CAS: 2924-15-4; (2-Fluorophenyl)Hydrazine Hydrochloride

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CAS号348-54-9 邻氟苯胺 | CAS号1057260-27-1 7-氟-1H-吲哚-3-乙醇 | CAS号135108-48-4 5-氨基-1-(2-氟苯基)-... | CAS号3296-04-6 1-Azido-2-fluor... | CAS号177858-77-4 6-Fluoro-2,3,4,... | CAS号866208-25-5 7-FLUORO-3,3-DI...

2-氟苯胺置于盐酸,Sodium Nitrite,Tin(Ll) Chloride体系中,用 水 用作溶剂,化学反应生成2-氟苯肼盐酸盐
参考文献:作为琥珀酸脱氢酶抑制剂的新型氨基环丁烷甲酸衍生物的发现
标题:作为琥珀酸脱氢酶抑制剂的新型氨基环丁烷甲酸衍生物的发现
摘要:构象限制开关概念已被采用作为药物结构优化的主要工具,以扩大化学结构范围并提高针对特定蛋白质的治疗活性.与阳性对照啶酰菌胺相比,以此方式生产的几种1-氨基环丁烷甲酸衍生物在体外表现出令人满意的抗真菌活性.体外抗真菌试验表明,化合物a21对立枯丝核菌( R.S.,Ec 50 = 0.03 Mg/l)和灰葡萄孢( B.C.,Ec 50 = 0.04 Mg/l)具有相当甚至更高的抗真菌活性.Fluxapyroxad(r.S.,Ec 50 = 0.02 Mg/l;B.C.,Ec 50 = 0.20 Mg/l)和啶酰菌胺(r.S.,Ec 50 = 0.29 Mg/ L;B.C.,Ec )50 = 0.42 毫克/升).此外,成功筛选到的化合物a20对猪sdh具有非常好的抑制活性,其ic 50值为3.73 μm,与fluxapyroxad(ic 50 = 3.76 μm)相比具有相当的药效.使用 Sem
Doi:10.1021/acs.Jafc.3C01429

专利信息

专利号:US-11040938-B2
优先权日:2016-07-27
标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts
发明人：MA BING; PAN SHUAI
权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH
摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

专利号:US-8283476-B2
优先权日:2007-06-26
标 题:Transition metal catalyzed synthesis of 2H-indazoles
发明人：HALLAND NIS; NAZARE MARC; LINDENSCHMIDT ANDREAS; ALONSO JORGE; RKYEK OMAR; URMANN MATTHIAS
权利人:HALLAND NIS; NAZARE MARC; LINDENSCHMIDT ANDREAS; ALONSO JORGE; RKYEK OMAR; URMANN MATTHIAS; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct transition metal catalyzed process to a wide variety of multifunctional 2H-indazoles or 2H-azaindazoles of the formula (I) from 2-halo-phenylacetylenes or (2-sulfonato)phenylacetylenes and monosubstituted hydrazines.

专利号:US-2010234601-A1
优先权日:2007-06-26
标 题 :Transition metal catalyzed synthesis of 2H-indazoles

专利号:WO-2009000411-A1
优先权日:2007-06-26
标 题 :A transition metal catalyzed synthesis of 2h-indazoles

专利号:AU-2008267442-A1
优先权日:2007-06-26
标题 :A transition metal catalyzed synthesis of 2H-indazoles

专利号:EP-2170833-A1
优先权日:2007-06-26
标 题 :A transition metal catalyzed synthesis of 2h-indazoles