CAS: 1589-82-8; Benzylmagnesium Bromide

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CAS号100-39-0 溴化苄 | CAS号100-44-7 氯化苄 | CAS号7439-95-4 镁标准溶液 | CAS号10593-79-0 N-hydroxy-2-phe... | CAS号109021-78-5 dibenzyl(diethy... | CAS号31406-67-4 四苄基铪 | CAS号51135-96-7 4-苄基-4-羟基哌啶 | CAS号3290-53-7 (2-甲基烯丙基)苯 | CAS号36794-52-2 but-2-enedioic ... | CAS号613-42-3 4-苄基联苯 | CAS号350-92-5 1,1,1-三氟-3-苯乙酮 | CAS号451-40-1 二苯乙酮 | CAS号119-61-9 二苯甲酮

氯化苄置于盐酸,溴,Magnesium体系中,化学反应生成苄基溴化镁
参考文献:Stilbene-Based Materials,Their Preparation And Use
标题:Stilbene-Based Materials,Their Preparation And Use
摘要:式子i的物质:##str1## 其中r.Sub.1,R.Sub.2和r.Sub.3在每种情况下都可以相同或不同,并且是氢原子,卤素原子,羟基,硝基,氰基或一价,可选择取代的有机基团; R.Sub.4是氢原子,卤素原子,硝基,氰基或一价,可选择取代的有机基团; R.Sub.5可以相同或不同,是卤素原子,羟基,硝基,氰基或一价,可选择取代的有机基团.

专利信息

专利号:US-9982005-B2
优先权日:2013-04-04
标 题 :Macrolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

专利号:US-8933181-B2
优先权日:2006-10-06
标题:Branched polymers and methods for their synthesis and use
发明人：MOURI HIROSHI; LUO STEVEN; KURASCH JESSICA; ROBERTSON CHRISTOPHER G; WARREN SANDRA
权利人:MOURI HIROSHI; LUO STEVEN; KURASCH JESSICA; ROBERTSON CHRISTOPHER G; WARREN SANDRA; BRIDGESTONE CORP
摘要:Branched polymers including multi-branched polymers, functionalized branched polymers, star-branched polymers, and dendigraft polymers. Methods for the synthesis of branched polymers and method for the use of branched polymers in tire components are also included.

专利号:US-2006084825-A1
优先权日:2004-10-19
标题 :Novel method for the stereoselective synthesis of cyclic amino acids
发明人：BRYANS JUSTIN S; BLAKEMORE DAVID C; WILLIAMS SOPHIE C
权利人:WARNER LAMBERT CO
摘要:The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), inflammation especially arthritis, sleep disorders, premenstrual syndrome, and hot flashes. The invention provides novel routes to synthesize stereoselectively analogs of gabapentin (Neurontinâ„¢) of Formulas (I), (II), (III), and (IV) wherein R is C 1 -C 10 alkyl or C 3 -C 10 cycloalkyl and pharmaceutically acceptable salts thereof.

专利号:US-6340751-B1
优先权日:1998-07-24
标 题 :Process for the preparation of 4-substituted azetidinone derivatives
发明人：SAITO TAKAO; MURAYAMA TOSHIYUKI; MATSUMOTO TAKAJI; MIURA TAKASHI
权利人:TAKASAGO PERFUMERY CO LTD
摘要:Disclosed is a process for the preparation of a 4-substituted azetidinone derivative, which comprises reacting an azetidinone derivative and an amide compound in the presence of a magnesium compound such as those represented by the following formulas (II): n and (IV): n represented by the following formula (III): n n n MgR 5 R 6   (III) n n n wherein R 5 represents a C 1-12 alkyl group, a C 2-5 alkenyl group, a 5- to 8-membered alicyclic group which may be substituted by a lower C 1-4 alkyl group, a phenyl group which may be substituted by a lower C 1-4 alkyl group, a lower C 1-4 alkoxy group or a halogen atom or a benzyl group which may be substituted by a lower C 1-4 alkyl group, a lower C 1-4 alkoxy group or a halogen atom, and R 6 represents a halogen atom, a methanesulfonyloxy group, a benzenesulfonyloxy group, a p-toluenesulfonyloxy group, a trifluoromethanesulfonyloxy group, an acetoxy group which may be substituted by a halogen atom or a cyano group or an OR 7 group (R 7 representing a lower C 1-4 alkyl group, a substituted or unsubstituted phenyl group or a substituted or unsubstituted benzyl group). The process provides an industrially excellent process for the preparation of a 4-substituted azetidinone derivative which permits the selective preparation of an intermediate for the synthesis of a carbapenem antibacterial agent having a desired 1-β′ configuration.

专利号:EP-1237847-B1
优先权日:1999-12-08
标 题 :Method for the stereoselective synthesis of cyclic amino acids
发明人：BRYANS JUSTIN STEPHEN; BLAKEMORE DAVID CLIVE; WILLIAMS SOPHIE CAROLINE
权利人:WARNER LAMBERT CO
摘要:The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), inflammation especially arthritis, sleep disorders, premenstrual syndrome, and hot flashes. The invention provides novel routes to synthesize stereoselectively analogs of gabapentin (Neurontin®) of Formulas (I), (II), (III) and (IV) wherein R is C1-C10 alkyl or C3-C10 cycloalkyl and pharmaceutically acceptable salts thereof.

专利号:US-7067686-B1
优先权日:2005-07-21
标 题 :Synthesis of benzyl-metal compounds
发明人：RODRIGUEZ GEORGE; CANO DAVID ARTHUR; MCCONVILLE DAVID H; RIX FRANK C
权利人:UNIVATION TECH LLC
摘要:Disclosed are methods of producing di-, tri- or tetrabenzyl-metal compounds comprising combining a metal salt with a (benzyl) n MgX 2-n compound at from less than 30° C., wherein n is 1 or 2 and X is a monoanionic group; wherein the combining takes place in a diluent mixture comprising from 0 to 80% by volume of an ether diluent and a diluent selected from the group consisting of aromatic diluents, halogenated hydrocarbon diluents, and mixtures thereof. The methods are characterized by employing various mixtures of diluents, and in some cases, minimal to no ether diluent.