CAS: 6303-18-0; Pentane-1-Sulfonyl Chloride

该化合物是一种有机化合物,其特点是存在附于五角形链的全氟辛烷磺酸功能组;一种一般用作有机合成试剂的无色和淡黄色液体,特别是用于制作磺酰胺和其他磺酰衍生物的试剂;该化合物以其反应性而著称,特别是在核生殖性替代反应中,它可以分别与胺和酒精发生反应以形成磺酰胺和磺酸盐;Pentane-1-sultony 氯化物也具有湿性,这意味着它能够吸收空气中的湿度,从而影响其稳定性和再活性;由于存在硫化物组,该化合物被认为是具有腐蚀性,应当谨慎处理,使用适当的安全措施,例如手套和子;其应用范围扩大到各个领域,包括药物和农用化学物,它作为合成更复杂的分子的重要建筑块.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

diamyl disulfide n-pentanethiol n-pentyl thi°Cyanate 1-pentanesulfonic acidperfluoro-n-pentane sulfonylfluoride methyl 1-pentanesulfonate Pentan-sulfonsaeure-p-tolylester 1-pentylsulfonamide

合成工艺路线路线简述

    二戊基二硫醚置于氯,溶剂黄146体系中,化学反应生成 戊烷-1-磺酰氯
    参考文献:Lee; Dougherty,Journal Of Organic Chemistry,1940,Vol. 5,P. 84
    标题:Lee; Dougherty,Journal Of Organic Chemistry,1940,Vol. 5,P. 84

    海关参考信息

    专利信息


    专利号:US-10995049-B2
    优先权日:2019-07-19
    标 题 :Total synthesis of prostaglandin J natural products and their intermediates
    发明人:LI JIAMING; XU CHEN; AHMED TONIA S; GRUBBS ROBERT H; STOLTZ BRIAN M
    权利人:CALIFORNIA INST OF TECHN
    摘要:The present disclosure is directed to methods of preparing prostaglandin J natural products by stereoretentive metatheses reactions and intermediates used in the synthesis of these natural products, including the use of intermediates of Formula (I-A), where R 1 is defined in the specification

    专利号:US-7420052-B2
    优先权日:2001-08-24
    标 题:Intermediates for synthesis of vinblastine, process for preparation of the intermediates and process for synthesis of vinblastines
    发明人:FUKUYAMA TOHRU; TOKUYAMA HIDETOSHI; YOKOSHIMA SATOSHI
    权利人:JAPAN SCIENCE & TECH AGENCY
    摘要:An intermediate for vinblastine synthesis represented by general formula A. n ngeneral formula A.n n(in the formula, R 1 , R 2 , R 3 and R 4 are the group selected independently from the group consisting of H, lower alkyl group, lower alkoxy group, halogen, lower perfluoroalkyl group, lower alkylthio group, hydroxy group, amino group, mono- or di-alkyl or acylamino group, lower alkyl or arylsulfonyloxy group. R 5 is H, or a lower alkyl group or a substituted or non-substituted aryl group, R 6 is an alkyl group of carbon number 4 or less, R 7 is a substituted or non-substituted aryl group, R 8 is a substituted or non-substituted aryl group or lower alkyl group and R 9 is an acyl group or trialkylsilyl group.) A method for synthesis of the compound of general formula A utilizing radical ring forming reaction of thioanilides and using the compound of general formula B as the starting material, synthesizing thioanilide of general formula C by the reaction with compound 1 and the formation of a 11-membered ring by intramolecular alkylation of 2-nitrobenzenesulfonamide by which the reactions can proceed under mild conditions and high yield can be accomplished.

    专利号:US-9988364-B1
    优先权日:2017-03-21
    标题 :Process for synthesis of Eliglustat and intermediate compounds thereof
    发明人:LIU YU; YU GUANNENG; ZHENG ZHIGUO
    权利人:ZHEJIANG AUSUN PHARMACEUTICAL CO LTD
    摘要:The present invention relates to a process for synthesis of Eliglustat and intermediate compounds thereof. In particular, the present invention relates to a process for synthesis of Eliglustat and pharmaceutically acceptable salts thereof, and relates to the intermediate compounds in the process and a process for preparation of the intermediate compounds.

    专利号:US-6849743-B2
    优先权日:1997-08-15
    标 题 :Synthesis of clasto-lactacystin β-lactone and analogs thereof
    发明人:SOUCY FRANCOIS; FLAMONDON LOUIS; BEHNKE MARK; ROUSH WILLIAM
    权利人:MILLENNIUM PHARM INC
    摘要:The present invention is directed to an improved synthesis of clasto-lactacystin-β-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel stereospecific synthesis of an oxazoline intermediate and a unique stereoselective addition of a formyl amide to the oxazoline. Also described are novel clasto-lactacystin-β-lactones, and analogs thereof and their use as proteasome inhibitors.

    专利号:US-2003083352-A1
    优先权日:2000-07-31
    标 题 :Synthesis of imidazole intermediates
    发明人:HELAL CHRISTOPHER J
    权利人:PFIZER
    摘要:The invention provides a method for synthesis of compounds of formula n n n wherein R 1 and R 19 are as defined. Compounds of formula 12 are useful as intermediates for synthesizing compounds having pharmacological activity inhibiting cdk5, cdk2, and GSK-3.

    专利号:US-2013338369-A1
    优先权日:2011-03-07
    标 题 :Process for the Synthesis of Aminobiphenylene
    发明人:HEINRICH MARKUS; PRATSCH GERALD
    权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE
    摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.
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    合成参考文献


    参考文献:10.1007/10680373_10
    摘要:Dykyj J, Svoboda J, Wilhoit RC, Frenkel M, Hall KR. 3 Sulfur Containing Organic Compounds, C5 to C89. 1999. In: Vapor Pressure and Antoine Constants for Hydrocarbons, and S, Se, Te, and Halogen Containing Organic Compounds. : Springer-Verlag; 1999.
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