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CAS号623-49-4 氰基甲酸乙酯 | CAS号617-36-7 草酸酰胺乙酯 | CAS号19172-47-5 劳森试剂 | CAS号144-55-8 碳酸氢钠 | CAS号1050507-06-6 4-(2-氯苯基)-2-噻唑羧酸乙酯 | CAS号58334-08-0 5-甲基-噻唑-2-羧酸乙酯 | CAS号911466-96-1 2-(乙氧基羰基)噻唑-4-羧酸 | CAS号31877-30-2 4-苯基噻唑-2-甲酸乙酯 | CAS号960235-24-9 5-(溴甲基)噻唑-2-羧酸乙酯 | CAS号886366-42-3 4-(4-甲氧基苯基)噻唑-2-羧酸乙酯 | CAS号79247-86-2 4-三氟甲基噻唑-2-甲酸乙酯 | CAS号75680-91-0 4-(4-氯苯基)噻唑-2-甲酸乙酯 | CAS号53101-02-3 4-(4-溴苯基)噻唑-2-甲酸乙酯 | CAS号53101-04-5 4-(4-硝基苯基)噻唑-2-甲酸乙酯

氰基甲酸乙酯置于硫化氢体系中,用 甲苯 用作溶剂,化学反应生成硫代草氨酸乙酯
参考文献:硫代酰胺酸钾的晶体结构和振动光谱
标题:硫代酰胺酸钾的晶体结构和振动光谱
摘要:标题化合物 K-So2Nc2H2,Mr=143.21,(1) 的晶体和分子结构测定是 N-取代硫代酰胺酸盐系列测定的一部分.使用在 295 K [mokα 辐射,λ=0.71073 å] 下测量的单晶 X 射线衍射数据对结构进行了改进.晶体为正交晶系,空间群 Pn2La,Z=8,晶胞尺寸:A=11.399(2) å,B=22.131(2) å,C=4.021(1) å,V=1014.5(7) å3.Dcalc .=1.875 Mg M-3,Dobs=1.600 Mg M-3,F(000)=576,μ=13.14 Cm-1.1979 年观测到的反射 [i>3σ(I)] 的最终一致性因子为:R=0.062 和 Rw=0.067.振动光谱证实了两个硫代草酰胺分子之间的几何差异.
Doi:10.1007/bf01666104

专利信息

专利号:US-2002058286-A1
优先权日:1999-02-24
标 题 :Synthesis of epothilones, intermediates thereto and analogues thereof
发明人：DANISHEFSKY SAMUEL J; STACHEL SHAWN J; LEE CHUL BOM; CHAPPELL MARK D; CHOU TING-CHAO; WU ZHICAI
摘要:The present invention provides convergent processes for preparing epothilones, desoxyepothilones, and analogues thereof. The present invention further provides novel compositions and methods for the treatment of cancer and additionally provides methods for the treatment of cancer which has developed a multi-drug phenotype.

专利号:US-6867305-B2
优先权日:1996-12-03
标题:Synthesis of epothilones, intermediates thereto and analogues thereof
发明人：DANISHEFSKY SAMUEL J; STACHEL SHAWN J; LEE CHUL BOM; CHAPPELL MARK D; WU ZHICAL
权利人:SLOAN KETTERING INST CANCER; UNIV COLUMBIA
摘要:The present invention provides convergent processes for preparing epothilones, desoxyepothilones, and analogues thereof. The present invention further provides novel compositions and methods for the treatment of cancer and additionally provides methods for the treatment of cancer which has developed a multi-drug phenotype.

专利号:US-8257931-B2
优先权日:2005-01-21
标题 :Regulation of protein synthesis
发明人：WAGNER GERHARD; CHOREV MICHAEL; MOERKE NATHAN JOHN; AKTAS BERTAL HUSEYIN; HALPERIN JOSE
权利人:WAGNER GERHARD; CHOREV MICHAEL; MOERKE NATHAN JOHN; AKTAS BERTAL HUSEYIN; HALPERIN JOSE; HARVARD COLLEGE
摘要:A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins.

专利号:US-9708336-B2
优先权日:2014-01-22
标题 :Metallo-beta-lactamase inhibitors
发明人：MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

专利号:EP-1259490-A2
优先权日:2000-03-01
标题:Synthesis of epothilones, intermediates thereto and analogues thereof

专利号:US-2002058817-A1
优先权日:1996-12-03
标题 :Synthesis of epothilones, intermediates thereto and analogues thereof