CAS: 114772-53-1; 4'-Methyl-[1,1'-Biphenyl]-2-Carbonitrile

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CAS号873-32-5 邻氯苯腈 | CAS号5720-05-8 对甲基苯基硼酸 | CAS号2042-37-7 邻溴苯腈 | CAS号4294-57-9 甲苯基硼化镁 | CAS号106-38-7 对溴甲苯 | CAS号214360-47-1 2-腈基苯硼酸新戊二醇酯 | CAS号696-61-7 对甲苯基氯化镁 | CAS号209911-63-7 4-(二溴甲基)-[1,1-联... | CAS号114772-54-2 4'-溴甲基-2-氰基联苯 | CAS号3839-22-3 2-氰基苯甲酸 | CAS号7148-03-0 2-(对甲苯基)苯甲酸 | CAS号133690-92-3 4'-氨甲基-2-氰基联苯 | CAS号120568-11-8 5-[2-(4'-甲基联苯基)]四唑 | CAS号209911-63-7 4-(二溴甲基)-[1,1-联... | CAS号114772-54-2 4'-溴甲基-2-氰基联苯 | CAS号114772-38-2 2-[4-(溴甲基)苯基]苯甲酸甲酯 | CAS号114772-34-8 2-(对甲苯基)苯甲酸甲酯 | CAS号124750-99-8 氯沙坦钾 | CAS号133051-88-4 5-[4'-(溴甲基)-1,1... | CAS号114772-40-6 4'-溴甲基联苯-2-甲酸叔丁酯

邻甲氧基苯甲酸置于吡啶,氯化亚砜,Magnesium,三氯氧磷体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 6.0H,反应生成2-氰基-4'-甲基联苯
参考文献:苯并咪唑及其衍生物抗高血压药的合成,表征及生物学评价
标题:苯并咪唑及其衍生物抗高血压药的合成,表征及生物学评价
摘要:一种取代的苯并咪唑和苯并噻唑衍生物已被合成,并通过拮抗血管紧张素ii(ang Ii)受体展现了抗高血压活性.该化合物的体内抗高血压活性是在急性肾高血压模型中进行的.两种化合物tg 1和tg 3的抗高血压活性与血管紧张素ii受体拮抗剂类药物的原型--替米沙坦相当.在抗高血压研究中,化合物tg 1,Tg 2和tg 3的收缩压分别为147.2 Mm/hg,168.2 Mm/hg和126.3 Mm/hg.这些收缩压低于疾病对照车辆处理的啮齿动物,其收缩压为167.2 Mm/hg.舒张压分别为119.7 Mm/hg,124.7 Mm/hg和88.83 Mm/hg,而疾病对照车辆处理的啮齿动物的舒张压为122.3 Mm/hg.Tg 3在平均动脉血压(mabp)下降方面与替米沙坦相当.这些令人鼓舞的结果使tg 3成为有效的抗高血压药物候选者,值得进一步研究.
Doi:10.21608/ejchem.2021.79840.3931

专利信息

专利号:US-11485721-B2
优先权日:2017-11-21
标 题:Method for the metal-free preparation of a biaryl by a photosplicing reaction and their uses
发明人：KLOSS FLORIAN; NEUWIRTH TONI; HAENSCH VEIT; HERTWECK CHRISTIAN
权利人:LEIBNIZ INST FUER NATURSTOFF FORSCHUNG UND INFEKTIONSBIOLOGIE E V HANS KNOELL INST HKI; LEIBNIZ INST FUER NATURSTOFF FORSCHUNG UND INFEKTIONSBIOLOGIE E V HANS KNOELL INST
摘要:The present invention relates to a method for the metal-free preparation of a biaryl compound by a photosplicing reaction and its use in the preparation of chemical compounds, preferably of active ingredients e.g. in the fields of pharmaceuticals and agrochemicals. In particular, it refers to a method for the regiocontrolled preparation of a biaryl compound of formula (I): Ar—Ar′ by photochemically reacting a precursor compound of formula (II): Ar—L—Ar′ to form a biaryl compound of general formula: Ar—L—Ar′(II)→Ar—Ar′ (I) wherein Ar and Ar′, independently of each other, represent an unsubstituted or substituted C6-C20 aryl group or a heteroaryl group with 5-20 ring atoms selected from carbon, nitrogen, oxygen and sulfur, and L represents a group —X—Y—Z— as defined herein. The biaryl compounds are generally suitable as intermediates or key building blocks in a very broad spectrum of organic chemical syntheses and their respective utilities. Their use within the field of synthesis of active ingredients is an aspect of the invention, and their use in the preparation of pharmaceutically active ingredients is particularly preferred.

专利号:US-6326498-B1
优先权日:2001-03-13
标 题 :Process for the synthesis of 5-(2-flurophenyl)-1H-tetrazole
发明人：MALLADI PARDHASARADHI; KANTEVARI SRINIVAS; NAIR CHEMBUMKULAM KAMALAKSHYAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses a process of the preparation of 5-(2-flurophenyl)-1H-tetrazole of the formula 2 by reacting 2-fluoro benzonitrile of the formula 1 n with an inorganic azide and an amine salt in an aromatic solvent, precipitating the product with hydrochloric acid and separating the precipitated product.

专利号:WO-2008012852-A1
优先权日:2006-07-27
标 题:Intermediate compounds for the preparation of angiotensin ii antagonists
发明人：GUANDALINI LUCA; MARTINI ELISABETTA; ROMANELLI MARIA NOVELLA; DALLATOMASINA FRANCO
权利人:S I M S S R L SOC IT MEDICINAL; GUANDALINI LUCA; MARTINI ELISABETTA; ROMANELLI MARIA NOVELLA; DALLATOMASINA FRANCO
摘要:The present invention relates to novel substituted biphenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists, to a process for the synthesis of them and to a process for the conversion thereof to said molecules.

专利号:WO-9637481-A1
优先权日:1995-05-26
标题:Novel reagent for tetrazole synthesis and process for producing tetrazoles therewith
发明人：TOKUHARA GINRO; YAMAGUCHI TADASHI; IWASAKI TETSUYA
权利人:CHUGOKU KAYAKU; WAKUNAGA SEIYAKU KK; TOKUHARA GINRO; YAMAGUCHI TADASHI; IWASAKI TETSUYA
摘要:A process for producing 1H-tetrazoles represented by general formula (II) (wherein R represents an arbitrary substituent) from carbonitriles represented by the general formula (I): R-CN (wherein R is as defined above) with the use of a tetrazolating agent comprising an alkali metal azide and zinc chloride. The agent can be used in a variety of solvents and can fundamentally be applied to any carbonitriles. As zinc chloride is inexpensive, it contributes to cost reduction.

专利号:US-6417400-B1
优先权日:1998-03-24
标题:Methyl-phenyl derivatives, preparation method and use
发明人：DORMOY JEAN-ROBERT; GOUBET DOMINIQUE; MOREAU PATRICE
权利人:SANOFI SYNTHELABO
摘要:The present invention relates to:a) methylbiphenyl derivatives of general formula:in which R1 represents OH, C3-C7 alkyl or C3-C7 cycloalkyl, these compounds being in the form of individual isomers or mixtures thereof,b) their preparation by reaction:either of a hydroxylamine salt with an N-substituted o-(p-tolyl)benzaldimine, to give o-(p-tolyl)benzaldoximeor of an N-substituted 2-halobenzaldimine with a p-tolylmagnesium halide in the presence of an inorganic manganese derivative, to give the compounds of formula I in which R1 represents C3-C7 alkyl or C3-C7 cycloalkylc) their use for the preparation of o-(p-tolyl)-benzonitrile, which is an intermediate in the synthesis of medicinal products.

专利号:US-7968727-B2
优先权日:2005-04-01
标 题 :Synthesis of 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl and its use in preparation of angiotensin II antagonists
发明人：COPAR ANTON; ANTONCIC LJUBOMIR; ANTONCIC MATEJ
权利人:LEK PHARMACEUTICALS
摘要:4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl are useful starting material for the preparation various angiotenzin II antagonists, which are prepared from 4-bromomethyl-2′-cyanobiphenyl or 4′-bromomethylbiphenylcarboxyilic derivatives using selected hydride reagent.