K
    权利人:UNIV MARYLAND
    摘要:Prodrugs of steroidal C-17 benzoazoles, pyrimidinoazoles (az-abenzoazoles) and diazines. Methods of synthesis are also described, whereby a prodrug group is substituted for a functional group at A ring portion of the ABC ring structure of the steroid. Suitable pro-drug groups include amino acid groups, succinate groups, phosphate groups, or sulfamate groups. The prodrugs of the disclosed compounds allow for improved oral bioavailability of the compounds that are inhibitors of human CYP 17 enzyme as well as potent antagonists of both wild type and mutant androgen receptors (AR). The compounds and the corresponding prodrugs are useful for the treatment of conditions such as human prostate cancer, breast cancer, and prostate hyperplasia.
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    合成参考文献


    参考文献:10.1007/s10549-005-9083-x
    摘要:Trafalis DT, Geromichalos GD, Koukoulitsa C, Papageorgiou A, Karamanakos P, Camoutsis C. Lactandrate: a D-homo-aza-androsterone alkylator in the treatment of breast cancer. Breast Cancer Res Treat. 2006 May;97(1):17–31. doi: 10.1007/s10549-005-9083-x.
    参考文献:10.1016/j.steroids.2011.06.005
    摘要:Mazzarino M, Braganò MC, de la Torre X, Molaioni F, Botrè F. Relevance of the selective oestrogen receptor modulators tamoxifen, toremifene and clomiphene in doping field: endogenous steroids urinary profile after multiple oral doses. Steroids. 2011 Nov;76(12):1400–6. doi: 10.1016/j.steroids.2011.06.005.
    参考文献:10.1186/1471-2164-12-362
    摘要:Grindflek E, Lien S, Hamland H, Hansen MH, Kent M, van Son M, Meuwissen TH. Large scale genome-wide association and LDLA mapping study identifies QTLs for boar taint and related sex steroids. BMC Genomics. 2011 Jul 13;12():362.
    参考文献:10.1016/j.chroma.2011.06.014
    摘要:Kioussi MK, Angelis YS, Cawley AT, Koupparis M, Kazlauskas R, Brenna JT, Georgakopoulos CG. External calibration in gas chromatography-combustion-isotope ratio mass spectrometry measurements of endogenous androgenic anabolic steroids in sports doping control. J Chromatogr A. 2011 Aug 19;1218(33):5675–82. doi: 10.1016/j.chroma.2011.06.014.
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