CAS: 431-35-6; 3-Bromo-1,1,1-Trifluoroacetone

上下游产品

CAS号421-50-1 1,1,1-三氟丙酮(TFK) | CAS号4544-43-8 2-溴-3-氧代-4,4,4-... | CAS号35629-71-1 2-氨基-4-三氟甲基噁唑 | CAS号349-49-5 2-氨基-4-三氟甲基噻唑 | CAS号33468-69-8 4-(三氟甲基)-1H-咪唑 | CAS号927880-90-8 RAF265 | CAS号684-16-2 六氟丙酮 | CAS号73221-12-2 2-(三氟甲基)咪唑并[1,2-a]吡啶 | CAS号133311-65-6 1,1,1-trifluoro... | CAS号127183-53-3 1,1,1-trifluoro... | CAS号109113-96-4 2-三氟甲基咪唑并[1,2-A]吡嗪 | CAS号117341-57-8 3-溴-1,1,1-三氟乙酮肟

2-溴-3-氧代-4,4,4-三氟丁酸乙酯 反应生成 3-溴-1,1,1-三氟丙酮
参考文献:进行酯交换和酯交换.亚磷酸三乙酯和一溴代酯,三磷酸一氯代一酯和单溴代酯的总反应
标题:进行酯交换和酯交换.亚磷酸三乙酯和一溴代酯,三磷酸一氯代一酯和单溴代酯的总反应
摘要:1,1,1-三氟-3-溴丙酮已通过新的简单方法制备:三氟乙酰乙酸乙酯的溴化反应反应生成α-一溴衍生物,并将该酮酯在50%氢溴酸中的十六烷值分解.
DOI:10.1002/hlca.19650480623

专利信息

专利号:US-6136984-A
优先权日:1996-04-22
标 题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest is disclosed. The thiophenes are prepared by acylation of a substrate-bound primary or secondary amine with cyanoacetic acid and reaction of the resulting cyanoacetamide with an isothiocyanate in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegier-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:US-5128485-A
优先权日:1990-12-17
标 题:Synthesis of 2-aryl-5-(trifluoromethyl)pyrroles useful as pesticidal agents and as intermediates for the preparation of said agents
发明人：KAMESWARAN VENKATARAMAN
权利人:AMERICAN CYANAMID CO
摘要:There is provided a synthesis of 2-aryl-5-(trifluoromethyl)pyrrole compounds of formula I via the condensation of a suitable enamine with an alpha -haloketone. 2

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-7897762-B2
优先权日:2006-09-14
标 题:Kinase inhibitors useful for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:DECIPHERA PHARMACEUTICALS LLC
摘要:The present invention relates to novel kinase inhibitors and modulator compounds useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-5352587-A
优先权日:1989-06-23
标 题:Compositions and methods for the synthesis of natriuretic protein receptor B and methods of use
发明人：CHANG MING-SHI; GOEDDEL DAVID V; LOWE DAVID G
权利人:GENENTECH INC
摘要:PCT No. PCT/US90/03586 Sec. 371 Date Dec. 19, 1991 Sec. 102(e) Date Dec. 19, 1991 PCT Filed Jun. 22, 1990 PCT Pub. No. WO91/00292 PCT Pub. Date Jan. 10, 1991.Described are the amino acid sequence of natriuretic peptide receptor B (NPRB) and DNA encoding NPRB. Also disclosed are expression vectors and cells transformed to express the NPRB, DNA encoding NPRB and diagnostic and therapeutic uses for the NPRB and the DNA encoding NPRB.