CAS: 205654-80-4; (2R,4S)-Benzyl 5-Oxo-2,4-Diphenyloxazolidine-3-Carboxylate
该化合物是一个化学化合物,其特点是氧化氮结构,由五人组成,含有氮和氧原子的环状体.这种化合物通常具有一种气质结构,如(2R,4S)的指定所示,它建议其替代成分的具体空间安排,能够影响其生物活动和反应.两种苯基组的存在有助于其芳香特性,有可能增强有机溶剂的稳定性和溶性.氧化氮碱盒式混合物表明,它可能参与各种化学反应,包括酯化和核分裂替代.这种化合物通常对药用化学感兴趣,因为它们作为药物合成的中间体或作为生物活性剂.
- 英文名称(2R,4S)-Benzyl 5-Oxo-2,4-Diphenyloxazolidine-3-Carboxylate
- 中文名称(2R,4S)-5-氧代-2,4-二苯基噁唑烷-3-羧酸苄酯
- IUPAC名称benzyl (2R,4S)-5-oxo-2,4-diphenyloxazolidine-3-carboxylate
- 其它别名Intermediate Of Rolapitant; (2R,4S)-Benzyl 5-Oxo-2,4-Diphenyloxazolidine-3-Carboxylate; 3-Oxazolidinecarboxylic Acid,5-Oxo-2,4-Diphenyl-,Phenylmethyl Ester,(2R,4S)-; 3-Fluoro-2-Nitrophenol (2R)-5-Oxopyrrolidine-2-Carboxylic Acid; Benzyl (2R,4S)-5-Oxo-2,4-Diphenyloxazolidine-3-Carboxylate
- CAS编号205654-80-4
- MFCD编号:MFCD30718663
- 分子式:C23H19NO4
- 分子量:373.41
- 产品CID: 1042584
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
相似化合物
143564-89-0 670254-71-4 205654-83-7物理性质
MSDS等安全信息
合成工艺路线路线简述
L-苯甘氨酸置于sodium Hydroxide体系中,用 二氯甲烷 用作溶剂,化学反应 72.08H,反应生成罗拉吡坦中间体
参考文献:New Methodology For The Synthesis Of A,A-Dialkylamino Acids Using The "Self-Regeneration Of Stereocenters" Method: A-Ethyl-A-Phenylglycine
标题:New Methodology For The Synthesis Of A,A-Dialkylamino Acids Using The "Self-Regeneration Of Stereocenters" Method: A-Ethyl-A-Phenylglycine
摘要:
Doi:10.3987/com-97-S83
海关参考信息
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专利信息
专利号:US-9260428-B2
优先权日:2007-03-22
标 题 :Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
发明人：MERGELSBERG INGRID; SCHERER DOMINIK HERMANN; HUTTENLOCH MONIKA ERIKA; TSUI HON-CHUNG; PALIWAL SUNIL; SHIH NENG-YANG
权利人:OPKO HEALTH INC
摘要:This application discloses a process to synthesize 8-({1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy)-methyl]-8-pheny-1.7-diaza-spiro[4.5]decan-2-one comprising reacting a compound of the Formula 27a-sulfonate with zinc in the presence of acetic acid.
专利号:US-9822116-B2
优先权日:2008-09-05
标 题:Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
发明人：WU GEORGE G; WERNE GERALD; FU XIAOYONG; ORR ROBERT K; CHEN FRANK XING; CUI JIAN; SPRAGUE VICTORIA M; ZHANG FUCHENG; XIE JI; ZENG LIANSHENG; CASTELLANOS LOUIS PETER; CHEN YUYIN; POIRIER MARC; MERGELSBERG INGRID
权利人:OPKO HEALTH INC
摘要:This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.
专利号:US-2014024834-A1
优先权日:2007-03-22
标题:Process and intermediates for the synthesis of 8-[-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
专利号:US-8552191-B2
优先权日:2007-03-22
标 题 :Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
专利号:US-2014031549-A1
优先权日:2008-09-05
标题:Process and Intermediates for the Synthesis of 8-[-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one Compounds
专利号:US-2016145256-A1
优先权日:2008-09-05
标题:Process and intermediates for the synthesis of 8-[-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
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主要参考文献
参考标题:Process And Intermediates For The Synthesis Of 8-[-Methyl]-8-Phenyl-1,7-Diaza-Spiro[4.5]Decan-2-One Compounds摘要:This Application Discloses A Novel Process To Synthesize 8-[1-(3,5-Bis-(Trifluoromethyl)Phenyl)-Ethoxy}-Methyl]-8-Phenyl-1,7-Diaza-Spiro[4.5]Decan-2-One Compounds, Which May Be Used, For Example, As Nk-1 Inhibitor Compounds In Pharmaceutical Preparations, Intermediates Useful In Said Process, And Processes For Preparing Said Intermediates; Also Disclosed Is A Process For Removal Of Metals From N-Heterocyclic Carbine Metal Complexes.
合成参考文献
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2016).
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