CAS: 1378388-16-9; (2S,4S)-1-(Tert-Butoxycarbonyl)-4-(Methoxymethyl)Pyrrolidine-2-Carboxylic Acid

相似化合物

2167945-77-7 2514752-91-9 2518116-06-6

上下游产品

(2S,4S)-N-Tert-Butoxycarbonyl-2-Carboxyl-4-Hydroxymethylpyrrolidine 1643468-66-9
(2S,4S)-1-叔丁基2-甲基4-(甲氧基甲基)吡咯烷-1,2-二羧酸 (2S,4S)-1-Tert-Butyl 2-Methyl 4-(Methoxymethyl)Pyrrolidine-1,2-Dicarboxylate 1378388-37-4
(2S,4S)-1-叔丁基-2-甲基-4-(羟基甲基)吡咯烷-1,2-二羧酸 (2S,4S)-1-Tert-Butyl 2-Methyl 4-(Hydroxymethyl)Pyrrolidine-1,2-Dicarboxylate 1194059-42-1
(2S,4S)-1-叔丁基2,4-二甲基吡咯烷-1,2,4-三羧酸酯 (2S,4S)-1-Tert-Butyl 2,4-Dimethyl Pyrrolidine-1,2,4-Tricarboxylate 1378388-30-7
Velpatasvir中间体 (3S,5S)-1-(Tert-Butoxycarbonyl)-5-(Methoxycarbonyl)Pyrrolidine-3-Carboxylic Acid 1378388-35-2
(2S,4S)-N-Tert-Butoxycarbonyl-2-Tert-Butoxycarbonyl-4-Carboxyl Pyrrolidine 686766-82-5
顺式-N-Boc-4-氰基-L-脯氨酸甲酯 (2S,4S)-1-Tert-Butyl 2-Methyl 4-Cyanopyrrolidine-1,2-Dicarboxylate 487048-28-2
Boc-L-羟脯氨酸 (2S,4R)-4-Hydroxy-1-[(2-Methylpropan-2-yl)Oxycarbonyl]Pyrrolidine-2-Carboxylic Acid 13726-69-7 1-Tert-Butyl 2-Methyl (2S,4R)-4-Hydroxy-1,2-Pyrrolidinedicarboxylate 74844-91-0 (S)-1-Tert-Butyl 2-Methyl 4-Oxopyrrolidine-1,2-Dicarboxylate 102195-80-2

(2S,4S)-N-Tert-Butoxycarbonyl-2-Tert-Butoxycarbonyl-4-Carboxyl Pyrrolidine置于盐酸,Sodium Tetrahydroborate,水,三乙胺,Sodium Hydroxide体系中,用 四氢呋喃,乙醇,二氯甲烷 用作溶剂,化学反应 13.0H,反应生成(2S,4S)-1-(叔丁氧羰基)-4-(甲氧甲基)吡咯啉-2-羧酸
参考文献:Preparation Method For Pyrrolidine-2-Carboxylic Acid Derivatives
标题:Preparation Method For Pyrrolidine-2-Carboxylic Acid Derivatives
摘要:本发明涉及医药合成领域,特别是一种吡咯烷-2-羧酸衍生物的制备方法.本发明采用以下技术方案:提供具有结构式(e)的化合物,其中r为r1或r2,R1为c1-C6烷基,苄基,对甲氧基苄基或对硝基苄基,R2为氢;R3为羧基的保护基;P1为氮上的保护基.

专利信息

专利号:US-9902693-B2
优先权日:2013-06-26
标 题 :Preparation method for pyrrolidine-2-carboxylic acid derivatives
发明人：ZHANG BIN; LI YUANQIANG; CHE DAQING; QIAN LINGFENG; ZHU GUOLIANG; YE WENFA
权利人:ZHEJIANG JIUZHOU PHARM CO LTD
摘要:The present invention relates to the field of medical synthesis, in particular to a preparation method for pyrrolidine-2-carboxylic acid derivatives. The present invention adopts the following technical solution: providing a compound having a structure of formula (E), wherein R is R 1 or R 2 , R 1 is C 1 -C 6 an alkyl, benzyl, p-methoxybenzyl, or p-nitrobenzyl group, and R 2 is hydrogen; R 3 is a protecting group of the carboxyl group; and P 1 is a protecting group on nitrogen.

专利号:CN-105801462-A
优先权日:2014-12-29
标 题 :Synthesis method of (4S) -N-Boc-4-methoxymethyl-L-proline