CAS: 100-68-5; Methylphenylsulfide

相似化合物

623-13-2 622-38-8 1122-97-0

上下游产品

CAS号108-98-5 硫酚 | CAS号616-38-6 碳酸二甲酯 | CAS号1193-82-4 苯亚砜甲酯 | CAS号79-20-9 乙酸甲酯 | CAS号1850-14-2 四甲氧基甲烷 | CAS号149-73-5 原甲酸三甲酯 | CAS号74-88-4 碘甲烷 | CAS号1445-45-0 原乙酸三甲酯 | CAS号17873-08-4 三甲基(苯硫甲基)硅烷 | CAS号104-95-0 4-溴硫代苯甲醚 | CAS号100693-33-2 [cyclohexen-1-y... | CAS号10575-06-1 but-3-ynylsulfa... | CAS号109607-24-1 2-chloro-1-(4-m... | CAS号3230-65-7 3,4-二氢异喹啉 | CAS号1193-82-4 苯亚砜甲酯 | CAS号3466-32-8 4-溴苯甲砜 | CAS号3446-89-7 甲硫基苯甲醛 | CAS号40027-88-1 1-(4-methylsulf... | CAS号456-56-4 苯基三氟甲基硫醚 | CAS号6852-58-0 N-二甲氨基苄叔丁胺

1,4-二氯苯置于bis(Triphenylphosphine)Nickel(II) Chloride体系中,用 苯 用作溶剂,化学反应 5.0H,反应生成茴香硫醚
参考文献:Selective Mono-Arylation And-Alkylation Of Chlorophenyl Alkyl Sulfides By Nickel Catalysed Cross-Coupling With Grignard Reagents
标题:Selective Mono-Arylation And-Alkylation Of Chlorophenyl Alkyl Sulfides By Nickel Catalysed Cross-Coupling With Grignard Reagents
摘要:
Doi:10.1016/s0040-4039(00)85672-5

专利信息

专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:US-2003125243-A1
优先权日:2000-07-20
标题:Synthesis of cyclic peptides
发明人：LIU JUN; DAI XUEDONG; SU ZHUANG
摘要:The cyclic pentapeptide cyclo(-Arg-Gly-Asp-D-Phe-Lys-) is a highly potent and selective inhibitor for the α v β 3 integrin. A related compound, cyclo(-Arg-Gly-Asp-D-Phe-Val-), is a promising anticancer drug candidate; it has been found to inhibit angiogenesis and induce apoptosis in vascular cells. We have developed a synthesis of arginine containing cyclic peptides using the cyclizcation reagent 1-propanephosphonic acid cyclic anhydride (T3P) and the guanidine protecting group, 2,2,5,7,8-pentamethylchroman-6-sulfonyl (Pbf). This improved synthesis is environmentally friendly and is generally applicable to the synthesis of other cyclic peptides.

专利号:US-7956011-B2
优先权日:2005-05-04
标题:Materials and methods for the photodirected synthesis of oligonucleotide arrays
发明人：SERAFINOWSKI PAWEL JERZY; GARLAND PETER BRYAN
权利人:CANCER RES INST ROYAL
摘要:Materials and methods for photodirected synthesis of oligonucleotide arrays on a solid substrate by photodirected synthesis are disclosed which employ a film formed from (i) a photoacid generator that on photolysis generates acid that is capable of directly removing the protecting group of the linker molecules or oligonucleotides and (ii) a polymer substantially lacking electronegative heteroatoms that are capable of hydrogen bonding with photogenerated acid. Methods of synthesizing an oligomer arrays are also described that use a film that restricts diffusion of reactants and products on the substrate during synthesis of the array and which includes a precursor of a deprotecting reagent. The method involves removing one or more of the non-required products of the deprotection reaction from the reactive array elements at which they are produced during the reaction, in order to displace the deprotection reaction towards completion.

专利号:US-2023242581-A1
优先权日:2020-06-17
标题:Synthesis of a guanylate cyclase agonist by fragments based approach
发明人：SAMBASIVAM GANESH; KASTURCHAND GODHA ATUL; VENKATA BHAGYARAJ ARETI; ANNADURAI SATHYA; VEERANJANEYULU AVULA; VASANTRAO GADAKH AMOL; S JADHAV DIPAK
权利人:ANTHEM BIOSCIENCES PRIVATE LTD
摘要:The present invention provides a process for the synthesis of Plecanatide, a guanylate cyclase agonist. The process involves convergent synthesis with compounds, i.e., fragment of peptides followed by cyclization. The method provides high yield of Plecanatide with less impurities.

专利号:WO-9817677-A1
优先权日:1996-10-24
标 题 :Improvements in solid-phase synthesis of peptides and related compounds
发明人：ENGLEBRETSEN DARREN
权利人:UNIV QUEENSLAND; ENGLEBRETSEN DARREN
摘要:The invention relates to spacers for use in solid-phase synthesis of peptides and peptide-related compounds, in which a spacer construct is used to ensure that the target peptide or peptide-related compound is at a distance equivalent to at least 5-15 amino acids from the solid support. Constructs of the invention are particularly applicable to the synthesis of strongly hydrophobic peptide, which are otherwise difficult, if not impossible to purify and analyse. The constructs and methods of the invention are also applicable to synthesis of peptide nucleic acids.

专利号:US-2012215002-A1
优先权日:2009-10-09
标 题:Synthesis of optically active intermediate for the preparation of montelukast
发明人：LEFORT LAURENT
权利人:LEFORT LAURENT
摘要:The present invention relates to the synthesis of optically active alcohols by means of enantioselective hydrogenation of ketones in biphasic systems. In particular the present invention relates to the synthesis of an optically active alcohol of general formula (1).