CAS: 10406-25-4; 4-(Aminomethyl)Benzonitrile

相似化合物

66389-80-8 56-91-7 20188-40-3

上下游产品

CAS号84466-87-5 4-Cyanobenzyl a... | CAS号623-26-7 对苯二甲腈 | CAS号17201-43-3 α-溴对甲基苯甲腈 | CAS号172348-74-2 N,N-二-b°C-4-氨基甲基苯甲腈 | CAS号2627-86-3 (S)-(-)-α-甲基苄胺 | CAS号105-07-7 对氰基苯甲醛 | CAS号873-74-5 对氨基苯腈 | CAS号104-85-8 对甲苯腈 | CAS号874-86-2 4-氰基苄氯 | CAS号32797-61-8 4-氨甲基苄眯二盐酸盐 | CAS号369-53-9 4-(氨基甲基)苯甲酰胺 | CAS号220648-78-2 N-[[4-[(羟基氨基)亚氨... | CAS号21388-95-4 (4-cyanophenyl)... | CAS号874-86-2 4-氰基苄氯 | CAS号874-89-5 羟甲基 | CAS号539-48-0 1,4-苯二甲胺 | CAS号108468-00-4 1-(N-B°C-氨基甲基)-... | CAS号56-91-7 氨甲苯酸 | CAS号328552-93-8 4-氨基甲基-N-羟基苯甲脒

对苯二腈置于二氧化碳,Rh/al2O3,氢气体系中,化学反应 6.0H,以94.2%的收率获得对氰基苄胺
参考文献:在超临界二氧化碳中由二硝基苯到二甲腈的高效加氢
标题:在超临界二氧化碳中由二硝基苯到二甲腈的高效加氢
摘要:己二腈的高选择性加氢在超临界二氧化碳(scco 2)中有效地进行,以生成6-氨基己腈,相对于铑/氧化铝(rh / Al 2 O 3)具有100%的优异选择性,并且没有任何添加剂,这在传统有机溶剂中是不可能的溶剂.Co 2的存在对于氨基腈的排他形成可能是有益的或强制性的,因为它可以充当溶剂来增强活性,也可以作为临时保护剂来提高选择性.这些结果成功显示了使用scco 2的一般概念作为选择性控制二腈对氨基腈反应的保护性介质.还研究了催化剂的再循环以及该方法进一步扩展到其他二腈的方法.
Doi:10.1002/adsc.201000514

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:WO-0001691-A1
优先权日:1998-07-01
标 题 :Process for making farnesyl-protein transferase inhibitors
发明人：ASKIN DAVID; COWEN JENNIFER A; MALIGRES PETER E; MCWILLIAMS J CHRISTOPHER; MCCAULEY JAMES A
权利人:MERCK & CO INC; ASKIN DAVID; COWEN JENNIFER A; MALIGRES PETER E; MCWILLIAMS J CHRISTOPHER; MCCAULEY JAMES A
摘要:The present invention is directed to the improved synthesis of compounds of formula (I): which may be useful as farnesyl-protein transferase inhibitors. The present invention is also directed to the crystal forms of the monohydrate and mon-hydrochloride salt of 1-(3-Chlorophenyl)-4-[1-(4-cyanobenzyl)-5-imidazolylmethyl]-2-piperazinone.

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:CN-113636931-B
优先权日:2021-08-05
标题:Starting head fragment compound of genetically encoded compound library and its application in the synthesis of genetically encoded compound library

专利号:TW-I510627-B
优先权日:2012-08-20
标题:Large-scale enzyme synthesis of oligosaccharides

专利号:TW-I573876-B
优先权日:2012-08-20
标 题 :Large-scale enzyme synthesis of oligosaccharides