CAS: 21663-61-6; 2,5-Dichlorobenzonitrile

上下游产品

CAS号1435-50-3 2-溴-1,4-二氯苯 | CAS号19398-61-9 2,5-二氯甲苯 | CAS号95-82-9 2,5-二氯苯胺 | CAS号55877-79-7 5-氯-2-甲氧基苯甲腈 | CAS号50-79-3 2,5-二氯苯甲酸 | CAS号2476-37-1 2,5-二氯苯乙酮 | CAS号68534-33-8 5-chloro-2-(3-h... | CAS号68534-34-9 [3-(4-chloro-2-... | CAS号68534-35-0 [2-chloro-5-(4-... | CAS号68534-36-1 5-chloro-2-(4-c... | CAS号99902-89-3 5-chloro-2-(3,4... | CAS号449758-31-0 5-氯-2-(1H-1,2,4... | CAS号629655-19-2 5-CHLORO-2-(1H-...

2-溴-1,4-二氯苯置于magnesium,N,N-二甲基甲酰胺,氨,碘体系中,用 四氢呋喃,水 用作溶剂,化学反应 6.0H,以72%的收率获得2,5-二氯苯甲腈
参考文献:实用的一锅法将芳基溴化物和β-溴苯乙烯转化为芳族腈和肉桂腈
标题:实用的一锅法将芳基溴化物和β-溴苯乙烯转化为芳族腈和肉桂腈
摘要:通过用mg车削和随后的dmf处理,然后用分子碘和nh 3水溶液处理,各种芳基溴化物以非常好的收率有效地转化为相应的芳族腈.相同的处理芳基溴化物,其是弱反应到mg屑,与我prmgcl.licl并随后dmf,接着用分子碘治疗和水溶液nh 3也得到相应的芳香腈以非常好的收率.另一方面,当使用n-甲酰基哌啶代替dmf时,对位取代的β-溴苯乙烯被转化为相应的对位取代的肉桂腈,即α,β-不饱和腈,通过相同的方法具有非常好至中等的收率.该反应通过简单的实验程序进行,不需要任何有毒的金属氰化物或昂贵的稀有金属.因此,本反应是实用的,对环境有益的一锅法,可通过形成格氏试剂及其dmf或dmf分别由芳基溴化物,β-溴苯乙烯和烷基溴化物制备芳族腈,肉桂腈和脂族​​腈.N-甲酰基哌啶加合物.
Doi:10.1016/j.Tet.2012.12.022

专利信息

专利号:US-4536599-A
优先权日:1978-08-22
标题:Synthesis of amine derivatives
发明人：MASUKO FUJIO; KATSURA TADASHI
权利人:SUMITOMO CHEMICAL CO
摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.

专利号:EP-0008532-A1
优先权日:1978-08-22
标 题 :Synthesis of amines

专利号:EP-0008532-B1
优先权日:1978-08-22
标 题 :Synthesis of amines

专利号:EP-0040896-A2
优先权日:1978-08-22
标 题 :Synthesis of amides

专利号:CN-106905525-B
优先权日:2017-03-24
标 题 :A kind of polyaryl ether ketone containing nitrile group and perfluorocyclobutyl aryl ether structure and synthesis method thereof

专利号:CN-106947075-A
优先权日:2017-03-24
标 题:A kind of polyaryletherketone cable material resin and its synthesis method